JPS61226061A - Catheter stayed in blood vessel - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to an intravascular indwelling catheter for continuously injecting an infusion into a blood vessel.

(Prior Art and Problems) In recent years, hypertonic calorie infusions have been widely used in the treatment of elderly and malnourished patients. For such treatment, an intravascular indwelling catheter consisting of a tube body with open ends and a hub fixed to one end of the tube body is used. This catheter has an infusion outlet at its tip, so when administering an infusion through the catheter, the infusion mixes with blood at the outlet of the catheter. As a result, infections and other complications may follow, such as venous irritation depending on the components of the infusion, inflammation or edema with possible venous rupture. Phlebitis may also occur due to hypertonicity of the infusion.

In addition, the tube body used in this type of catheter is made of natural rubber, synthetic rubber such as poly-cis-isoprene rubber, or synthetic resin such as polyethylene, polypropylene, or tetrafluoroethylene. Because it has poor affinity with living tissues, there is a risk of thrombus formation on the tube surface, especially at the tube outlet.

(Means for Solving the Problems) Therefore, an object of the present invention is to provide an intravascular indwelling IW catheter that is highly safe and free from risks such as thrombosis and infection.

The intravascular indwelling catheter of the present invention has an average pore diameter of 0.02 to 2.
A blood vessel characterized in that the tip of a hollow fiber made of a hydrophilic polymer in which a large number of micropores of μ are substantially uniformly arranged in a cross section is closed with a resin, and the other end is fixed to a hub. Internally indwelling catheter (Example) Next, an embodiment of the intravascular indwelling catheter of the present invention will be described with reference to the drawings. As shown in FIG. 1, the catheter of the present invention includes a hydrophilic hollow fiber 1 whose tip end is closed with a resin 3 and whose other end is open, and the open end of the hollow fiber is connected with an adhesive 4. It consists of a fixed hub 2.

This hydrophilic hollow fiber 1 is made by reacting polyvinyl alcohol, ethylene vinyl alcohol copolymer, polyhydroxyethyl methacrylate, and each of these polymers with glutaraldehyde, formaldehyde, etc.
Alternatively, the surface of hollow fibers made of hydrophilic polymers such as polyacetylcellulose and polyacrylonitrile, or hollow fibers made of hydrophobic polymers such as polypropylene, 3-polytetrafluoroethylene, polyethylene, polystyrene, and polysulfone, is made hydrophilic. It has been processed.

Examples of hydrophilic treatment include chemical treatment such as sulfonation, and treatment with ethanol, surfactants, and the like.

Hydrophilization of hollow fibers made of hydrophobic polymers refers to hollow fibers that have been made hydrophilic to the extent that water can be naturally sucked into their pores by capillary action.

Furthermore, the hollow fibers used in the present invention have an average pore diameter of 0.02 to 2μ.
The micropores are arranged substantially uniformly in the cross section. Substantially uniform means that the membrane has micropores with approximately the same diameter throughout the entire thickness, and the diameter changes stepwise or continuously from one side of the membrane to the other in the range of 0.02 to 2μ. Includes items that have.

By using such hollow fibers, fine particles, bacteria, etc. contained in the infusion can be removed.

Hollow fibers usually have a thickness of 50 to 3000μ and a film thickness of 10 to 5.
00μ is used.

The hollow fibers described above can be manufactured by conventional spinning techniques. For example, polyvinyl alcohol-based hollow fibers can be produced by the method described in JP-A-52-21420.

The tip opening of the hollow fiber 1 is closed with resin 3.

As this resin, biocompatible resins such as silicone resins and polyurethane resins are used. The other end of the hollow fiber is fixed to the hub 2 with an adhesive 4.

In order to prevent leakage of infusion fluid from the portion of the catheter exposed outside the blood vessel, it is preferable to coat the surface of that portion with resin 5. As such a resin, it is preferable to use a biocompatible resin such as polyurethane, silicone, or polyhydroxyethyl methacrylate. Various methods can be used to form a coating layer of the resin on the surface of the catheter, such as applying the resin solution obtained by dissolving it in an appropriate solvent to the catheter,
Alternatively, there are methods such as blow drying or immersing the catheter in the above solution and then drying.On the other hand, in the case of highly hydrophilic hollow fibers, those with excellent permeability tend to have inferior strength. Therefore, after using a catheter made of such hollow fibers, when the catheter is taken out of the body, the hollow fibers may be cut and the cut pieces may remain in the body. In order to prevent the cut pieces from remaining in the body, as shown in FIG.
One end is fixed and the filament is extended along the hollow fiber, and the other end is locked to the open end of the hollow fiber such as a spherical body or a square body having a diameter larger than the inner diameter of the hollow fiber. Preferably, it is fixed to the member 7. By fixing the filamentous body to the resin that closes the opening at the tip of the hollow fiber in this way, even if the hollow fiber is cut when the catheter is taken out, the cut piece can be easily taken out. Instead of fixing one end of the thread to the locking member 7, one end of the thread may be fixed to the inner wall of the hub. As the locking member 7, biocompatible polyurethane resin or the like is usually used. Furthermore, the above-mentioned filamentous body must be selected from one that does not have any effects on living organisms such as toxicity. Usually, metal wires such as stainless steel wires, synthetic fibers such as nylon, polyester, etc. are used. It is preferable to use a helical metal wire as the filamentous body because the bending strength of the hollow fiber can be reinforced. In this case, one end of the helical metal wire is fixed to the resin 3 that closes the tip of the hollow fiber, and the other end is fixed to the hub 2.

The catheter described above is placed in the blood vessel 10 as shown in FIG. One end of an infusion set (not shown) is connected to a hub 2 provided at the end of the catheter, and infusion fluid is introduced into the catheter from an infusion bottle using a head difference. The infusion fluid introduced into the catheter leaks into the blood vessel through all the micropores formed in the wall of the hollow fibers and mixes into the blood.

(Effects of the Invention) As described above, since the vascular indwelling catheter of the present invention uses porous hollow fibers with closed tips, the infusion fluid leaks from the entire surface of the hollow fibers, so the infusion fluid is rapidly dispersed on the surface of the hollow fibers. This can reduce the incidence of phlebitis and reduce the risk of thrombus formation due to the formation of an infusion layer on the surface of the hollow fibers. Furthermore, since the micropores in the wall of the hollow fibers act as a filter, it has the excellent effect of preventing infection.

[Brief explanation of the drawing]

1 and 2 are cross-sectional views of the intravascular reservoir catheter of the present invention, and FIG. 3 is an explanatory view showing the state of use of the catheter of the present invention.

Claims (1)

[Scope of Claims] 1. The tip of a hydrophilic hollow fiber in which a large number of micropores with an average pore diameter of 0.02 to 2 μm are arranged substantially uniformly in the cross section is closed with a resin, and An intravascular indwelling catheter characterized by having an end fixed to a hub. 2. The intravascular indwelling catheter according to claim 1, wherein the surface of the portion of the hollow fiber exposed outside the blood vessel is coated with a resin.