JPS6112618A - Dermal drug for external use - Google Patents
Dermal drug for external useInfo
- Publication number
- JPS6112618A JPS6112618A JP13416584A JP13416584A JPS6112618A JP S6112618 A JPS6112618 A JP S6112618A JP 13416584 A JP13416584 A JP 13416584A JP 13416584 A JP13416584 A JP 13416584A JP S6112618 A JPS6112618 A JP S6112618A
- Authority
- JP
- Japan
- Prior art keywords
- benzoyl peroxide
- polypropylene glycol
- external use
- dissolved
- dermal drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title abstract description 4
- 229940079593 drug Drugs 0.000 title abstract 3
- 230000002500 effect on skin Effects 0.000 title abstract 3
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000004342 Benzoyl peroxide Substances 0.000 claims abstract description 25
- 235000019400 benzoyl peroxide Nutrition 0.000 claims abstract description 25
- 229920001451 polypropylene glycol Polymers 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract description 6
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract description 3
- 239000001630 malic acid Substances 0.000 abstract description 3
- 235000011090 malic acid Nutrition 0.000 abstract description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract description 2
- 239000003963 antioxidant agent Substances 0.000 abstract description 2
- 239000002738 chelating agent Substances 0.000 abstract description 2
- 239000003906 humectant Substances 0.000 abstract description 2
- 150000007522 mineralic acids Chemical class 0.000 abstract description 2
- 230000009965 odorless effect Effects 0.000 abstract description 2
- 150000007524 organic acids Chemical class 0.000 abstract description 2
- 230000001590 oxidative effect Effects 0.000 abstract description 2
- 238000006116 polymerization reaction Methods 0.000 abstract description 2
- 239000007787 solid Substances 0.000 abstract description 2
- 239000000600 sorbitol Substances 0.000 abstract description 2
- 230000009967 tasteless effect Effects 0.000 abstract description 2
- 239000002562 thickening agent Substances 0.000 abstract description 2
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 206010039580 Scar Diseases 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- -1 IPA Chemical compound 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- QYIXCDOBOSTCEI-UHFFFAOYSA-N alpha-cholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 QYIXCDOBOSTCEI-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］ 一
本発明は過酸化ベンゾイルとポリプロピレングーリコー
ルとを含有することを特徴とする過酸化ベンゾイルが溶
解された皮膚外用剤に関する。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to an external preparation for skin in which benzoyl peroxide is dissolved, which is characterized by containing benzoyl peroxide and polypropylene glycol.
［従来の技術］
６０年以上の間、過酸化ベンゾイルは火傷、静脈瘤性潰
瘍、尋當性毛唐、皮脂漏および座癒などの皮膚創傷の局
所治療に使用されてきた。とくに、表皮剥離作用および
抗菌作用は有効であり、座庶の治療剤として汎用されて
いる。BACKGROUND OF THE INVENTION For more than 60 years, benzoyl peroxide has been used for the topical treatment of skin wounds such as burns, varicose ulcers, hair rashes, seborrhea and acne scars. In particular, it has effective epidermal exfoliating and antibacterial effects, and is widely used as a therapeutic agent for acne scars.
［発明が解決しようとする問題点コ
しかしながら、過酸化ベンゾイルは溶媒に極めて溶解し
にくいので製品中に配合しようとする場合には懸濁状態
で配合せざるをえず、このために外観を考慮して乳化状
にしたり、沈降を防止するため系にある程度以上の粘度
を持たせなければならないなど、製品形態にかなりの制
約を受けているのが現状である。[Problems to be solved by the invention] However, benzoyl peroxide is extremely difficult to dissolve in solvents, so if it is to be incorporated into a product, it must be incorporated in a suspended state. At present, there are considerable restrictions on product form, such as the need to make an emulsified product or to provide a system with a certain level of viscosity to prevent sedimentation.
本発明者らはこのような事情にかんがみ、上記の欠点を
解決すべく鋭意研究を重ねた結果、過酸化ベンゾイルと
ともにポリプロピレングリコールを配合したならば、過
酸化ベンゾイルを系中に溶解し得ることを見いだし、本
発明を完成するに至った。In view of these circumstances, the inventors of the present invention have conducted extensive research to solve the above-mentioned drawbacks, and have found that if polypropylene glycol is blended with benzoyl peroxide, benzoyl peroxide can be dissolved in the system. This discovery led to the completion of the present invention.
［問題点を解決するための手段および作用］すなわち、
本発明は、下記２成分を含有することを特徴とする過酸
化ベンゾイルが溶解された皮膚外用剤である。[Means and actions for solving the problem] That is,
The present invention is an external preparation for skin in which benzoyl peroxide is dissolved, which is characterized by containing the following two components.
（ｉ）過酸化ベンゾイル （ｉｉ ）ポリプロピレングリコール 以下、本発明の構成について詳述する。(i) Benzoyl peroxide (ii) Polypropylene glycol Hereinafter, the configuration of the present invention will be explained in detail.
本発明で用いる過酸化ベンゾイルは無色、無臭、無味の
結晶性固体で、室温で安定である。過酸化ベンゾイルは
強い酸化作用を有するが人体には安全である。Benzoyl peroxide used in the present invention is a colorless, odorless, and tasteless crystalline solid that is stable at room temperature. Although benzoyl peroxide has a strong oxidizing effect, it is safe for the human body.
本発明で用いられるポリプロピレングリコールはプロピ
レングリコールが重合したもので重合度は２〜７０（分
子量約１３０〜４０００）までのものであり、これらの
うちから任意の一種又は二種以上が選ばれて用いられる
。The polypropylene glycol used in the present invention is a polymerized propylene glycol with a degree of polymerization of 2 to 70 (molecular weight approximately 130 to 4000), and any one or more of these may be selected and used. It will be done.
過酸化ヘンジイルの配合量は皮膚外用剤全量中の０．０
０１〜４重量％である。The amount of hendiyl peroxide is 0.0 in the total amount of the skin external preparation.
01 to 4% by weight.
ポリプロピレングリコールの配合量は過酸化ベンゾイル
の２０重量倍以上であることが好ましい。The amount of polypropylene glycol blended is preferably at least 20 times the weight of benzoyl peroxide.
本発明の皮膚外用剤には上記の必須構成成分に加えて、
必要に応じて、通當医薬品、化粧品分野で用いられるそ
の他の成分、例えばＥＤＴＡなどのキレート化剤、ＢＨ
Ｔ、ヒドロキノン、トコフェロールなどの酸化防止剤、
ソルビトール、グリセリンなどの保湿剤、エタノール、
ＩＰＡなどのアルコール、クエン酸、乳酸、リンゴ酸な
どの有機酸、リン酸などの無機酸、増粘剤、水などを配
合することができる。当然のことながら、これらの成分
は本発明の効果を損なわない質的量的範囲内で用いられ
なければならない。In addition to the above-mentioned essential components, the skin external preparation of the present invention includes:
If necessary, other ingredients used in the pharmaceutical and cosmetic fields, such as chelating agents such as EDTA, BH
Antioxidants such as T, hydroquinone, and tocopherol,
Humectants such as sorbitol and glycerin, ethanol,
Alcohols such as IPA, organic acids such as citric acid, lactic acid, and malic acid, inorganic acids such as phosphoric acid, thickeners, water, etc. can be blended. Naturally, these components must be used within a qualitative and quantitative range that does not impair the effects of the present invention.
［実施例］ つぎに、実施例により本発明をさらに詳細に説明する。[Example] Next, the present invention will be explained in more detail with reference to Examples.
本発明はこれにより限定されるものではない。The present invention is not limited thereby.
配合量は重量％である。The blending amount is in weight%.
実施例１ （重量％）■
過酸化ベンゾイル ４．０■ポ
リプロピレングリコール（分子量１０００） ９６．
０■に■を加え、室温にて攪拌溶解した。Example 1 (weight%) ■
Benzoyl peroxide 4.0 ■Polypropylene glycol (molecular weight 1000) 96.
■ was added to 0■, and the mixture was stirred and dissolved at room temperature.
実施例２ （重量％）■過
酸化ベンゾイル ２．５■ポリ
プロピレングリコール（分子量４０００） ９７．５
■に■を加え、室温にて攪拌溶解した。Example 2 (wt%) ■ Benzoyl peroxide 2.5 ■ Polypropylene glycol (molecular weight 4000) 97.5
(2) was added to (2), and the mixture was stirred and dissolved at room temperature.
実施例３ （重量％）■過
酸化ベンゾイル １．０■ジプ
ロピレングリコール ９９．０■に■
を加え、室温にて攪拌溶解した。Example 3 (% by weight) ■ Benzoyl peroxide 1.0 ■ Dipropylene glycol 99.0 ■ ■
was added and dissolved with stirring at room temperature.
実施例４ （重量−）■過
酸化ベンゾイル １．０■ポリ
プロピレングリコール〈分子量２０００＞ 、９０．
０■ポリプロピレングリコール（分子量３０００）
９．０■■を混合Ｌ７、これに■を加えて室温で攪拌
溶解した。Example 4 (Weight -) ■ Benzoyl peroxide 1.0 ■ Polypropylene glycol <molecular weight 2000>, 90.
0 ■ Polypropylene glycol (molecular weight 3000)
9.0 ■■ was mixed in L7, and ■ was added thereto, and the mixture was stirred and dissolved at room temperature.
実施例５ （重量％）■過
酸化ベンゾイル ２・５■ポ
リプロピレングリコール（分子量１０００） ９６．
４４■ザリチル＠
０．０１■乳酸
０．０５■楕製水
１．０■に■■を加えて攪拌溶解し、この溶液を、■
に■を加えて攪拌した溶液中へ添加して溶解した。Example 5 (wt%) ■ Benzoyl peroxide 2.5 ■ Polypropylene glycol (molecular weight 1000) 96.
44 ■ Zarichil @
0.01 ■ Lactic acid
0.05 ■ Oval water
Add ■■ to 1.0■, stir and dissolve, and add this solution to ■
was added to the solution and dissolved in the stirred solution.
実施例６ （重量％）■過
酸化ベンゾイル ２．５■ポリ
プロピレングリコール（分子量１０００） ８１．８
２■グリセリン ０．
２■クエン酸
０．０１■リン酸
０．０２０精製水
１．０■に■、を加えて攪拌溶解し、つぎに■を
加えて攪拌溶解する。この溶液中に、■に■を攪拌溶解
した溶液を加えて攪拌溶解する。さらに、■■を加えて
攪拌溶解した。Example 6 (wt%) ■ Benzoyl peroxide 2.5 ■ Polypropylene glycol (molecular weight 1000) 81.8
2 ■ Glycerin 0.
2 ■ Citric acid
0.01 ■ Phosphoric acid
0.020 purified water
Add (■) to 1.0 (■) and stir and dissolve, then add (■) and stir and dissolve. A solution obtained by stirring and dissolving ■ into ■ is added to this solution, and the mixture is stirred and dissolved. Furthermore, ■■ was added and dissolved with stirring.
実施例７ （重量％〉■過
酸化ベンゾイル ０．０５■ポ
リプロピレングリコール（分子１１０００） ５２．
３１■エタノール ３３
．４４■ジプロピレングリコール ３
．００グリセリン １
．５■コレスタノールのエチレン
オキサイド（３０モル）付加体
（日光ケミカルズ株式会社製ニンコールＤＨＣ−３０）
０．２
０グリセリルトリ −２−エチルヘキサノエート ２
．４■楕製水 ７．
１■に■を加えて攪拌溶解し、これに■と■のうらの２
．１重量％とを加えて攪拌溶解し、エタノール相とする
。別に、■■■を混合して加熱攪拌溶解し、これに■の
うちの０．７重量％を加えて攪拌溶解し、室温まで冷却
する。これに■と■の残部とを加えて攪拌して溶解する
。このものを先のエタノール相に加えて攪拌溶解した。Example 7 (% by weight) ■ Benzoyl peroxide 0.05 ■ Polypropylene glycol (molecules 11000) 52.
31■Ethanol 33
．． 44 ■ Dipropylene glycol 3
．． 00 Glycerin 1
．． 5 ■ Ethylene oxide (30 mol) adduct of cholestanol (Ninkol DHC-30 manufactured by Nikko Chemicals Co., Ltd.)
0.2 0 Glyceryl tri-2-ethylhexanoate 2
．． 4 ■ Oval water 7.
Add ■ to 1■, stir and dissolve, and add ■ and 2 behind ■.
．． 1% by weight was added and dissolved with stirring to form an ethanol phase. Separately, ■■■ are mixed, heated and stirred and dissolved, 0.7% by weight of ■ is added thereto, stirred and dissolved, and cooled to room temperature. Add ① and the remainder of ① to this and stir to dissolve. This product was added to the ethanol phase and stirred to dissolve.
［発明の効果］
実施例１〜７は、いずれも従来にはない過酸化ベンゾイ
ルが系中に溶解した皮膚外用剤であり、室温、１力月経
過後も沈澱などは発生せず安定性に優れていた。[Effects of the Invention] Examples 1 to 7 are all skin preparations in which benzoyl peroxide, which has never existed before, is dissolved in the system, and they are stable without precipitation even after 1 month at room temperature. It was excellent.
また、これらの皮膚外用剤は座連治療防止効果の点でも
良好なものであった。過酸化ベンゾイルが溶解されてい
ることにより有効表面積が最大に発揮されるので、従来
の懸濁タイプよりも薬効的に有利であると考えられる。In addition, these skin external preparations were also good in terms of their effectiveness in preventing the treatment of acne scars. Since the effective surface area is maximized by dissolving benzoyl peroxide, it is considered to be more medicinally advantageous than the conventional suspension type.
Claims (1)
ンゾイルが溶解された皮膚外用剤。 （ｉ）過酸化ベンゾイル （ｉｉ）ポリプロピレングリコール(1) An external skin preparation in which benzoyl peroxide is dissolved, which is characterized by containing the following two components. (i) Benzoyl peroxide (ii) Polypropylene glycol
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13416584A JPS6112618A (en) | 1984-06-29 | 1984-06-29 | Dermal drug for external use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13416584A JPS6112618A (en) | 1984-06-29 | 1984-06-29 | Dermal drug for external use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6112618A true JPS6112618A (en) | 1986-01-21 |
Family
ID=15121968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13416584A Pending JPS6112618A (en) | 1984-06-29 | 1984-06-29 | Dermal drug for external use |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6112618A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5445823A (en) * | 1994-10-20 | 1995-08-29 | The Procter & Gamble Company | Dermatological compositions and method of treatment of skin lesions therewith |
-
1984
- 1984-06-29 JP JP13416584A patent/JPS6112618A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5445823A (en) * | 1994-10-20 | 1995-08-29 | The Procter & Gamble Company | Dermatological compositions and method of treatment of skin lesions therewith |
| US5932228A (en) * | 1994-10-20 | 1999-08-03 | The Procter & Gamble Company | Dermatological compositions and method of treatment of skin lesions therewith |
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