JPS61141862A - Edible slow-releasing granule - Google Patents
Edible slow-releasing granuleInfo
- Publication number
- JPS61141862A JPS61141862A JP59265580A JP26558084A JPS61141862A JP S61141862 A JPS61141862 A JP S61141862A JP 59265580 A JP59265580 A JP 59265580A JP 26558084 A JP26558084 A JP 26558084A JP S61141862 A JPS61141862 A JP S61141862A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- coating
- granules
- granule
- shellac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008187 granular material Substances 0.000 title claims abstract description 32
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 40
- 239000011248 coating agent Substances 0.000 claims abstract description 23
- 238000000576 coating method Methods 0.000 claims abstract description 23
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 20
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 20
- 239000011718 vitamin C Substances 0.000 claims abstract description 20
- 229920001800 Shellac Polymers 0.000 claims abstract description 10
- 239000004208 shellac Substances 0.000 claims abstract description 10
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims abstract description 10
- 229940113147 shellac Drugs 0.000 claims abstract description 10
- 235000013874 shellac Nutrition 0.000 claims abstract description 10
- 229920002494 Zein Polymers 0.000 claims abstract description 7
- 239000005019 zein Substances 0.000 claims abstract description 7
- 229940093612 zein Drugs 0.000 claims abstract description 7
- 150000004676 glycans Chemical class 0.000 claims abstract description 6
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 6
- 239000005017 polysaccharide Substances 0.000 claims abstract description 6
- 238000013268 sustained release Methods 0.000 claims description 11
- 239000012730 sustained-release form Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 abstract description 8
- 238000000034 method Methods 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 5
- 238000003287 bathing Methods 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 239000004014 plasticizer Substances 0.000 description 3
- -1 but in this case too Substances 0.000 description 2
- 239000007931 coated granule Substances 0.000 description 2
- 239000011247 coating layer Substances 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000007922 dissolution test Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229920003124 powdered cellulose Polymers 0.000 description 1
- 235000019814 powdered cellulose Nutrition 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
【発明の詳細な説明】
（技術分野）
本発明はビタミンＣを徐放する顆粒に関し、その顆粒は
主として食品配合用に使用されるものである。DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to granules for sustained release of vitamin C, and the granules are mainly used for food formulations.
（従来技術と課題）
ビタミンＣ（アスコルビン晒）は１９７０ 年代になっ
て多くの研冗がなされ、生体を正常に維持する上でＭｅ
な位置を占めていることがわかってきた。通常ヒトの血
漿中のビタミンＣＪｉは一足であるが疲労、高熱作業、
ず０木、・手術後及び喫煙によってそのバランスが崩れ
るので、これを補給することが必登である。また、今日
の食生活で化学物質や食品箔加物等の所謂生体異物を摂
堆する機会が多くなっているが、この場合もビタミンＣ
の賛求量が増加する。(Prior art and issues) Vitamin C (ascorbic bleaching) has undergone much research in the 1970s, and has been shown to be a medicinal agent in maintaining the normal body.
It has become clear that it occupies a significant position. Normally, the amount of vitamin CJi in human plasma is just one pair, but it can cause fatigue, high-temperature work,
Since the balance is disrupted after surgery and smoking, it is essential to replenish this balance. In addition, in today's diet, there are many opportunities to ingest so-called xenobiotics such as chemicals and food additives, but in this case too, vitamin C
The amount of approval will increase.
ところがヒトはビタミンＣの生合成能を欠くため、この
必要なビタミンＣ１に食事から摂るか、又はビタミンＣ
そのものを服用しなければならない。このようにしてヒ
トハその要求量に応じてビタミンＣを体に取入れなけれ
ばならないが、その性質上生体内マの吸収に多くの問題
を含んでいる。この問題とは、例えばこれを内服した時
、摂取量によって吸収率が異る。１００〜を投与したと
きの吸収率は８０〜９０ ％で、５？のときはおよそ２
０％であり、吸収されなかった残シは排泄されることに
なる。これはビタミンＣの通常の投与方法では、バイオ
アベイラビリティの低いことを意味している。これを解
決する第１の方法は、少量づつ回数をふやすことである
が、この方法は服用者にとって煩瑣であり、のみ忘れが
あるなど好ましくない。第２の方法としてＩ／′１服用
した製薬や食品が体中で徐々にビタノンＣを放出するよ
うにする方法が考えられる。However, humans lack the ability to biosynthesize vitamin C, so they must obtain this necessary vitamin C1 from their diet or use vitamin C.
Must take that. In this way, humans must take in vitamin C into their bodies according to their required amount, but due to its nature, there are many problems in the absorption of vitamin C in the body. The problem is that, for example, when this drug is taken internally, the absorption rate varies depending on the amount ingested. When 100~ was administered, the absorption rate was 80~90%, which was 5~. Approximately 2 when
0%, and the unabsorbed residue will be excreted. This means that vitamin C has low bioavailability using the usual administration method. The first method to solve this problem is to increase the number of doses taken in small doses, but this method is undesirable as it is cumbersome for the person taking the medication and may cause them to forget to take it. A second method is to make the medicine or food taken at I/'1 gradually release vitamin C in the body.
しかし、食品や食品添加物の範囲で放出を制御できる方
法はいまだ見出されていなくその所決が強く安値されて
いる。However, a method to control the release of food and food additives has not yet been found, and the price of this method is extremely low.
本発明省らはとの課ｊ＠を所決すべく鋭意検討を続けた
結果、食品に使用できる基剤を用いて、ビタミンＣ顆粒
をコーティングすることにより、これを徐放顆粒にして
放出速度を調節し、吸収率を者しくたかめることに成功
した。As a result of intensive studies to determine the issue with the Ministry of the Invention and others, we found that by coating vitamin C granules with a food-grade base, we could turn them into sustained-release granules and increase the release rate. We succeeded in adjusting the absorption rate and increasing the absorption rate.
（本発明のｅｓｔＩＪＸ、及び効果）
本発明の要旨は「ビタミンＣを含有する顆粒の表面に粉
末状の多糖類を分散状に含有するセラックまたはゼイン
を被覆してなる可食性徐放性顆粒」である。即ち、本発
明は被膜形成剤のコーテイング液とコーティング粉末と
の組合せによって成就されたものである。コーテイング
液単独でコーティングする場合は粒子同志の付着がある
うえ、造膜性も恐く被膜形成剤（セラック又はゼイン）
のコーテイング量と溶出時間との相関関係を見出すこと
ができず浴出時間の制御ができない。即ち、顆粒表面の
コーティング層の厚みが不均一なため、コーティング層
（コーテイング膜）が悼端に博い個庁ができ１浴出時間
がコーティングしないものと殆んど変らない様な顆粒と
なる。これを避けるため、大量の被膜形成剤を施すと、
全くビタミンＣを放菖しない顆粒となってしまい溶出時
間の調節は不可能である。しかし、これに多糖類の粉末
を併用してコーティングすることにより造膜補強、付着
防止、静電防止、浴出調節等の効果を示し、多糖類の配
合量及びコーテイング量とビタミンＣ浴出率に相関性を
見出すことができ、任意の徐放性顆粒とすることができ
る。(ESTIJX and effects of the present invention) The gist of the present invention is "edible sustained-release granules formed by coating the surface of granules containing vitamin C with shellac or zein containing powdered polysaccharides in a dispersed state." It is. That is, the present invention was achieved by combining a coating liquid of a film-forming agent and a coating powder. When coating with a coating liquid alone, particles may adhere to each other, and the film-forming properties may also be poor.
It is not possible to find a correlation between the coating amount and the elution time, and the bathing time cannot be controlled. In other words, because the thickness of the coating layer on the surface of the granules is uneven, the coating layer (coating film) widens at the edges and forms individual areas, resulting in granules whose bathing time is almost the same as that without coating. . To avoid this, if a large amount of film forming agent is applied,
The resulting granules do not release any vitamin C, making it impossible to adjust the elution time. However, by coating this with polysaccharide powder, effects such as film reinforcement, adhesion prevention, static electricity prevention, and bath release adjustment were shown. A correlation can be found between the two and can be made into any sustained release granules.
本発明において、セラック又はゼインが被膜形成剤とし
て１更用されるが、特にセラックが潰れている。また多
糖類としては、各棟デンプン、マンナン、ペクチン、ア
ラビアガム、トラガントカム、り７−、／ｌ／ム、ロー
カストビーンガム、微粉末セルロース等が例示されるが
特にデンプンが好ましい。コーテイング液はセラック又
はゼインをエタノール又は含水エタノール等に溶解して
調製したものを用いるが、これに可塑剤としてグリセリ
ン脂肪叡エステル（食砒）を冷加すると造膜性が向上し
て好適である。In the present invention, shellac or zein is used as a film-forming agent, especially shellac is crushed. Examples of the polysaccharide include starch, mannan, pectin, gum arabic, tragacanthcum, ri7-, locust bean gum, and finely powdered cellulose, with starch being particularly preferred. The coating liquid used is one prepared by dissolving shellac or zein in ethanol or aqueous ethanol, etc., and it is preferable to add glycerin fatty acid ester (food arsenic) as a plasticizer to this liquid to improve film-forming properties. .
不発明の可食性徐放性顆粒に使用される被膜形成剤の童
はコーティングする前の顆粒に対して、０．２〜２０菫
１チ好ましくは１〜ｌｔｌ量チである。本発明の可食性
徐放性顆粒に使用される多糖類の粉末はコーティング前
の顆粒に対して１〜３０ ｍ １％が用いられるが特に
２〜１５ ｍ ｉｔ ％が好ましい。また、可塑剤とし
て使用されるグリセリン脂肪散エステルは顆粒に対して
０．１〜１０．０重＊Ｓ、史に好ましくは０．１〜２ｍ
１１チが使用される。セラック又はゼインの溶媒にはエ
タノール又は含水エタノールが適しているが、これらに
限定されず、これらの被膜形成剤を浴解し且適当な揮発
性を有する無害な液体を使用することが出来る。The amount of film-forming agent used in the edible sustained-release granules of the present invention is 0.2 to 20 ml, preferably 1 to 1 tl, per granule before coating. The polysaccharide powder used in the edible sustained-release granules of the present invention is used in an amount of 1 to 30 m 1%, but preferably 2 to 15 m 1%, based on the granules before coating. In addition, the glycerin fatty dispersion ester used as a plasticizer is 0.1 to 10.0 weight*S to the granule, preferably 0.1 to 2 m
11 is used. Suitable solvents for shellac or zein include, but are not limited to, ethanol or aqueous ethanol, and any non-hazardous liquid that dissolves these film-forming agents and has suitable volatility can be used.
なお、本発明の可食性徐放性顆粒はそれを構成する組成
よりみて食品として利用することができるが医薬品とし
ての効果も併せ持っていることは云うまでもない。It goes without saying that the edible sustained-release granules of the present invention can be used as foods due to their composition, but they also have effects as pharmaceuticals.
以下本発明の可食性徐放性顆粒の実施例につき、その製
法並びにその効果に関する試験について述べる。然しな
から、本発明はこの記載により限定されるものではない
。Examples of the edible sustained-release granules of the present invention will be described below, as will the manufacturing method and tests regarding their effects. However, the present invention is not limited to this description.
実施例
■ 顆粒の製造
下記の処方によりフロイント産業（株）製の遠心流動型
コーティング装＆ＣＦ−３６０型（以下ＣＦ装置と略称
する）を用いて、ビタミンＣ２５％含有の７〜ｌυメツ
シユの球形顆粒を遺シ、６０℃ １時間乾燥した。Example ■ Manufacture of granules Spherical granules of 7 to lυ mesh size containing 25% vitamin C were prepared using a centrifugal flow type coating device & CF-360 model (hereinafter abbreviated as CF device) manufactured by Freund Sangyo Co., Ltd. according to the following recipe. It was then dried at 60°C for 1 hour.
記
ビタミンＣ粉末 ２５０１ノ
ンバレル（フロイン）ｋＭｉｔ製） ２００
ｆケ 糖（蔗 糖） ５０
０ ｔバインダー用グラニュー糖 ５
０１稍製水 ５０２
註：上記のノンバレルとは白Ｓが主成分の原型顆粒であ
る。Vitamin C powder 2501 non-barrel (Froin) kMit) 200
f Sugar (sucrose) 50
0 t Granulated sugar for binder 5
01 Sake Water 502 Note: The above non-barrel is a prototype granule whose main component is white S.
■ コーティング
■で得た球形顆粒１０００１ ′ｆ：、ＣＦ装置に入れ
毎回第１−＄ｃに示す各処方に従いコーテイング液と粉
末デンプンをそれぞれ別のフィーダーより上記装置内に
噴精状に吹込み常法によりコーティングしてａ −ｆの
６８ｉ６の本発明の実施？ｌｌ（可食性徐放性顆粒）を
作成した。又比較例１ （ｆ）として粉末状の多ａＩ類
を使用せず、セラックと可塑剤全含むコーテイング液の
みでコーティングしたものを作成した。■ Coating ■ Spherical granules 10001 'f: were placed in a CF device and each time the coating liquid and powdered starch were blown into the device from separate feeders in the form of jets according to each recipe shown in No. 1-$c. Implementation of the present invention by coating a-f 68i6 according to the method? ll (edible sustained release granules) was prepared. Further, as Comparative Example 1 (f), a product was prepared in which powdered multi-alpha compound was not used and the coating was coated only with a coating liquid containing shellac and a plasticizer.
第 １ 表
注：ａ−ｆは本発明の実施例 ｇＦｉ比較例１■ 溶出
試験
上述の■と■の操作によって得られたコーティングされ
た顆粒（ａ−ｇ）と■の操作で製造されたま＼でコーテ
ィングされてない顆粒（ｈ）につき溶出試験器（Ｄ−Ｔ
ａ２Ｏ型 日本分光社！Ｒ）のバスケット法により日本
薬局法′ｊＪ、ｌｉｔ用いて浴出率を測定した。なお、
上記のコーティングされてない顆粒は比較例２と呼ぶこ
ととする。浴出試験の条件は液温３７±２℃、バスケッ
ト回転速度１００ ｒｐｍ 、便用ｉ／［：ｔ９００ｍ
ｊ、吸光度２５４ ｎｍである。得られたａ−ｆ（実施
例）及びｇ−ｈ（比軟１Ｐ１１）のテスト結果は第１図
のごとく、それぞれ１〜６時間でほぼ１００チの溶出率
を示しており、セラック及びトウモロフンデンプンのコ
ーテイング量とビタミンＣの溶出率との間に相関関係の
あることが判明し、任意の徐放性順′Ｂ、を得ることが
可能でおることを示している。Table 1 Note: a-f are Examples of the present invention gFi Comparative Example 1 ■ Dissolution test Coated granules (a-g) obtained by the above operations ■ and ■ and coated granules produced by the procedure ■ Dissolution tester (D-T) for uncoated granules (h)
A2O type Nippon Bunkosha! The bathing rate was measured by the basket method of R) using the Japanese Pharmacopoeia method'jJ, lit. In addition,
The uncoated granules described above will be referred to as Comparative Example 2. The conditions for the bathing test were: liquid temperature 37±2℃, basket rotation speed 100 rpm, toilet i/[:t900m
j, absorbance at 254 nm. As shown in Figure 1, the test results of a-f (example) and g-h (specifically soft 1P11) each showed a dissolution rate of approximately 100 in 1 to 6 hours. It has been found that there is a correlation between the coating amount of starch and the elution rate of vitamin C, indicating that it is possible to obtain any sustained release order 'B'.
第１図は実施例ａ ｒ ｂ ＨＣ＋ ｄ ｇ ｅ及びｆ
並びに比較例ｇ及びｈの各顆粒についての時間の経過に
伴うビタミンＣの浴出率の変化を示す図である。
代理人 弁理士 堀 正 雄
−りつ
手続補正曹（自発）
昭和ｊり年１２月３１日FIG. 1 shows examples a r b HC+ d g e and f.
Also, it is a diagram showing changes in the bathing rate of vitamin C over time for each of the granules of Comparative Examples g and h. Agent: Patent Attorney Tadashi Hori (Volunteer) December 31, 1929
Claims (1)
を分散状に含有するセラックまたはゼインを被覆してな
る可食性徐放性顆粒。1 Edible sustained-release granules formed by coating the surface of granules containing vitamin C with shellac or zein containing dispersed powdered polysaccharides.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59265580A JPS61141862A (en) | 1984-12-17 | 1984-12-17 | Edible slow-releasing granule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59265580A JPS61141862A (en) | 1984-12-17 | 1984-12-17 | Edible slow-releasing granule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61141862A true JPS61141862A (en) | 1986-06-28 |
Family
ID=17419093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59265580A Pending JPS61141862A (en) | 1984-12-17 | 1984-12-17 | Edible slow-releasing granule |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61141862A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01296953A (en) * | 1988-05-24 | 1989-11-30 | Freunt Ind Co Ltd | Vitamin c composition, feed containing said composition added thereto and production thereof |
| US5160742A (en) * | 1991-12-31 | 1992-11-03 | Abbott Laboratories | System for delivering an active substance for sustained release |
| WO2000064277A1 (en) * | 1999-04-26 | 2000-11-02 | Imperial Sensus, L.L.C. | Granular delivery system |
| US6361827B1 (en) | 1997-12-26 | 2002-03-26 | Showa Sangyo Co., Ltd. | Method of imparting water resistance to molded polysaccharide |
| JP2006061025A (en) * | 2004-08-24 | 2006-03-09 | Sumioka Shokuhin Kk | Sugar-coated granule and method for producing the same |
| JP2007089519A (en) * | 2005-09-29 | 2007-04-12 | Nof Corp | Method for producing coated powder |
| WO2020221574A1 (en) * | 2019-04-30 | 2020-11-05 | Dsm Ip Assets B.V. | New delivery system for specific water-soluble vitamins |
| JP2021052751A (en) * | 2019-09-30 | 2021-04-08 | 備前化成株式会社 | Solid oral composition containing polysaccharide |
-
1984
- 1984-12-17 JP JP59265580A patent/JPS61141862A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01296953A (en) * | 1988-05-24 | 1989-11-30 | Freunt Ind Co Ltd | Vitamin c composition, feed containing said composition added thereto and production thereof |
| US5160742A (en) * | 1991-12-31 | 1992-11-03 | Abbott Laboratories | System for delivering an active substance for sustained release |
| US6361827B1 (en) | 1997-12-26 | 2002-03-26 | Showa Sangyo Co., Ltd. | Method of imparting water resistance to molded polysaccharide |
| WO2000064277A1 (en) * | 1999-04-26 | 2000-11-02 | Imperial Sensus, L.L.C. | Granular delivery system |
| JP2006061025A (en) * | 2004-08-24 | 2006-03-09 | Sumioka Shokuhin Kk | Sugar-coated granule and method for producing the same |
| JP2007089519A (en) * | 2005-09-29 | 2007-04-12 | Nof Corp | Method for producing coated powder |
| WO2020221574A1 (en) * | 2019-04-30 | 2020-11-05 | Dsm Ip Assets B.V. | New delivery system for specific water-soluble vitamins |
| JP2021052751A (en) * | 2019-09-30 | 2021-04-08 | 備前化成株式会社 | Solid oral composition containing polysaccharide |
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