JPS6043046B2 - gelatin capsules - Google Patents
gelatin capsulesInfo
- Publication number
- JPS6043046B2 JPS6043046B2 JP4980879A JP4980879A JPS6043046B2 JP S6043046 B2 JPS6043046 B2 JP S6043046B2 JP 4980879 A JP4980879 A JP 4980879A JP 4980879 A JP4980879 A JP 4980879A JP S6043046 B2 JPS6043046 B2 JP S6043046B2
- Authority
- JP
- Japan
- Prior art keywords
- caramel
- capsules
- condensed phosphate
- gelatin
- titanium dioxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007903 gelatin capsule Substances 0.000 title claims description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 30
- 235000013736 caramel Nutrition 0.000 claims description 30
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 claims description 29
- 229910019142 PO4 Inorganic materials 0.000 claims description 25
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 20
- 239000010452 phosphate Substances 0.000 claims description 20
- 239000004408 titanium dioxide Substances 0.000 claims description 15
- 238000004040 coloring Methods 0.000 claims description 5
- 235000021317 phosphate Nutrition 0.000 description 21
- 239000002775 capsule Substances 0.000 description 15
- 108010010803 Gelatin Proteins 0.000 description 14
- 229920000159 gelatin Polymers 0.000 description 14
- 239000008273 gelatin Substances 0.000 description 14
- 235000019322 gelatine Nutrition 0.000 description 14
- 235000011852 gelatine desserts Nutrition 0.000 description 14
- 239000000243 solution Substances 0.000 description 8
- 235000013305 food Nutrition 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 235000019646 color tone Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- -1 invert sugar Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- 101000831686 Drosophila melanogaster Protein cycle Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 101000740484 Homo sapiens Aryl hydrocarbon receptor nuclear translocator-like protein 1 Proteins 0.000 description 1
- 101000640050 Homo sapiens Protein strawberry notch homolog 1 Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 102100033979 Protein strawberry notch homolog 1 Human genes 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 231100000045 chemical toxicity Toxicity 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007905 drug manufacturing Methods 0.000 description 1
- 239000000576 food coloring agent Substances 0.000 description 1
- 235000002864 food coloring agent Nutrition 0.000 description 1
- 238000012812 general test Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 229960004903 invert sugar Drugs 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 235000019828 potassium polyphosphate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000013094 purity test Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 230000021148 sequestering of metal ion Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 235000013555 soy sauce Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Description
【発明の詳細な説明】
本発明は、安全上問題がなく、着色の安定性良好であ
り、且つ実生産可能なゼラチンカプセルに関するもので
ある。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to gelatin capsules that have no safety problems, have good coloring stability, and can be produced commercially.
従来、カプセルにおいては、製剤の鑑別による誤用防
止および薬剤の製造時の便宜を主目的とし、契印な色調
による商品価値の向上を副次的な目的として、食品添加
物公定書に収載された合成タール色素単味又は、組合せ
混合成は、日本薬局方の規格に準拠する二酸化チタンと
の組合せによる着色が汎用されて来た。Conventionally, capsules have been made using synthetic chemicals listed in the Japanese Food Additives Official Standards, with the main purpose of preventing misuse through product identification and convenience during drug manufacturing, and with the secondary purpose of improving product value through distinctive color tones. Tar pigments alone or in combination with titanium dioxide in accordance with the standards of the Japanese Pharmacopoeia have been commonly used for coloring.
最近、学術の進歩向上により、合成タール色素中に好
ましからざる薬害を示すものが続々と見出され、人体へ
の安全性に関して不安視される社会状勢が強まつている
。Recently, as a result of advances in science, a number of synthetic tar pigments that exhibit undesirable chemical toxicity have been discovered one after another, and there is growing concern in society regarding their safety to the human body.
また、近時合成タール色素の代替品として食品に汎用
されている天然着色料が着目され、例えばカラメルを単
独あるいは二酸化チタンと一定の範囲で混合して用いら
れているが、この場合には、カラメルに明らかに肉眼で
認め得る黒褐色の微小な斑点を生じていた。Recently, attention has been paid to natural coloring agents commonly used in foods as substitutes for synthetic tar colorants. For example, caramel is used alone or mixed with titanium dioxide to a certain extent; in this case, The caramel had blackish brown minute spots that were clearly visible to the naked eye.
特に医薬用に供する場合、このような斑点は、異物と同
視され、一般的に著しく商品価値を損うという大きな問
題がある。 この点を改良すべく、鋭意検討の結果、縮
合リン酸塩を添加することにより、斑点の防止に成功し
、美しい色調と光沢を有し、熱、光に対し安定であり、
実生産条件下に於て良好なゼラチンカプセルが得られる
ことを見出した。 即ち、本発明は、カラメルと縮合リ
ン酸塩を均一に分散させ着色を行つたゼラチンカプセル
および、さらに二酸化チタンを添加したゼラチンカプセ
ルに関し、好ましくはカラメルの量が０．０５〜５．０
重量％、縮合リン酸塩の量が０．０１〜０．１重量％、
二酸化チタンの量が０．１〜３．０重量％であるゼラチ
ンカプセルに関するものである。Particularly when the product is used for medical purposes, such spots are considered to be foreign substances, and there is a big problem in that they generally significantly impair commercial value. In order to improve this point, as a result of intensive research, we succeeded in preventing spots by adding condensed phosphate, and it has a beautiful color tone and gloss, and is stable against heat and light.
It has been found that good gelatin capsules can be obtained under actual production conditions. That is, the present invention relates to gelatin capsules colored by uniformly dispersing caramel and condensed phosphate, and gelatin capsules further containing titanium dioxide, preferably in an amount of caramel of 0.05 to 5.0.
% by weight, the amount of condensed phosphate is 0.01-0.1% by weight,
The present invention relates to gelatin capsules in which the amount of titanium dioxide is 0.1 to 3.0% by weight.
上記のカラメルは、ブドウ糖、シヨ糖、転化糖、水ア
メ、デンプン加水分解物、糖ミツおよびその他の種類な
どの食品炭水化物を熱処理するか、或は、酸、アルカリ
又は、その他の食品炭水化物を少量加えて熱処理して得
られる物であり、ＦＡＯ／ＷＨＯ）アメリカおよびＥＣ
諸国に於て、食品着色料として許可されている。The above caramels are made by heat treating food carbohydrates such as glucose, sucrose, invert sugar, starch syrup, starch hydrolysates, molasses and other types, or by adding small amounts of acids, alkalis or other food carbohydrates. In addition, it is obtained by heat treatment, and is approved by FAO/WHO) America and EC.
It is permitted as a food coloring agent in some countries.
わが国に於ても、医薬品、清涼飲料水、製菓、醤油等広
く利用されている。縮合リン酸塩は、食品業界に於て金
属イオン封鎖剤、合成膨張剤の酸性成分等の目的に利用
され、第三版食品添加物公定書に収載されている。In Japan, it is widely used in medicines, soft drinks, confectionery, soy sauce, etc. Condensed phosphates are used in the food industry for purposes such as metal ion sequestering agents and acidic components of synthetic swelling agents, and are listed in the Third Edition of the Official Standards of Food Additives.
縮合リン酸塩の一般化学式は、Ｍｎ＋２ｐｎ０３ｎ＋１
又は（ＭＯＰ３）ｎで示され、Ｍはナトリウム、カリウ
ムなどのようなアルカリ金属、ｎは縮合度を示し、ピロ
リン酸ナトリウム、ポリリン酸ナトリウム、ポリリン酸
カリウム、メタリン酸ナトリウム等があるが、これらに
限定されるものではなく、その他各種の縮合リン酸塩の
使用が可能である。二酸化チタンは、日本薬局方適合品
を細末として利用すれば充分目的を達し得る。縮合リン
酸塩は、単味又は組合せ混合し、カラメルでの着色時に
於ける斑点発生防止の目的で添加するものであるが、縮
合リン酸塩のカラメルとの水溶液を作成し、これをゼラ
チンカプセル製造用のゼラチン原液に加える方法、カラ
メルであらかじめ着色したゼラチン液に縮合リン酸塩を
添加する方法、或は、縮合リン酸塩をあらかじめ添加し
たゼラチン液にカラメルを加える方法等、添加順序は特
に限定されない。The general chemical formula of condensed phosphate is Mn+2pn03n+1
or (MOP3) n, where M is an alkali metal such as sodium or potassium, and n indicates the degree of condensation, and there are sodium pyrophosphate, sodium polyphosphate, potassium polyphosphate, sodium metaphosphate, etc. Various other condensed phosphates can be used without limitation. If titanium dioxide is used in the form of a fine powder that complies with the Japanese Pharmacopoeia, the purpose can be fully achieved. Condensed phosphates are added alone or in combination to prevent spots from forming when coloring with caramel, but an aqueous solution of condensed phosphates and caramel is created and this is poured into gelatin capsules. The order of addition is particularly important, such as adding condensed phosphate to gelatin stock solution for manufacturing, adding condensed phosphate to gelatin solution pre-colored with caramel, or adding caramel to gelatin solution to which condensed phosphate has been added in advance. Not limited.
二酸化チタンも、添加の順に限定はなく、ゼラチン原液
に均一に分散するように添加すればよいから、二酸化チ
タンを均一に分散したゼラチン液に、カラメルと縮合リ
ン酸塩を加える方法、或は、カラメルと縮合リン酸塩で
あらかじめ着色したゼラチン液に二酸化チタンを分散さ
せる方法等、どのような方法でもよい。Titanium dioxide is also not limited to the order of addition, and can be added so as to be uniformly dispersed in the gelatin stock solution. Therefore, there is a method of adding caramel and condensed phosphate to a gelatin solution in which titanium dioxide is uniformly dispersed, or Any method may be used, such as a method in which titanium dioxide is dispersed in a gelatin solution that has been colored in advance with caramel and condensed phosphate.
ここに用いられるゼラチン溶液は、ゼラチンを熱湯に溶
解し、必要に応じて防腐剤を添加して調製される。The gelatin solution used here is prepared by dissolving gelatin in hot water and adding a preservative if necessary.
このゼラチン溶液の濃度は約３５重量％程度であり、粘
度は８００〜１００■ＰＳ（４５℃）である。均一に分
散を行なうには、特別な機械を要せず、公知の装置、方
法により分散を行なえば充分であり美しいカプセルを得
ることが出来る。また、カラメルは、ゼラチンカプセル
を加工機上で生産するために必要な可塑剤、保存剤、分
散剤、その他の添加剤の存在下に於ても、充分着色の目
的を達することが出来る。更に、成型加工したカプセル
は、褐色系統の色調を示すが、この色調は温度および光
に対して安定である。The concentration of this gelatin solution is about 35% by weight, and the viscosity is 800 to 100 PS (45°C). For uniform dispersion, no special machine is required; dispersion using known devices and methods is sufficient and beautiful capsules can be obtained. Furthermore, caramel can sufficiently achieve the purpose of coloring even in the presence of plasticizers, preservatives, dispersants, and other additives necessary for producing gelatin capsules on a processing machine. Furthermore, the molded capsules exhibit a brownish color, which is stable to temperature and light.
また、カプセルの色調は、使用するカラメルおよび二酸
化チタンの量により、連続的に変動させることができる
。Moreover, the color tone of the capsules can be continuously varied by the amounts of caramel and titanium dioxide used.
本発明にいうゼラチンカプセルは、第九改正日本薬局方
に定義されるカプセル（ＣａｐｓｕｌａｅＯｐｅｒｃｕ
ｌａｔａｅ）と同等の意義を有するものである。The gelatin capsules referred to in the present invention are capsules defined in the Ninth Edition Japanese Pharmacopoeia.
It has the same meaning as ``latae''.
即ち、縮合リン酸塩を混合したカラメルにより着色され
たカプセルは、安全性に於て問題なく、日本薬局方で定
められるカプセルの品質即ち、外観性状及び純度試験に
適合し、更に、一般試験法３３崩壊試験法により崩壊度
を試験しても、従前のカプセルと全く同様の崩壊度を示
し、医薬品用或は食品用として使用することが可能であ
る。In other words, the capsules colored with caramel mixed with condensed phosphate have no safety problems, meet the capsule quality, appearance, and purity tests stipulated by the Japanese Pharmacopoeia, and also pass the general test method. Even when the degree of disintegration was tested by the No. 33 disintegration test method, it showed exactly the same degree of disintegration as conventional capsules, and can be used for pharmaceuticals or foods.
以下、実施例及び比較例に基づき本発明をさらに詳細に
説明するが、これは本発明を制限するものではない。実
施例１
ゼラチンを熱湯に溶かし、濃度約３５重量％、粘度９０
０：）ＰＳ（４５、Ｃ）のゼラチン溶液を調製した。EXAMPLES Hereinafter, the present invention will be explained in more detail based on Examples and Comparative Examples, but these are not intended to limit the present invention. Example 1 Gelatin was dissolved in boiling water to give a concentration of about 35% by weight and a viscosity of 90%.
A gelatin solution of 0:) PS (45, C) was prepared.
”このゼラチン溶液にカラメルの水溶液および縮合リン
酸塩の水溶液を加え均一に混合した。ゼラチンに加えら
れたカラメルおよび縮合リン酸塩の量は第１表の通りで
ある。この混合物から常法により硬質カプセルを成形し
た。得られたカプセル．は、カラメルの添加配合量によ
り種々の透明で且つ、斑点のない良好な褐色系統の色調
を呈する。第１表から明らかなように、カラメルおよび
縮合リン酸塩を用いて着色したカプセルは、経時および
光等に対する安定性が極めて良好である。実施例２二酸
化チタンを水に均一に混合し、実施例１と同様にカラメ
ルおよび縮合リン酸塩により着色したカプセルを成形し
た。``To this gelatin solution, an aqueous solution of caramel and an aqueous solution of condensed phosphate were added and mixed uniformly.The amounts of caramel and condensed phosphate added to gelatin are shown in Table 1. Hard capsules were molded.The resulting capsules exhibit various transparent and spotless brownish tones depending on the amount of caramel added.As is clear from Table 1, caramel and condensed phosphorus Capsules colored with acid salts have extremely good stability over time and against light, etc. Example 2 Titanium dioxide was mixed uniformly with water and colored with caramel and condensed phosphates in the same manner as in Example 1. A capsule was molded.
加えられたカラメル、縮合リン酸塩および二酸化チタン
の量は第２表の通りである。得られたカラメルは、種々
の不透明で且つ、斑点のない良好な褐色系統の色調を呈
する。第２表から明らかなように、カラメル、縮合リン
酸塩および二酸化チタンを用いて着色したカプセルは、
経時および光等に対する安定性が極めて良好である。The amounts of caramel, condensed phosphate and titanium dioxide added are as shown in Table 2. The resulting caramel exhibits a good brownish color with varying opacity and no spots. As is clear from Table 2, capsules colored with caramel, condensed phosphate and titanium dioxide are
It has extremely good stability over time and against light.
比較例１
縮合リン酸塩を加えず、カラメルだけで着色したカプセ
ルを成形した。Comparative Example 1 Capsules colored only with caramel without adding condensed phosphate were molded.
ゼラチンに加えられたカラメルの量は第３表の通りであ
る。得られたカプセルは、種々の透明で褐色系統の色調
を呈するとともに、斑点を生じ、著しく商品価値を損う
ものであつた。第３表から明らかなように、縮合リン酸
塩の添加を行なわないと、カラメルの３．０重量％添加
時には斑点を生じた。The amount of caramel added to the gelatin is as shown in Table 3. The obtained capsules exhibited various transparent and brownish tones and had spots, which significantly impaired their commercial value. As is clear from Table 3, when 3.0% by weight of caramel was added without the addition of condensed phosphate, spots were produced.
比較例２
二酸化チタンを均一に混合し、比較例１と同様にカラメ
ルにより着色したカプセルを成形した。Comparative Example 2 Titanium dioxide was mixed uniformly and capsules colored with caramel were molded in the same manner as in Comparative Example 1.
Claims (1)
つたゼラチンカプセル。 ２ カラメルの量が０．０５〜５．０重量％、縮合リン
酸塩の量が０．０１〜０．１重量％である特許請求の範
囲第１項記載のゼラチンカプセル。 ３ カラメルと縮合リン酸塩に、さらに二酸化チタンを
添加して均一に分散させ着色を行つたゼラチンカプセル
。 ４ カラメル、縮合リン酸塩及び二酸化チタンの量が、
それぞれ、０．０５〜５．０重量％、０．０１〜０．１
重量％及び０．１〜３．０重量％である特許請求の範囲
第３項記載のゼラチンカプセル。[Claims] 1. A gelatin capsule colored by uniformly dispersing caramel and condensed phosphate. 2. The gelatin capsule according to claim 1, wherein the amount of caramel is 0.05 to 5.0% by weight, and the amount of condensed phosphate is 0.01 to 0.1% by weight. 3 Gelatin capsules made by adding titanium dioxide to caramel and condensed phosphate, uniformly dispersing it, and coloring it. 4 The amounts of caramel, condensed phosphate and titanium dioxide are
0.05-5.0% by weight, 0.01-0.1, respectively.
% by weight and from 0.1 to 3.0% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4980879A JPS6043046B2 (en) | 1979-04-24 | 1979-04-24 | gelatin capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4980879A JPS6043046B2 (en) | 1979-04-24 | 1979-04-24 | gelatin capsules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55141242A JPS55141242A (en) | 1980-11-05 |
| JPS6043046B2 true JPS6043046B2 (en) | 1985-09-26 |
Family
ID=12841424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4980879A Expired JPS6043046B2 (en) | 1979-04-24 | 1979-04-24 | gelatin capsules |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6043046B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2246072A (en) * | 1990-07-20 | 1992-01-22 | Egyt Gyogyszervegyeszeti Gyar | Pharmaceutical compositions stabilised against light |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4070459B2 (en) * | 1999-08-31 | 2008-04-02 | 中外製薬株式会社 | Soft capsule |
| JP3549522B1 (en) * | 2003-10-24 | 2004-08-04 | 日清ファルマ株式会社 | Coenzyme Q10-containing capsule |
| JP5143024B2 (en) * | 2007-01-12 | 2013-02-13 | クオリカプス株式会社 | Brown film composition and method for preparing the same |
-
1979
- 1979-04-24 JP JP4980879A patent/JPS6043046B2/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2246072A (en) * | 1990-07-20 | 1992-01-22 | Egyt Gyogyszervegyeszeti Gyar | Pharmaceutical compositions stabilised against light |
| GB2246072B (en) * | 1990-07-20 | 1994-06-15 | Egyt Gyogyszervegyeszeti Gyar | Solid pharmaceutical compositions containing a light sensitive active ingred ient and stabilised by a dye |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS55141242A (en) | 1980-11-05 |
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