JPS6060854A - Base agent for poultrice - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] The present invention relates to an improved patch base.

Patch agents are used by being attached to the skin for a long period of time. Therefore, as essential conditions for an ideal patch, it must satisfy the following various requirements.

1) The base material must have excellent temperature resistance and be flexible regardless of summer or winter.

2) It must have sufficient water retention to keep the application site moist for a long time.

3) It must be an aqueous base that absorbs sweat, which causes rashes, well.

4) The aqueous base pl-( should be neutral to weakly acidic with little skin irritation.

5) When spreading the paste on the support, it should be spread evenly.

Conventionally, various aqueous bases have been proposed to meet these demands, and most of them have utilized the thermoplasticity of gelatin for shape retention and spreadability. For example, JP-A-5
No. 7-181020 discloses a gelatin-based pulp paste composition characterized by containing an acrylic acid ester latex or a vinyl acetate-ethylene latex and a polyacrylate.

Although gelatin-based agents have good properties overall, they are easily affected by changes in temperature, and as temperatures rise in the summer, they soften, causing an unpleasant stickiness when applied to the skin, and may temporarily cause problems during the distribution process. Due to exposure to high temperatures, there are problems with discoloration and oozing due to aging of the base, and furthermore, when the temperature drops in winter, it hardens and lacks adhesion to the skin.

The present invention solves the problems of gelatin-based bases, and provides a base for patches that maintains constant adhesion to the skin regardless of the season, and that satisfies all of the above requirements. It is.

That is, the base of the present invention contains 5 to 40 polyhydric alcohols by weight.
parts, sodium polyacrylate 1-10 parts, sodium carboxymethylcellulose 1-10 parts, aluminum compound 0.01-30 parts, polyacrylic ester 1-10 parts
10 parts, water 10 to 80 parts, and the pal is adjusted to 5 to 8'' with acid.

Due to its thermoplasticity, gelatin is used as an important ingredient to impart spreadability to the base during the manufacture of patches and to impart shape retention to the manufactured patches. Regarding a poultice containing an acid ester latex and a polyester 11-ruate salt, the above-mentioned Japanese Patent Application Laid-Open No. 57-1
The presence of gelatin was thought to be essential, as in the pulp agent described in No. 81020.

According to the present invention, by blending each component in the above ratio, it is possible to obtain spreadability and shape retention properties that are not dependent on the thermoplasticity of gelatin, and to obtain a patch base that has stable adhesiveness throughout the seasons. It will be done.

In addition, in the present invention, since gelatin is not used, there is no need to heat the product to 40° to 50° during production, which has the advantage of eliminating the reduction in content due to volatilization of the active ingredient.

The shape retention of the base material in the present invention V is mainly due to the crosslinking reaction between sodium polyacrylate and aluminum compound in the presence of moisture, and its excellent shape retention at high temperatures is significantly greater than that of conventional gelatin bases. different. Sodium polyacrylate has an average degree of polymerization of about 10,000 to 10
0,000 can be used, but especially an average polymerization degree of about 15
,000 to about 60,000 are preferred.

Examples of aluminum compounds that can be used in the crosslinking reaction of sodium polyacrylate include activated alumina, synthetic aluminum silicate, aluminum hydroxide, and kaolin.

Cellulose derivatives such as sodium carboxymethyl cellulose are used to give texture to the base material due to their water-retaining and moisture-retaining properties, and also to enhance adhesiveness when wet, which is one of the characteristics of the base material of the present invention. In addition, it is possible to eliminate the disadvantage of conventional adhesive patches, which is the decrease in adhesive strength during sweating, and also to eliminate the decrease in initial adhesive strength due to the separation of water content from the base.

Bo-11ac+1 acid ester is added to the base to maintain good initial tackiness and long-term tackiness when wet.

Polyacrylic esters that can be used include emulsion copolymers consisting of 85 to 95 parts by weight of 2-ethylhexyl acrylate and 5 to 15 parts by weight of methyl acrylate, or 85 to 95 parts by weight of 2-ethylhexyl acrylate and acetic acid. Examples include emulsion copolymers made of 5 to 15 parts by weight of vinyl.

Polyhydric alcohol is used as a humidifying agent for the base material in order to maintain its flexibility for a long time after use. Polyhydric alcohols that can be used include glycerin, nrubitol, furopyrenge 11col, and ethylene glycol.

By adjusting the pH of the base to 5 to 8 with an acid, active ingredients such as salicylic acid ester compounds can be stably contained in the patch for a long time. The pH of the base agent is the pH of the skin surface.
Since it is close to K, skin irritation that causes side effects such as rash is reduced.

To adjust the pH, it is preferable to use organic acids such as tartaric acid and citric acid.

It is important to use the amounts of each of these components in the proportions mentioned above; if the amounts are outside of that range, good water retention, shape retention, and cohesiveness of the base will not be obtained.

In addition to the above-mentioned components, the base of the present invention contains components conventionally used as a pasting base, such as adhesives such as gum arabic, white inorganic pigments such as kaolin and titanium oxide, and starch and sodium polyacrylate. A super absorbent resin such as a copolymer, a surfactant such as Bon 11 Rubate 80, etc. may be added as appropriate.

In order to produce a patch using the base of the present invention, an essential oil component such as methyl salicylate is added to the base of the present invention.
Or add other ingredients that can be expected to have medicinal effects through transdermal absorption, knead them uniformly at a temperature of 10 to 30°C, and add polyacrylic acid. Using thixotropy, cotton cloth,
It is manufactured by spreading it evenly to a constant thickness on a support such as a nonwoven fabric, and covering the surface with a plastic film.

The base material of the present invention is a synthetic polymer compound with almost no thermoplasticity, so its adhesion to the skin remains almost constant even when the atmospheric temperature changes, and its performance remains unchanged even after long-term storage. Almost no change.

Furthermore, the base of the present invention has excellent temperature resistance, and even when stored at a high temperature around 60° for a long time, the base does not age and lose its cohesive strength.

Furthermore, since the base of the present invention has a very stable cohesive force, the retained liquid such as water does not seep out from the back side of the support. In addition, the base does not remain on the skin surface due to aging and losing its cohesive strength.
In this respect as well, the base of the present invention is completely different from conventional products.

Next, the results of testing the properties of a poultice (hereinafter referred to as a poultice according to the present invention) using the base of the present invention in comparison with conventional products will be explained. The compositions of the bag agent according to the present invention and the conventional product used in the test are shown in Table 1 below.

Table 1 Tartaric acid 0.5 05 − − “−Rien
Acid -05--- Sodium polyacrylate 2.5 81J 10. O
i, 5 5.0 Poor Yasikuri) Lele υ Risan 2 Scolding Hit 1 Shiro 0 3.0 3.0 2.0 5. Q Methylcellulose 2. Q --2,0-Super water absorbent resin -1,Q
-2,0 Activated alumina Q, 3 - - - -Synthetic silicate inopenium -〇, S---Kaolin 20.0
10.0 5.0 - 5.0 lbitol 10.
0. ' -10,020,0 Polyac 11 Neu Limb Eslapure 3.0 2.0 - - - Gelatin
- -10,05,01Q,0 sesquiolei 4-rubitan 0,1 0.1 0.1 0.2 -Polysorbate 80 o,3 o,5 0.3 - 0.2・Base of Example 1 described later Use: The base material of Example 2 described later was used. The adhesion test was carried out by cutting into lengths of 10 crn on a slope at 30° to the horizontal using a tester as shown in Figures 1 and 2. Place sample 1 with the sticky side facing up. Upper 7C
In the mz lower part 13cWL, cardboards 2 and 3 matching the thickness of the sample are arranged and fixed. Diameter 63 mm, weight 1.
A 0g steel ball is rolled on the top edge of the slope, and the time it takes to reach the bottom edge of the adhesive surface in the center is measured and the adhesive strength is measured. At this time, the room temperature should be kept at 20@±1° and the adhesive surface of the sample and the steel ball should not be touched by hand. Steel pole used once: Wash with warm water, dry, then wash with Penzol and dry thoroughly before use.

Six types of samples are used immediately after being stored in a 5', 20°, and 40° thermostat for 24 hours. The test results were as shown in Table 2 below.

In the severe test, immediately after production, the product was placed in a sealed bag made of aluminum foil, stored in a thermostat at 6o° for 5 weeks, and then observed for aging, discoloration, and oozing. The results were as shown in Table 3.

Table 3 Results of Severity Test Next, examples of the present invention will be shown, but the present invention is not limited to these examples only.

Example 1 2.5 parts of sodium polyacrylate, 3 parts of sodium carboxymethyl cellulose, and 2 parts of methyl cellulose were dissolved in 50 parts of 7. A suspension of 05 parts of tartaric acid dissolved in 12.7 parts of water and 10 parts of glycerin, 10 parts of sorbitol, and 20 parts of kaolin is added and kneaded. Next, add 03 parts of activated alumina to 3 parts of polyacrylic acid ester.
The base material was prepared by adding a suspension of 50% and kneading it uniformly.

Example 2 8 parts of sodium polyacrylate, 3 parts of sodium carboxymethyl cellulose, and 1 part of super absorbent resin are dissolved in 59 parts of water. Next, a suspension of 10 parts of kaolin and 0.5 parts of synthetic aluminum silicate in 30 parts of glycerin is added and kneaded. Furthermore, 2 parts of polyester 1j acid ester was added and kneaded uniformly, which was used as a base.

Reference Example 1 The base material prepared in Example 1 was prepared by adding 4.6 parts of the following medicinal ingredients and 04 parts of surfactant to 95 parts of the base obtained in Example 2, kneading them uniformly, and then preparing the support. The drug surface is then covered with a plastic film to form a bag.

cR-Camphor 1 part l-menthol 15 parts Methyl salicylate 2 parts Diphenhydramine 01 part Rubitan sesquioleate 1 part Polynorbate 80 Q
As explained above, the base material of the present invention is composed of easily available components, and not only has extremely superior performance compared to other base materials, but is also less susceptible to temperature changes.
It is an excellent product that can maintain constant quality for a long period of time.

[Brief explanation of the drawing]

Figure 1 shows a side view of the tester used in the adhesion test, and Figure 2 shows a plan view of Figure 1.

Claims (1)

[Claims] (5 to 40 parts of polyhydric alcohol, 1 to 10 parts of sodium polyacrylate, 1 to 10 parts of sodium carboxymethyl cellulose, 1 to 10 parts of aluminum compound, 1 to 1 parts)
30 parts, polyacrylic acid ester 1-10 parts, water 140 parts
-80 parts, and the pH is adjusted to 5 to 8 with an acid. (2) The active fraction is a component that can be expected to have medicinal effects through transdermal absorption, such as methyl salicylate, glycol salicylate, etc., 1j thyl acid ester compounds, and acidic nonsteroidal anti-inflammatory agents such as ifflofen and flurbiprofen. A patch according to claim 1.