JPS61228868A - Resin used in medial pressure-sensitive agent and medical pressure-sensitive sheet or tape using the same - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

Detailed Description of the Invention (Industrial Application Field) The present invention relates to an acrylic resin used in a bactericidal (antibacterial) medical adhesive, and a medical adhesive sheet using an adhesive containing the resin. Or about the tape.

(Prior Art) Adhesives for medical adhesive sheets or tapes, such as patches and adhesive plasters containing drugs, have good adhesion to the skin and excellent aging resistance.

Traditionally, acrylic adhesives have been most commonly used because they have excellent properties such as not altering the quality of the drugs they contain and not irritating the skin.

For example, Japanese Patent Publication No. 52-31405 discloses a patch in which a water vapor-impermeable film is provided with an adhesive layer containing a steroid hormone, and the adhesive is an alkyl acrylate. It is a copolymer of ester and acrylic acid. JP-A-57-77167 discloses a patch containing nitroglycerin as a drug for treating angina pectoris.

The adhesive is a copolymer of methacrylic acid dodecyl ester, (meth)acrylic acid and vinyl acetate. Furthermore, Japanese Patent Application Laid-Open No. 56-45412 discloses a drug-containing patch using an adhesive with high drug solubility. The adhesive is a (meth)acrylic acid ester with 9 ether bonds in its molecules.

It is a copolymer of acrylic acid and (meth)acrylic acid alkyl ester.

As described above, medical sheets or tapes using acrylic adhesives have various excellent features such as good adhesion to the skin surface. However, the above-mentioned conventional acrylic pressure-sensitive adhesives inherently lack hydrophilicity. In other words, since the adhesive has poor moisture absorption ability and poor breathability, stuffiness occurs when the sheet or tape is applied to the skin for a long time.

As a result, the skin becomes easily sensitized to even the slightest irritation caused by drugs or the like, causing a rash.

Bacteria, fungi, and other germs can grow abnormally in the stuffy patch area, which can easily cause a rash due to secondary sensitization.

To suppress rash caused by stuffiness, for example, Tokko Sho 3
Publication No. 9-4728 discloses a medical pressure-sensitive adhesive sheet in which a pressure-sensitive adhesive containing an acrylic acid alkyl ester, acrylic acid, etc. as a copolymerized component is provided in a layered form having open cells on a porous fibrous base material. There is. Such adhesive sheets are highly breathable and do not cause stuffiness. However, since the base material and the adhesive layer are permeable to liquids such as water, it is not possible to sufficiently protect affected areas such as wounds. Tokuko Sho 55-141
No. 08 discloses an adhesive layer made of polyvinylethyl ether having hydrophilic groups in two molecules or an acrylate copolymer having hydrophilic groups in the molecules on a film with high water vapor permeability (for example, a polyurethane film). A medical adhesive sheet is disclosed. Such a pressure-sensitive adhesive sheet has relatively good air permeability and the base material is hardly permeable to liquids such as water, so it provides relatively good wound protection. However, since the adhesive itself does not have bactericidal properties, it cannot prevent infection of the wound or secondary infection rash caused by microorganisms that have grown in the adhesive layer.

Sheets or tapes using such adhesives include:
There are also primary disadvantages due to the fact that acrylic pressure-sensitive adhesives are inherently poor in hydrophilicity or are insoluble in water.

■It is difficult to apply the sheet or tape to a wet or damp surface, for example.

Poor adhesion to sweating skin surfaces. If you continue to sweat a lot after applying it, remove it.

■Adhesive that protrudes from around the patch sheet or tape, and adhesive that remains on the skin surface after peeling off the sheet or tape, cannot be washed away with water.

(2) For example, water-soluble drugs in the form of sodium salts, potassium salts, ammonium salts, hydrochloride salts, etc.9 usually dissolve only in water or alcohol.

Therefore, it is difficult to dissolve such a drug in an adhesive, and therefore it is difficult to prepare an adhesive sheet or tape containing it.

(Problems to be Solved by the Invention) The present invention solves the above-mentioned conventional drawbacks, and its purpose is to provide an acrylic adhesive that can form a medical adhesive with bactericidal (antibacterial) properties. The objective is to provide a series of resins. Another object of the invention is.

The object of the present invention is to provide a medical adhesive sheet or tape that has an adhesive layer using the above resin and does not cause secondary sensitization rash due to microbial infection or microbial proliferation. Another object of the present invention is to provide an acrylic resin that can form a hydrophilic medical adhesive. Still another object of the present invention is to provide a pressure-sensitive adhesive layer using the above-mentioned hydrophilic resin on a base material.

The object of the present invention is to provide a medical adhesive sheet or tape having the following excellent properties.

■Can be attached to wet (moist) skin surfaces.

A sheet or tape that does not peel off easily even if you sweat during application.

■A sheet or tape that can be easily removed by washing with water even if the adhesive protrudes around the sheet or tape when it is applied or remains on the skin surface after peeling off.

■Water-soluble drugs that could not be dissolved and contained in acrylic adhesives 1 For example, drugs in the form of salts such as sodium salts, potassium salts, ammonium salts, and hydrochlorides can be dissolved and contained in high concentrations. A sheet or tape with a sticky adhesive.

(2) A sheet or tape that does not smell during application because the adhesive has water absorption ability and/or water vapor permeability, and therefore does not cause rashes caused by this stuffiness.

Still another object of the present invention is, in addition to the above-mentioned valuable properties, to
The object of the present invention is to provide a pressure-sensitive adhesive resin having the inherent advantages of an acrylic pressure-sensitive adhesive, and a medical pressure-sensitive adhesive sheet or tape using the same and having a pressure-sensitive adhesive layer on its surface.

(Means for Solving the Problems) The resin used in the medical adhesive of the present invention is a resin made of a copolymer containing a first copolymer component and a second copolymer component, ) the first copolymerization component.

(a) A saturated hydrocarbon group having a quaternary ammonium salt (
(meth)acrylamide derivative substituted with one of the active hydrogen atoms of meth)acrylamide, and/or
A saturated hydrocarbon group with a quaternary ammonium salt (meta)
It is a (meth)acrylic acid ester derivative substituted with an active hydrogen atom of acrylic acid; and (2) the second copolymerization component is vinylpyrrolidone and/or diacetone acrylamide.

This achieves the above objective. moreover.

The medical adhesive sheet or tape of the present invention is a medical adhesive sheet or tape in which an adhesive layer is provided on at least one side of a base material, and the adhesive is composed of a first copolymer component and a second copolymer component. (1) the first copolymerization component is 1a) a saturated hydrocarbon group having a quaternary ammonium salt substituted with one active hydrogen atom of (meth)acrylamide; (meth)acrylamide derivative.

and/or (b) a (meth)acrylic acid ester derivative in which a saturated hydrocarbon group having a quaternary ammonium salt is substituted with an active hydrogen atom of (meth)acrylic acid; and (2) the second copolymerization component is vinylpyrrolidone and/or
or diacetone acrylamide, thereby achieving the above object.

The resin used in the medical adhesive of the present invention is a (meth)acrylamide derivative (1) having the following structural formula and/or
Or it is a copolymer containing (meth)acrylic acid ester derivative (II) as the first copolymerization component: (Hereinafter, blank space)
(wherein, Ra is H or C8; R is Carbon number 1
~6 saturated hydrocarbon group or a saturated hydrocarbon group having 1 to 6 carbon atoms having a hydroxyl group; RI+R9 and Lo are alkyl groups having 1 to 3 carbon atoms; and X is a halogen atom such as CI or Br).

Among the compounds represented by the above structural formula, (meth)acrylamide derivatives (I) include 3 (acrylamido)propyltrimethylammonium chloride, 3 (
Examples include methacrylamide)propyltrimethylammonium chloride, 3(acrylamido)isopentyltrimethylammonium chloride, and 3(methacrylamido)propyldimethylethylammonium chloride. As the (meth)acrylic acid ester derivative (II).

2 (methacryloxy)ethyltrimethylammonium chloride 23 (methacryloxy)2hydroxypropyltrimethylammonium chloride, 2 (acryloxy)ethyldiethylmethylammonium chloride, 3 (acryloxy)propyltrimethylammonium chloride, and the like.

In addition to the first copolymer component, vinylpyrrolidone and/or diacetone acrylamide are contained as a second copolymer component. Furthermore, in addition to the above-mentioned first and second copolymer components, a third copolymer component may be contained as necessary. The third copolymerization component has an alkyl group having 1 to 12 carbon atoms.
A (meth)acrylic acid alkyl ester and/or a fatty acid vinyl ester whose fatty acid has 1 to 4 carbon atoms are used. Among these, the (meth)acrylic acid alkyl ester is ethyl acrylate.

Butyl acrylate, isobutyl acrylate, 2-ethylhexyl acrylate, octyl acrylate.

These include lauroyl acrylate, methyl methacrylate, butyl methacrylate, and 2-ethylhexyl methacrylate. Examples of fatty acid vinyl esters include vinyl acetate, propionic acid, and vinyl.

The copolymer contains the first copolymer component in an amount of 5 to 70% by weight, and the second copolymer component in an amount of 30% or more by weight of the remaining components of the first copolymer component. When the third copolymerization component is contained, the third copolymerization component is contained in a proportion of 50% by weight or more of the remaining components of the first and second copolymerization components.

1st. Two or more types of the second and third copolymer components may be mixed.

The degree of bactericidal properties of an adhesive prepared using a copolymer resin increases in proportion to the proportion of the first copolymer component in the copolymer. Therefore, if the first copolymer component is too small, sterilizing or antibacterial properties cannot be obtained. The first copolymer component is preferably contained in a proportion of 30% by weight or more. The degree of sterilization also depends on the chemical structure of the first copolymer component, the influence of other copolymer components on the first copolymer component, the amount of plasticizer described below, and the like.

What is the degree of water solubility or hydrophilicity of the copolymer resin?

Depending on the content of the first copolymer component and/or the second copolymer component, the greater the proportion of these components in the copolymer, the greater the water solubility. If the water solubility of the copolymer resin consisting only of the first and second copolymer components is too high, for example, it is possible to add a third copolymer component to reduce the degree of water solubility of the copolymer. It is. When the amount of the first and second copolymer components is decreased and the amount of the third copolymer component is increased.

The copolymer has reduced water solubility and becomes hydrophilic (indicating water swelling or water absorbing properties).

For example, when the first copolymer component is 5% by weight and the second copolymer component is increased, the properties of the copolymer change from hydrophilic to water-soluble. When it is.

The total amount of the first and second copolymer components in the copolymer is approximately 70% by weight (at this time, the total amount of the third copolymer component and, if necessary, other components described below) is approximately 3% by weight.
0% by weight). When the first copolymerization component is a (meth)acrylic acid ester derivative, the first and second copolymerization components
The total amount of copolymer components accounts for approximately 80% of the copolymer.
Weight%.

When the first copolymerization component is 15% by weight, when the first copolymerization component is a (meth)acrylamide derivative, approximately 50%
When the first copolymerization component is a (meth)acrylic acid ester derivative, it is about 70% by weight. On the other hand, the second
The amount of copolymerization components is kept to a minimum.

The reason why the copolymer changes from hydrophilic to water-soluble when the amount of the first copolymer component is increased is that the first copolymer component is (meth)
When it is an acrylamide derivative, the content of the first copolymer component is approximately 20% (in this case, the content of the second copolymer component is approximately 25%).
). When the first copolymer component is a (meth)acrylic acid ester derivative, the content of the first copolymer component is about 30% (in this case, the content of the second copolymer component is about 20%).

The degree of water solubility of the copolymer is determined by the above 1. 2nd and 3rd
It depends not only on the content ratio of the copolymerized components, but also on the type of each component and the amount of the fine crosslinking agent (polyfunctional monomer) used, which will be described later. For example, when a (meth)acrylamide derivative is used as the first copolymerization component, the degree of water solubility (hydrophilicity) of the resulting copolymer is greater than when a (meth)acrylic acid ester derivative is used. Among the (meth)acrylamide derivatives and (meth)acrylic acid ester derivatives, the one with fewer total carbon atoms constituting nine molecules has a higher degree of water solubility (hydrophilicity). The smaller the total number of carbon atoms constituting the third copolymer component (for example,
In the case of acrylic acid alkyl esters, the lower the number of carbon atoms in the alkyl group, the higher the degree of water solubility (hydrophilicity).

When copolymerization is carried out by adding a small amount of a polyfunctional monomer in addition to the above-mentioned copolymerization components, the internal cohesive force of the resulting copolymer can be improved. As the polyfunctional monomer, a monomer in which two or more (meth)acrylate groups are substituted at the terminals of the nine molecules is preferably used.

For example, alkylene glycol di(meth)acrylates such as 1,6-hexane glycol (meth)acrylate; polyalkylene glycol di(meth)acrylates such as polyethylene glycol di(meth)acrylate;
Acrylate; trimethylolpropane tri(meth)
Poly(meth)acrylates of polyhydric alcohols such as acrylates are preferably used. When a polyfunctional monomer is contained, crosslinking (slight crosslinking) occurs, albeit very slightly, during copolymerization, thereby increasing the internal cohesive force of the copolymer.

Therefore, when a sheet or tape using the obtained adhesive is applied, the adhesive does not protrude to the surrounding area, and when the sheet or tape is peeled off, a part of the adhesive does not remain on the skin surface. The greater the amount of polyfunctional monomer added during polymerization, the greater the degree of micro-crosslinking of the copolymer.

Slight crosslinking creates a network structure and reduces the water solubility of the copolymer. Therefore, it is also possible to reduce the water solubility of the adhesive to an appropriate level by adjusting the degree of slight crosslinking. Even if slight crosslinking is performed, the copolymer resin does not precipitate out of the solution and remains stable for a long period of time at a normal coating concentration (approximately 20
% or more) remains in solution.

The polyfunctional monomer is added at a rate of 0.001 to 0.02% by weight of the total copolymerization components (total monomers) during polymerization.

If it is in excess, the resulting copolymer will have poor solubility in solvents such as alcohol and water. It is preferable to add the polyfunctional monomer at the initial stage of polymerization in order to effectively form a slight crosslink.

Other polymerizable monomers may be copolymerized to the extent that they do not impair the characteristics of the copolymer resin of the present invention, such as bactericidal properties.Such polymerizable monomers include 9, for example: Acrylic acid, methacrylic acid, (meth)acrylic acid 2-hydroxyethyl ester, (meth)acrylic acid 2-hydroxypropyl ester, dimethylacrylamide, dimethylaminopropyl (meth)acrylamide, n-butoxymethylacrylamide, dimethylaminoethyl acrylate ester, ethoxyethyl acrylate, tetrahydrofurfuryl acrylate, and glycidyl methacrylate.

These other polymerizable monomers have a content □ of the first
5 of the remaining components of the copolymerization component and the second copolymerization component
Copolymerized to less than 0% by weight. Of the above,
When water-soluble monomers such as acrylic acid 2-hydroxyethyl ester are used, copolymers with a high degree of hydrophilicity are obtained. Therefore, when using such a monomer, the amount of each component is adjusted with regard to hydrophilicity, considering the same as if the amount of the second copolymer component had increased.

The above-mentioned first copolymerization component and second copolymerization component, and if necessary, a third copolymerization component (all monomers), a polyfunctional monomer, and other polymerizable monomers are subjected to normal radical polymerization. Method 1 For example, a copolymer is obtained by subjecting it to a polymerization reaction using a solution polymerization method. To obtain a copolymer by solution polymerization method 1 For example, charge each of the above monomers into a reactor equipped with a reflux condenser.

The solution is 60-90% by weight. The optimal solvent is selected from water, methanol, ethanol, isopropyl alcohol, etc. Usually methanol.

Ethanol and the like are preferably used. A catalyst is added to this, and the reaction is carried out under an inert gas atmosphere while heating and stirring. The catalyst needs to be soluble in the solvent system during the double polymerization, and from the viewpoint of this solvent system, an azobis-based catalyst is particularly preferably used.

The amount of catalyst is usually in the range of 0.1 to 0.5 mol % based on the number of moles of all monomers. The catalyst is dissolved in about 175 or less volumes of solvent, usually 10 to 10.
It is divided into 5 portions and added to the reaction solution. The interval at which the catalyst is added is determined from the half-life of the catalyst at one reaction temperature (for example, 60° C.). For example, in the first half of the polymerization reaction, the catalyst is preferably added at intervals of 173 to 1 times its half-life. The reaction temperature is usually 50 to 80°C. For example, the first half of one polymerization reaction, about 24 hours, is carried out under relatively mild conditions at around 60°C, and the second half, about 20 hours, is carried out at 70 to 80°C.
A method in which the reaction is carried out under temperature conditions of around 0.degree. C. is preferably used.

(Left space below) No apparent change occurs for about 30 minutes to 1 hour after the catalyst is first introduced, but when the first polymerization reaction starts thereafter, the viscosity of the reaction liquid increases and the first reaction temperature also rises. Since the polymerization rate is high for several hours after the start of polymerization, runaway reactions and gelation will occur if left standing. Therefore, it is necessary to add a solvent to the first reaction system to lower the viscosity or to control the second reaction temperature. especially.

Controlling the reaction by diluting the solvent is important. When the viscosity of the solution increases, 5 to 10% of the solvent is added based on the total amount of the reaction solution. By adding the solvent several times to more than 10 times in this way, the apparent viscosity of the reaction solution can be increased to 10,000 to 20,000
Try to keep it at 0OOcps. When the polymerization reaction is carried out in a reaction system containing a moderate amount of the third copolymerization component as a copolymerization component, even if the viscosity increases, it is possible to easily reduce this and proceed the reaction smoothly. . Even after no increase in the viscosity of the reaction solution is observed, the catalyst is continuously added until the specified amount is reached. The polymerization reaction starts from the beginning of polymerization.
It is preferable to carry out the reaction for 0 hours or more in order to increase the polymerization rate.

The amount of monomers in the reaction solution can be determined by liquid chromatography for the first copolymerization component and diacetone acrylamide among the second copolymerization components.

Vinylpyrrolidone of the second copolymerization component, and the third
Copolymerized components can be quantitatively determined using gas chromatography. The zero polymerization rate, which can be determined by measuring the amount of monomer remaining in the reaction solution in this way, is usually 97% or more. The resulting reaction solution is a colorless to milky white solution with a polymer concentration of 30-40% by weight and a viscosity of 20.000-40% at 21°C.
000cps.

Although the copolymer thus obtained may exhibit tack as it is, 9 it is usually non-adhesive and is relatively brittle and hard in the form of a resin in the dry state. However, when a suitable plasticizer is added to it, the copolymer becomes soft and sticky. The internal cohesive force is also moderate, and it comes to have viscoelastic properties. Water can also be used as plasticizer. However, since constant viscosity cannot be obtained due to water evaporation, 2 a water-soluble or hydrophilic liquid with a high boiling point is usually used. Water-soluble liquids and solids with large water retention properties are also used. Water may be added to these plasticizers as necessary. For plasticizers.

For example, glycerin, jigglycerin. Propylene glycol, trimethylene glycol, α-butylene glycol, 2,3-butylene glycol.

β-butylene glycol, α-amylene gelicol, 2
-3-amylene gelicol, 2,4-amylene gelicol, 1,4-amylene gelicol.

Cationic surfactants such as 1,5-bentanediol, trimethylolethane, polyethylene glycol, polypropylene glycol, starch sugar, sucrose, sorbitol urea, long chain alkyl trimethyl ammonium chloride, polyoxyethyl alkyl ethers or esters, fatty acid jetanolamide , nonionic surfactants such as sorbitan alkyl esters, amphoteric surfactants such as dimethylalkyl betaine, and liquid amino acids.

Two or more plasticizers may be used in combination.

When the plasticizer is a liquid, the plasticizer enters between the molecules of the copolymer resin and acts on the portions corresponding to the first copolymer component and the second copolymer component, thereby changing the molecules of the two copolymer molecules. Activate exercise and soften. Water works with plasticizers,
This may be softened in some cases. In that case, because the water retention capacity of the plasticizer is large.

Water exists relatively stably in the copolymer. Since evaporation of water is suppressed, the adhesive properties do not change.

The amount of plasticizer depends on the composition of the copolymer components and the type of plasticizer.

Although it varies depending on the thickness of the adhesive layer and the desired degree of tackiness, it is usually 0 to 100 parts per 100 parts by weight of the copolymer.
Parts by weight (0-100.phr), preferably 30-7
It is in the range of 0 phr. In other words, the amount of copolymer in the adhesive is 50~. 100% by weight and plasticizers in a proportion of 50-0% by weight.

The larger the content ratio of the first and second copolymer components, the greater the amount of plasticizer required. This is the first step in the copolymer resin.
The higher the proportion of the second copolymer component, the less adhesive it becomes and the resin-like appearance; This is because it comes to have a certain characteristic.

For example, the first copolymer component is 30% by weight in the copolymer, and the second copolymer component is 50% by weight in the remaining components.
When adding diglycerin as a plasticizer to obtain a medical bandage with an adhesive layer thickness of 50 μm, it is appropriate to set the amount of plasticizer to 50 phr. When water is added to the plasticizer, approximately the same tackiness can be obtained by reducing the amount of plasticizer by the same amount as the water added. When the amount of the first copolymer component in the copolymer increases, the amount of the first copolymer component increases by about 1.5 compared to the case where the second copolymer component increases
A double increase in the amount of plasticizer is required to develop equivalent tack. The amount of plasticizer is preferably determined by testing on a case-by-case basis.

The degree of water solubility of the adhesive obtained by adding a plasticizer to the copolymer resin as necessary is determined as described above.

It is mainly determined by the copolymer composition, but is also influenced by the type and amount of plasticizer used.

For example, the more a highly hydrophilic plasticizer such as 8-glycerin is blended, the greater the degree of water solubility and the faster the rate of dissolution in water.The greater the water absorption.

The adhesive prepared using the copolymer resin thus obtained has bactericidal (antibacterial) properties, and also has appropriate hydrophilicity, water absorption, moisture permeability, and electrical conductivity. The reason why such a copolymer resin exhibits the above-mentioned excellent properties is considered to be mainly due to the first copolymer component. However, even if a polymer in which only the (meth)acrylamide derivative or (meth)acrylic acid ester derivative, which is the first copolymerization component, is homopolymerized, an adhesive with sufficient viscoelasticity cannot be obtained. The same applies to homopolymers of vinylpyrrolidone and diacetone acrylamide, which are polymerization components. The homopolymer of the third copolymer component has very poor hydrophilicity. In the copolymer resin of the present invention, the first and second copolymer components and, if necessary, the third copolymer component are copolymerized to form a uniform composition, and each copolymer component is different from the first copolymer component. It is thought that they are copolymerized to help the functions of the copolymerized components. It is believed that the addition of a plasticizer softens the entire resin, further enhancing these properties.

As a similar compound of the first copolymer component, it has been known that a low molecular weight compound having a quaternary ammonium salt has bactericidal properties. This low-molecular-weight compound comes into contact with microbial cells and is adsorbed onto their surfaces.

Furthermore, it is believed that the quaternary ammonium salt portion of the salt penetrates into cells and exhibits bactericidal activity. However, one reason is that the copolymer resin of the present invention is a polymer.

Such a bactericidal mechanism cannot explain its bactericidal action. It is thought that when the copolymer resin is plasticized and in a softened state, microorganisms are adsorbed to the quaternary ammonium salt portion, and a bactericidal effect is exerted.

A layer of the above adhesive is formed on at least one side of the base material to obtain a desired medical adhesive sheet or tape. Examples of base materials include polyurethane, polyurethane-polyamino acid cocondensate, polyethylene, ethylene-vinyl acetate copolymer, ethylene-acrylic acid ester copolymer, and polyvinyl chloride.

Unplasticized soft polyvinyl chloride (internal copolymer or blend system), polypropylene, nylon, polyester, soluble polyvinyl alcohol, insolubilized polyvinyl alcohol, insolubilized polyvinyl acetal, recycled cellulose, cellulose esters.

Cellulose esters, silicone rubber, foamed polyethylene, foamed polyurethane, foamed ethylene-vinyl acetate copolymer, etc. are used in the form of a film or sheet. In addition, paper, nonwoven fabric, woven fabric, &1 cloth made of natural fibers or synthetic fibers may also be used, and 2 breathable or non-breathable base materials are selected as appropriate depending on the purpose. . It is also possible to use the above film, cloth, etc. in combination as a laminate or a laminate.

When obtaining a sheet or tape intended for drug treatment, the drug is blended into the adhesive.

Drugs include anti-inflammatory agents, anti-inflammatory analgesics, antihistamines, anti-allergic agents, bactericidal and antibacterial agents, antifungal agents, antihypertensive agents, coronary vasodilators, sedatives, and stimulants.

Anti-motion sickness drugs, anesthetics, etc.

A method for forming a layer of an adhesive or an adhesive containing a drug on a substrate can be performed by any known method.

For example, applying a solution containing an adhesive directly to the surface of the base material.
Direct coating method that dries; once the adhesive solution is applied.

A direct transfer method is used in which the adhesive is applied onto a flat endless belt having a releasable surface, dried, and then a base material is pressed onto this surface and peeled off to transfer the adhesive onto the surface of the base material. In addition, an indirect transfer method may also be suitably used in which a pressure-sensitive adhesive solution is once coated on a release paper, dried, and then a base material is pressed onto the coated surface.

(Function) The adhesive obtained using the copolymer resin of the present invention has excellent adhesiveness, is less irritating to the skin, and does not alter the quality of the drug.
It has the characteristics of conventional acrylic adhesives, such as, and has excellent bactericidal (antibacterial) properties. Medical sheets or tapes provided with such adhesive layers can be used in a wide variety of applications. For example, it is applied directly or indirectly through gauze to protect a wound. The bactericidal action of the adhesive prevents infection due to bacterial infiltration, thus speeding up the healing of wounds.

Even if stuffiness occurs when applying the sheet or tape.

Microorganisms will not propagate in that area and cause a rash due to secondary sensitization. It is also possible to affix such a sheet to the surgical site in advance and perform the surgery over it. When used as a drape in this way, it is possible to eliminate excessive disinfection before surgery and to prevent infection due to various bacteria entering the incision site during surgery.

The adhesive also has excellent hydrophilic properties. The ability to absorb moisture allows the sheet or tape to adhere to wet (moist) skin surfaces. Even if you sweat during application, the adhesive has a high moisture absorption capacity, so it will not soften due to absorption of moisture and cause the sheet or tape to peel, or the adhesive will become fluid and will not cause the so-called adhesive residue phenomenon. It does not soften or harden due to the influence of humidity during storage. It also has excellent water vapor permeability.

Even if the sheet or tape is applied to the skin for a long time, rash due to stuffiness is hardly observed. If the base material itself is permeable to water vapor, no N leakage will occur, or when the sheet or tape is applied.

For example, the adhesive may spill out due to body movements, or #
Even if the adhesive remains on the skin after removal, it can be easily washed and removed with water. Furthermore, water-soluble drugs 2, such as drugs in the form of salts such as alkali metal salts, ammonium salts, and hydrochlorides, can be dissolved in the adhesive at a high concentration. Therefore, a medical adhesive sheet or tape containing a water-soluble drug, which has been difficult to prepare in the past, can be easily obtained.

Furthermore, since the adhesive has conductivity, it has a large antistatic effect. For example, when a conventional roll-shaped adhesive tape made of a highly electrically insulating base material such as polyethylene or polypropylene is unwound, the tape may be charged with static electricity of several thousand to several thousand volts.

Therefore, the adhesive may adhere to other objects or cause spark discharge before it is attached to the object. 1 when spark discharge occurs
For example, in operating rooms where anesthetic ether is used, there is also a risk of ignition. On the other hand, if the sheet or tape of the present invention is used.

There is no such danger because the adhesive has no electrostatic properties.

When a polyfunctional monomer is added during copolymer preparation, a pressure-sensitive adhesive with even better internal cohesive strength can be obtained due to slight crosslinking. Sheets or tapes using such adhesives do not suffer from the phenomenon of so-called adhesive cracking or adhesive residue, regardless of the adhesive film thickness.

(Example) The invention will now be explained with reference to examples.

(A) Preparation of copolymer: 70 g of 3(methacrylamido)propyltrimethylammonium chloride as the (meth)acrylamide derivative (first copolymerization component), second
60 g of N-vinyl-2-pyrrolidone as a copolymerization component,
30 g of butyl acrylate as the third copolymerization component, and 0.015 g of 1,6-hexane gelicol dimethacrylate as the polyfunctional monomer.

Then, 70g of methyl alcohol was added as a solvent to the reaction vessel (
1N) and heated to 60° C. with stirring under a N2 stream. Azobisisobutyronitrile 0 as a polymerization catalyst
．． 4g was used. The catalyst was dissolved in 100 mf of ethyl acetate, and 5 ml of the catalyst was added to the reaction system every 3 hours.

After 4 injections (after 12 hours), an additional 10 nl was added every 4 hours. 24 hours after the start of the reaction, the reaction temperature was set to 70°C, and 10++j! of catalyst solution was added every 3 hours. Added one by one. during the polymerization reaction.

Especially at the beginning of polymerization (2 to 10 hours after adding the catalyst solution).

If the viscosity of the reaction solution increased significantly, stirring would become difficult and gelation or runaway reaction might occur, so ethyl alcohol was added 10 times at 20 to 30 ajt each. After no increase in viscosity was observed, only heating and stirring were continued. In this way, the apparent viscosity of reaction solution 9 was maintained at 15.0 OOcps (centivoids) or less. After the addition of the catalyst solution was completed, stirring was continued for 8 hours at the same temperature (70° C.), and the reaction was completed 44 hours after the start of double polymerization. The resulting reaction solution was transparent and slightly yellow, the concentration of the copolymer contained was 34.4%, and the viscosity was 2.2% at 21°C.
It was 9.0OOcps. When the polymerization rate was calculated from the residual monomer rate, the overall copolymer was 98.7%.
The first copolymer component is 99.8%, and the second copolymer component is 97%.
3%, and the third copolymerization component was 98.8%. When this reaction solution was diluted by adding a non-aqueous solvent such as toluene or ethyl acetate, the polymer components coagulated to form a precipitate. However, by adding water or alcohol to the two reaction solutions, it was possible to dilute it to an arbitrary concentration.

(B) Preparation of adhesive sheet: The polymer obtained from the copolymer solution obtained in section (A) was a hard, slightly brittle, non-adhesive resinous material. Diglycerin was added as a plasticizer to the copolymer solution obtained there. Polymer component 1
Appropriate tackiness was obtained when 35 to 5 parts by weight of Jigguse 9F was added to 00g. An adhesive solution was obtained by adding 50 parts by weight of diglycerin to 100 g of the polymer component of the copolymer solution obtained in section (A). This was coated and dried on the surface of the base material so that the thickness after drying was 50 μm. 9 A stretched crosslinked polyvinyl alcohol film with a thickness of 50 μm was used as the base material.

(C) Adhesive substitute physical properties of adhesive: Adhesive substitute physical properties were investigated using the adhesive sheet obtained in section (B).

(1) 180@folded paper adhesion force and (2) ball tack value were measured by the following methods. (3) A test was also conducted for cohesive failure. The adhesive strength of the 180'' folded paper was 790 g/15 mm width, the ball tack value was 26, and no cohesive failure was observed.

(11180@Folding Method Adhesive Crab The adhesive sheet obtained in section (B) was cut into 15 mm width to obtain adhesive tape. This adhesive tape was attached to the surface of a stainless steel plate polished with sandpaper (#280). The pressure bonding was performed using a 2 kg rubber-covered roller by making one reciprocation at a speed of 300 mm/min. After the pressure bonding, the roller was left at room temperature (20-22°C) for 30 minutes or more, and then one end was folded back 180' and the pressure was applied at a speed of 300 mm/min. Forced peeling was performed at a constant speed, and the adhesive force at this time was measured (J
IS-Z-1522).

(2) Ball tack value: The adhesive sheet obtained in section (B) was cut into a width of 30** or more to obtain an adhesive tape.

This adhesive tape was fixed to a 30" inclined surface at room temperature with the adhesive side facing outward.A portion of the adhesive surface approximately halfway down from the top of the slope was covered with a non-adhesive thin film.From that boundary line A cleanly wiped ball bearing ball was allowed to roll naturally on a slope from a distance of 100 m.The maximum normal diameter (1/ It is expressed in units of 32 inches and is indicated by the number of its numerator; for example, 17/32 inch is 17)
was taken as the ball tack value (Pharmaceutical Manufacturing Guidelines (1984))
).

(3) Cohesive failure property: The adhesive sheet obtained in section (B) was cut into 15 mm width to obtain an adhesive tape. This adhesive tape was affixed to a steel plate surface polished with sandpaper (#280), and a 300°
The pressure was bonded by making one reciprocation at a speed of +n/min. After crimping, 40℃
After leaving it for 30 minutes or more, one end was immediately turned back 180° and forced peeling was performed at a constant speed of 1000/min. At this time, it was examined whether a portion of the adhesive remained on the surface of the steel plate. If adhesive remains, it is determined that cohesive failure has occurred.

(D) Evaluation of bactericidal properties of adhesive: The adhesive sheet obtained in section (B) was cut into a size of 8C11 x 8A11 to obtain 12 test pieces. 1 mil of bacterial cell fluid containing about 1.2 x 10' pieces of E. coli (7 ml) was sprayed almost evenly onto the adhesive surface of each of the four test pieces. This is 36
℃, one test piece was collected after 0.1 hour, and 5CD
It was washed out into LP broth and the number of viable bacteria therein was measured. After 0.5 hours, 1 hour, and 2 hours, the test pieces sprayed with the bacterial body fluid were collected one by one, and the number of viable bacteria was measured in the same manner. The respective values are shown in Table 1. Pseudomonas aeruginosa and Staphylococcus aureus were also tested in the same manner instead of E. coli. The results are shown in Table 1.

As a comparative example, a pressure-sensitive adhesive having the following composition having water-soluble properties was prepared and the same test was conducted. The results are shown in Table 1.

Polyvinylpyrrolidone (■kollidon-ni-90
; Trade name) 100 parts by weight Diglycerin 60 parts by weight Table 1 (E) Structure of various adhesive sheets or tapes 2 The adhesives obtained using the copolymer obtained in this example are as shown in section (D). It has excellent bactericidal properties. In addition to adhesive sheets or tapes whose main purpose is sterilization, adhesive sheets or tapes for various uses can be prepared by taking advantage of their excellent adhesiveness and hydrophilicity. Various configurations of pressure-sensitive adhesive sheets or tapes obtained using the copolymer of this example and their preferred uses are shown below.

(1) (Constitution) Base material: polyurethane film with a thickness of 40 μm Adhesive composition: 100 parts by weight of copolymer, 50 parts by weight of Jigurya 9F Adhesive layer thickness: 25 μm (Preferred use) ■ Wound protection <By applying directly to the wound, it protects the wound and prevents infection.

(To promote healing) ■ Large (100cj or more) bandage (dressing tape) with gauze in the center used for treating relatively large wounds ■ Surgical drapes of various sizes ■ Protection and healing after skin transplant surgery Promote ■ Fixation of intravenous injection/artificial dialysis needles, catheters, colostomies, etc. in designated locations ■ Prevention of abrasions such as shoes and bedsores (2) (Composition) Base material: 130 μm thick rayon fiber non-woven adhesive Composition: 100 parts by weight of copolymer, 45 parts by weight of diglycerin
Thickness of adhesive layer by weight: 2458 m (Suitable applications) ■ Rolled bandage ■ For closing small wounds and wounds after minor surgery ■ Dressing with medium and small size gauze ■ Intravenous injection needle 2 Specified for artificial dialysis needles, catheters, etc. Fixation in place ■ Removal of facial wrinkles 1 Beauty purposes such as hair buns (3) (Composition) Base material: 60 μm thick non-plasticized soft polyvinyl chloride (■
Nismezoika ■ (trade name); softness equivalent to DOP 4Qphr) Adhesive composition: 100 parts by weight of copolymer, Jiguriya 9F 40
Adhesive layer thickness by weight: 35μm (Suitable applications) ■Plastic-wrapped adhesive plaster■ Medium and small size (200- or less) surgical drape■ Dressing for wound care■ Intraoral adhesive plaster■ Intravenous needle 9 Artificial dialysis Securing needles, catheters, etc. in designated places ■ Fixing medical devices such as electrocardiograph electrodes 9 colostomies in designated parts of the human body ■ Preventing shoe and bedsores and protecting abraded surfaces (4) (Configuration ) Base material: acetate woven fabric with sealing and undercoating processing (warp: approx. 80 threads/inch, weft approximately 70 threads/inch) (copolymerization of butyl acrylate and diacetone acrylamide as sealing/priming agent) Adhesive composition: 100 parts by weight of copolymer, 35 parts by weight of Jigguse
Thickness of adhesive layer by weight: 60 μm (preferred use) ■ Cloth-wrapped adhesive plaster ■ External support, fixation and protection of fractured areas 9 Human body correction areas ■ Intravenous injection needles 9 Specified locations for artificial dialysis needles, catheters, etc. ■ Fixation of various medical components such as colostomy and electrodes for testing ■ Fixation of ends of sanitary products such as diapers (5) (Composition and use) Treatment adhesive with various therapeutic agents mixed into the adhesive Use as a sheet or tape.

As the base material, for example, the soft polyvinyl chloride film used in (3) can be used. Table 2 shows examples of compositions of drugs and adhesives used in such therapeutic adhesive sheets or tapes.

(Left below) Sum (A) Preparation of copolymer: 100 g of 2(methacryloxy)ethyltrimethylammonium chloride as a (meth)acrylic acid ester derivative (first copolymerization component),
30g of diacetone acrylamide as the second copolymerization component
, 2-ethylhexyl acrylate 5 as the third copolymerization component
A copolymer was prepared in the same manner as in Example 1 (A) using 0.02 g of 1,6-hexane glycol diacrylate as a polyfunctional monomer, and 75 g of methyl alcohol as a solvent. However, the amount of catalyst used is 0.54
It was set as g.

The resulting reaction solution was a milky white viscous liquid.

The concentration of the copolymer contained was 38.3%, and the viscosity at 21'C was about 35.0OOcps. When the polymerization rate was calculated from the residual monomer ratio, the total copolymer was 99.2%, the first copolymer component was 99.2%, the second copolymer component was 100%, and the third copolymer component was 99.2%. is 98.7
%Met. Similarly to Example 1 (A), when this reaction solution was diluted with toluene or ethyl acetate, the polymer components coagulated and precipitated, and it was possible to dilute it to an arbitrary concentration with alcohol, water, or the like.

(B) Preparation of adhesive sheet: The polymer obtained from the copolymer solution obtained in section (A) of this example.

It was a hard, slightly brittle resin-like material with no adhesive.

Diglycerin was added as a plasticizer to the copolymer solution obtained there. Appropriate tackiness was obtained when 40 to 80 parts by weight of diglycerin was added to 100 g of the polymer component. A pressure-sensitive adhesive solution was obtained by adding 9255 parts by weight of Jigguse to 100 g of the polymer component of the copolymer solution obtained in Section (A) of this example. A pressure-sensitive adhesive sheet was prepared using this pressure-sensitive adhesive solution according to the method described in Example 1 (B).

(C) Physical Properties of Adhesive Substitute for Adhesive Adhesive (Second Example) The physical properties of adhesive substitute were investigated using the pressure-sensitive adhesive sheet obtained in Section (B). 180
``Folded hocho adhesion strength is 820g/15mm.

The ball tack value was 22, and no cohesive failure was observed.

(D) Evaluation of bactericidal properties of adhesive: Example 1 Evaluation was carried out according to section (D). The results are shown in Table 3.

Table 3 (E) Structure of various pressure-sensitive adhesive sheets or tapes: It is possible to prepare pressure-sensitive adhesive sheets or tapes for various uses using the pressure-sensitive adhesive obtained using the copolymer obtained in this example. Its configuration and usage are shown in Example 1 (E)
According to section.

Preparation of main (A) copolymer: 80 g of 3(acrylamido)isopentyltrimethylammonium chloride and 30g of 2(methacryloxy)ethyltrimethylammonium chloride as the (meth)acrylamide derivative (first copolymerization component), 30 g of diacetone acrylamide as a polymerization component.

According to Example 1 (A) using 40 g of vinyl acetate as the third copolymerization component, 0.03 g of polyethyl glycol dimethacrylate (molecular weight: 336) as the polyfunctional monomer, and 80 g of methyl alcohol as the solvent. A copolymer was prepared. However, the amount of catalyst used is 0.54
It was set as g. The resulting reaction solution was a nearly transparent viscous liquid. The copolymer concentration was 40.3%.

The viscosity of the copolymer contained at 21°C is approximately 36,0OO
It was cps. The polymerization rate of the entire copolymer was 99.
3%.

Among the first copolymerization components, 3 (acrylamido)isopentyltrimethylammonium chloride is 99.6%, 2
(methacryloxy)ethyltrimethylammonium chloride is 99.8%, the second copolymerization component is 100%,
The third copolymerization component was 98.0%. Similarly to Example 1 (A), when this reaction solution was diluted with toluene or ethyl acetate, the polymer components coagulated and precipitated, and it was possible to dilute it to an arbitrary concentration with alcohol, water, or the like.

(B) Preparation of adhesive sheet: The polymer obtained from the copolymer solution obtained in section (A) of this example was a relatively tough resin-like material. Therefore, polymer component 1 of the copolymer solution
An adhesive solution was obtained by adding 60 parts by weight of Jigguse 9F to 00g. Example 1 (B) using this adhesive solution
A pressure-sensitive adhesive sheet was prepared according to the method described in section 1.

(C) Physical Properties of Adhesive Substitute for Adhesive Adhesive (Second Example) The physical properties of adhesive substitute were investigated using the pressure-sensitive adhesive sheet obtained in Section (B). 180
'The adhesive force of the folded paper is 850g/15mm.

The ball tack value was 24, and no cohesive failure was observed.

(D) Evaluation of bactericidal properties of adhesive: Example 1 Evaluation was carried out according to section (D). The results are shown in Table 4.

Table 4 (E) Structure of various pressure-sensitive adhesive sheets or tapes: It is possible to prepare pressure-sensitive adhesive sheets or tapes for various uses using the pressure-sensitive adhesive obtained using the copolymer obtained in this example. Its structure and use are in accordance with Example 1 (E).

1. Preparation of copolymer (A): (meth)acrylamide derivative (first copolymerization component), 40g of 3(acrylamide)propyltrimethylammonium chloride, second
40 g of N-vinyl-2-pyrrolidone as a copolymerization component,
Example 1 was carried out using 60 g of butyl acrylate and 30 g of vinyl acetate as the third copolymerization components, 0.01 g of trimethylolpropane (trimethacrylate) as the polyfunctional monomer, and 75 g of ethyl alcohol as the solvent.
A copolymer was prepared according to section (A). However, the amount of catalyst used was 0.45 g. The obtained reaction solution was a slightly yellow transparent viscous solution, and the concentration of the copolymer contained was 3.
2.6%, viscosity at 21°C was 2B+0OOcps. The polymerization rate was 98.5% for the entire copolymer;
Copolymerization component: 98.8%, second copolymerization component: 98.4%
, butyl acrylate accounts for 98.1% of the third copolymer component.
, vinyl acetate was 99%. When toluene or ethyl acetate was added to this solution, it became cloudy and became emulsified. The polymer did not coagulate and precipitate. It was possible to dilute to any concentration using alcohol.

When water was added, no change was observed up to about half the amount of the reaction solution, but emulsification occurred beyond that amount.

Therefore, it was found that the degree of hydrophilicity of the copolymer of this example was not as great as that of the copolymers obtained in Examples 1 to 3.

(B) Preparation of adhesive sheet: The amount of plasticizer added to the copolymer obtained in section (A) of this example is preferably about 0% less than that in Examples 1 to 3. This example (A)
An adhesive solution was obtained by adding 35 parts by weight of diglycerin to 100 g of the polymer component of the copolymer solution obtained in Section 3. A pressure-sensitive adhesive sheet was prepared using this pressure-sensitive adhesive solution according to the method described in Example 1 (B).

(C) Adhesive substitute physical properties of adhesive: Adhesive substitute physical properties were investigated using the adhesive sheet obtained in section (B) of this example. 18
The 0° folded binding force is 740g/15nv+.

The ball tack value was 20, and no cohesive failure was observed.

(D) Evaluation of bactericidal properties of adhesive: Example 1 Evaluation was carried out according to section (D). The results are shown in Table 5.

Table 5 (E) Structure of various pressure-sensitive adhesive sheets or tapes (2) It is possible to prepare pressure-sensitive adhesive sheets or tapes for various uses using the pressure-sensitive adhesive obtained using the copolymer obtained in this example. Its configuration and usage are shown in Example 1 (E)
However, it is mainly used when the main purpose of the sheet or tape is not to have a bactericidal effect, or when the hydrophilicity of the adhesive does not need to be very high. For example, Example 1 (
It is suitably used for bandages, drapes, or dressing sheets and tapes as shown in (3) of section E). It is also suitably used for therapeutic adhesive sheets or tapes containing drugs.

! Construction (A) Preparation of copolymer = 20 g of 2-hydroxy-3-methacryloxypropyltrimethylammonium chloride as the (meth)acrylic acid ester derivative (first copolymerization component), N-vinyl-2- as the second copolymerization component 20 g of pyrrolidone and 30 g of diacetone acrylamide, 110 g of butyl acrylate as a third copolymerization component, and 0.01 g of tetramethylolmethanetetraacrylate as a polyfunctional monomer.

Then, a copolymer was prepared according to Section (A) of Example 1 using 80 g of isopropyl alcohol as a solvent. However, the amount of catalyst used was 0.45 g, and isopropyl alcohol was used as the diluent solvent. The obtained reaction solution was transparent, and the concentration of the copolymer contained was 33.0%.
The viscosity at 21°C was 31.000 cps. The polymerization rate is 98.5% for the entire copolymer, 98.5% for the first copolymer component, 99.1% for N-vinyl-2-pyrrolidone among the second copolymer components, and 1% for diacetone acrylamide.
00%, and the third copolymerization component was 97.9%. Add ethyl acetate to this solution.

Although it becomes slightly cloudy, it can be mixed and diluted at any ratio. By adding alcohol, it was possible to freely dilute and dissolve. When water was added, the mixture became cloudy and became emulsified.

Therefore, it was found that the degree of hydrophilicity of the copolymers obtained in Examples 1 to 4 was not very high.

(B) Preparation of pressure-sensitive adhesive sheet: The copolymer obtained in Section (A) of this example had some tackiness and exhibited properties intermediate between those of a pressure-sensitive adhesive and a resin. When used as an adhesive, the amount of plasticizer required is 20 to 100 parts by weight of the polymer component.
It was 35 parts by weight. Jigguse 92
20 parts by weight was added to obtain an adhesive solution. A pressure-sensitive adhesive sheet was prepared using this pressure-sensitive adhesive solution according to the method described in Example 1 (B).

(C) Adhesive substitute physical properties of adhesive: Adhesive substitute physical properties were investigated using the adhesive sheet obtained in section (B) of this example. 180
'The adhesive force of the folded notebook is 620g/15mm+.

The ball tack value was 18, and no cohesive failure was observed.

(D) Evaluation of bactericidal properties of adhesive: Example 1 Evaluation was carried out according to section (D). The results are shown in Table 6.

Table 6 (E) Composition of various adhesive sheets or tapes: The adhesive using the copolymer obtained in this example is used for medical purposes that require appropriate adhesiveness, rather than for applications whose main purpose is sterilization. Can be used for adhesive sheets or tapes. Even if water comes into contact with such a sheet or tape after it is pasted, the adhesive absorbs water to an appropriate extent. Also, the sheet or tape will not peel off due to absorption of water.

Using such an adhesive, for example, a sheet or tape having the configurations (2) to (5) in Section (E) of Example 1 is prepared. Such sheets or tapes are used as bandages, as well as for fixing intravenous injection needles and artificial dialysis needles and catheters; fixing medical devices to specific parts of the human body; fixing sanitary materials (using double-sided tape); It is also used as an internal bandage. It is also suitably used as various types of adhesive sheets or tapes for transdermal treatment in which a drug is incorporated into the adhesive.

(Effects of the Invention) According to the present invention, it has the excellent characteristics of acrylic adhesives such as excellent adhesiveness, high internal cohesive force, and is resistant to deterioration, and also has excellent bactericidal properties (antibacterial properties). ) is obtained which can form a medical adhesive. When the sheet or tape of the present invention provided with such an adhesive layer is applied to the skin.

For example, microbial infection of the wound does not occur, and therefore
Healing may be accelerated. There is no rash caused by secondary sensitization of microorganisms to areas where stuffiness occurs.

Also the adhesive. Because of its excellent hydrophilicity, it is possible to adhere the sheet or tape to wet (5 damp) skin surfaces, and it will not peel off easily even if you sweat during application. This adhesive has excellent water absorption and water vapor permeability, so
Even if the sheet or tape is applied to the skin for a long time, it hardly gets stuffy, and therefore rashes due to stuffiness are unlikely to occur.

Even if the adhesive protrudes to the surrounding area when the sheet or tape is applied, or if the adhesive remains on the skin after peeling off, it can be easily washed and removed with water. Water-soluble drugs can be dissolved in the adhesive at high concentrations. Therefore.

It is now possible to easily obtain a therapeutic adhesive sheet or tape containing a high amount of water-soluble drugs, which has been difficult to prepare in the past.

Furthermore, since the adhesive itself is conductive, it has a strong antistatic effect, so for example, when a roll of adhesive tape is rewound, static electricity may cause it to stick to unintended objects, or there is a risk of ignition due to spark discharge. do not have.

Such medical adhesive sheets or tapes.

In addition to being used as a sheet or tape-like bandage to protect injured areas and fix fractures, etc.1
For example, when administering an intravenous drip, the intravenous needle is fixed to the skin surface, and medical equipment such as a colostomy is fixed in place.
It is also suitably used for adhesion. It can also be used for drapes during surgery. It can also be used as a patch containing various drugs, and in particular, a patch containing a high content of water-soluble drugs can be easily obtained. It is also used for cosmetic purposes such as smoothing out deep wrinkles on the face and fixing and shaping hair.

that's all

Claims (1)

[Scope of Claims] 1. A resin made of a copolymer containing a first copolymer component and a second copolymer component, wherein (1) the first copolymer component comprises (a) quaternary ammonium A saturated hydrocarbon group with a salt (
A saturated hydrocarbon group having a (meth)acrylamide derivative substituted with one of the active hydrogen atoms of meth)acrylamide and/or (b) a quaternary ammonium salt is (
It is a (meth)acrylic acid ester derivative substituted with the active hydrogen atom of meth)acrylic acid; and (2) the second copolymerization component is vinylpyrrolidone and/or diacetone acrylamide, which is used for medical adhesives. resin. 2. The first copolymerization component is contained in the copolymer at a ratio of 5 to 70% by weight, and the second copolymerization component is contained at a ratio of 30% or more by weight of the remaining components of the first copolymerization component. The resin according to claim 1. 3. The resin according to claim 1, wherein the copolymer contains a (meth)acrylic acid alkyl ester and/or a fatty acid vinyl ester as a third copolymerization component. 4. In the copolymer, the third copolymer component is 50% by weight of the remaining components of the first copolymer component and the second copolymer component.
The resin according to claim 3, which is contained in the above proportion. 5. A medical adhesive sheet or tape having an adhesive layer provided on at least one side of a base material, the adhesive comprising a copolymer resin containing a first copolymer component and a second copolymer component. (1) the first copolymerization component has (a) a saturated hydrocarbon group having a quaternary ammonium salt (
A saturated hydrocarbon group having a (meth)acrylamide derivative substituted with one of the active hydrogen atoms of meth)acrylamide and/or (b) a quaternary ammonium salt is (
A medical adhesive sheet or tape, which is a (meth)acrylic acid ester derivative substituted with an active hydrogen atom of meth)acrylic acid; and (2) a second copolymer component is vinylpyrrolidone and/or diacetone acrylamide. 6. The first copolymer component is contained in the copolymer in a proportion of 5 to 70% by weight, and the second copolymer component is contained in a proportion of 30% or more by weight of the remaining components of the first copolymer component. The sheet or tape according to claim 5. 7. The sheet or tape according to claim 5, wherein the copolymer contains a (meth)acrylic acid alkyl ester and/or a fatty acid vinyl ester as a third copolymer component. 8. In the copolymer, the third copolymer component is 50% by weight of the remaining components of the first copolymer component and the second copolymer component.
The sheet or tape according to claim 7, which is contained in the above proportion. 9. The sheet or tape according to claim 5, wherein the adhesive contains a plasticizer having an affinity for water. 10. The adhesive contains 50 to 100% by weight of the copolymer.
The sheet or tape according to claim 9, containing the plasticizer in a proportion of 50 to 0% by weight. 11. The sheet or tape according to claim 5, wherein the adhesive contains a drug.