JPS61244366A - Drug component gradual release powder - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

Detailed Description of the Invention (Industrial Field of Application) The present invention relates to powder and granules that release medicinal ingredients in a sustained manner.By storing them in a container and opening the container, the medicinal ingredients to be released in a sustained manner can be released indoors. In addition to being used to maintain and improve health, sterilize, repel insects, and prevent mold, it can also be used as a mixture in paints applied indoors, as a mixture in adhesives used to manufacture interior materials, and as sheet materials. This paper proposes a material that is useful for improving the environmental conditions of indoor spaces and can be used in a wide variety of ways.

(Conventional technology) Terpenes emitted by forests can be used as aromatic substances for humans.
Phytoncides and forest bathing have been described in various books so far as being beneficial for improving the living environment, but in a recent book, ``Phytoncides and Forest Bathing'' (written by Mitsukatsu Yatagai, published by Tame Forestry Science and Technology Agency). Described in detail. Under these circumstances, products that are sprayed with terpenes, which are forest-derived ingredients, as indoor air fresheners or added to bath salts have become commercially available, but because they are in liquid form, they can be spilled indoors and contaminate the floor. There was a drawback.

Furthermore, even when mixed in liquid form with paints and adhesives for interior decoration materials for sustained release, it takes time and effort to ensure uniform adsorption to the base material, making it difficult to mix and use easily at home.
This was impossible for an amateur.

(Problems to be Solved by the Invention) Among terpenes, monoterpenes and sesquiterpenes evaporate relatively quickly, but as the molecular weight increases with diterpenes and tetraterpenes, evaporation generally becomes slower. One of the reasons why two types of embodiments are described in claims 1 and 2 in the present invention is that the evaporation rate is relatively slow, or the indoor space volume (volume) is large. When a high level of sustained release is required, the powder or granule according to claim 1 is suitable; in the opposite case, the powder or granule according to claim 2 is suitable. , the present invention can easily accommodate various conditions.

Conventional liquid fragrances made of so-called forest-derived ingredients have not solved this problem.

(Means for Solving the Problems) In the present invention, as a method for improving the drawbacks of conventional products, organic or inorganic powders with high oil absorption, such as organic powders such as wood flour and pulp powder, anhydrous Silicic acid,...
This is done by impregnating and adhering terpene-based substances to inorganic powders such as . In addition, in the case of pinene, which evaporates faster in the atmosphere than 1.8 cineole or borneol, as shown in claim 2, the surface of the terpene-based substance-containing powder or granules is It is appropriate to surround it with an organic or inorganic thin film.

(Example 1) A terpene-based product with a total of 40% by weight of ne1.8 cineole and 1.4 cineole, and the shallow part consists of several types of monoterpenes! (Manufactured by Yasushi Oil Industries Co., Ltd., product name: Cineol D)
was gradually added to the finely divided silicic anhydride that was being stirred, and the stirring was stopped when the same weight of the terpene-based substance as the weight of the powder was adsorbed. The obtained powder was in the form of a fine powder that did not give the impression of oil even though it had an oil content of 50%), and it emitted a terpene aroma.

This powder was added and mixed in an amount of 10% by weight to a household fiber wall material kneaded with water, and was applied to about 1.5 tsubo of a 1-tatami surface of a 4.5-tatami room. After drying, the air concentration in the room was measured and found to be 5 ppb, and even after a year, the concentration was still 1.81 ppb.
) pb was detected, and it was found that sustained release was carried out over a long period of time.

Incidentally, when only Cineol D was added to the mixture of household fiber wall materials and water, the oil separated and floated to the surface and could not be mixed uniformly.

(Example 2) Dry crushed grains of cedar wood were immersed in limonene (manufactured by Yasushi Oil Industries Co., Ltd., trade name: D-limonene), roasted, and kept at room temperature until a slight oil content was felt on the grain surface. When dried, the oil content was 25% by weight.The surface of this oil content was coated with a polyvinyl alcohol aqueous solution spray to give a smooth or granular oil content.

When we put 50 y of this oil in a cupboard and tested the growth of mold by throwing soybean flour on an agar medium, we found that mold growth was delayed by 10 days compared to an agar medium in a normal cupboard, indicating that it has a mold-preventing effect. understood. Among them, this effect lasted for 8 months at an oil content of 50P.

"Effect" As described above, the medicinal ingredient sustained release powder of the present invention contains natural essential oils that are extracted from plants.
In addition to being beneficial to the human body, it is easy to handle and can be applied in a variety of fields.

Claims (2)

[Claims] (1) A granular material for sustained release of medicinal ingredients, which is characterized by containing a terpene-based substance in a highly oil-absorbing organic or inorganic granular material. (2) A powder or granule material containing a terpene-based substance as set forth in claim 1, the surface of which is surrounded by an organic or inorganic thin film, which releases a medicinal ingredient in a sustained manner.