JPS60261505A - Filtration device - Google Patents

Abstract

PURPOSE:To permit remote observation and grasping of filtration operation by constructing an ultrafiltration device with a filtration vessel having a fitting part of an injection needle at an outlet for conducting the filtrate, a slidable holder for supporting the vessel, and an adapter having a non-contact detector for detecting the dropping of the filtrate. CONSTITUTION:An introducing port 10 of an ultrafiltration device consisting of a filtration vessel 1 supporting a filtration membrane and an adapter 2 is connected with an automaticaly synthetic device. A Bayar bottle 14 is inserted and fitted to the adapter 2 and the relative position of the bottle 14 in a bottle holding part 15 to an injection needle 13 fitted to the outlet for conducting the filtrate in the filtration vessel 1 is decided under a condition when a movable part 16 is pulled out upward. The injection needle 13 is penetrated vertically through a rubber cap 141 of the Bayar bottle 14 by sliding the bottle holding part 15, and a tip end of the injection needle 13 is located in the light passage of a photoelectric detector 17. The dropping time interval of the filtrate is detected by the photoelectric detector 17, and when the interval becomes longer than a previously set time, the completion of filtration is decided.

Description

Detailed Description of the Invention (Aside from work! 1lIf) This invention is used as a terminal device for an automatic synthesis device for various compounds. The present invention relates to an ultrafiltration device suitable for ultrafiltration for ultrafiltration in which water can be irradiated.

(Background technology) In recent years, short-depletion J isotopes with a depletion period of several minutes to several tens of minutes have come to occupy an important position in the field of nuclear medicine, and these are currently being handled by mounting companies. The supply system has a small OT capacity. For this purpose, we used a cyclotron to create a short half-reduced costal nucleus at a general hospital, research laboratory, etc., and synthesized a 6-terminal naked green compound using an automatic 8-claw device IT, and used it in the soup industry. Adjustment has become essential. Short-life nuclear loincloths produced by a cyclotron are 150 (halved in M2 minutes) and 13N (halved in 10 minutes).
, +10 (20 minutes at the same time), "Ft at 110 minutes), etc., but the mother nucleus is supplied from the textile industry Eshagin, and the final product is already available in general hospitals, such as 99mTC obtained as its decay product. Even in the case of widely used radiopharmaceuticals, there are strong calls for thieves to steal radiopharmaceuticals and to make them available for purchase.

At a mounting company, etc., a specimen with large wrinkles of Jingjiang Industry Co., Ltd. is processed for a few minutes in a quality government underground facility, and there is no special procedure, but it is difficult to adjust the dosage at general hospitals and research institutes. It was difficult. In these places, synthesis is generally carried out using automatic synthesis equipment, but the automatic synthesis equipment is very small because it is installed in a hot cell. Sterilization of the pedestal system is extremely difficult. In particular, immobilized r
The labeling method using # element is rapid and yields well, and is suitable as an identification method for short-lived nuclear extraction, but its widespread use is hampered by the contamination of fugitive enzymes and the sterilization of the fixed # element column. Limited.

On the other hand, there are commercially available ultrafiltration membranes that can remove bacteria, R# accumulation, fever, and other polymers from scratches. I'm looking forward to it. However, the conventional FC filtration device 1t using this filtration membrane does not allow residual liquid wrinkles in each container. If you use a filter with a size of 0 - 1 small paper, which was not the same, the amount of remaining liquid will be reduced in proportion to the square of the amount of paper, but it will take time to filter, which will shorten your life. It becomes unsuitable for handling.

Furthermore, in order to handle radioactive nuclear extraction, sample synthesis and filtration must be performed remotely within a shielding wall, and furthermore, until after the extraction is completed, it is necessary to quickly handle the extraction at the temple, and the filtration status can be monitored remotely. It is detected that scales are detected.

(Objective of the Invention) The present invention aims to provide a sleeping area filtration device that is easy to handle and can easily and easily grasp the filtration status from a remote location, in order to satisfy the above-mentioned many types of water sprinkling requirements.

(Structure of the invention) This invention will be described below with reference to the drawings.

FIG. 1 shows one embodiment of the filtration device of the present invention. The filtration device supports the diaphragm and holds the filtration device 1 with the filtration and the capacity for accommodating the filtration liquid. It consists of an adapter 2 for storing it in a certain position on Mutsumi Kenkatani.

As shown in the exploded perspective view of Fig. 2, filtration acceptance 1 is #
A shallow cylindrical valley bottom part 3 with a lure slip male 4 at the center of the lower surface through which the liquid flows, a support plate 5 made of a stainless steel net and a filter membrane 6 which is folded are housed in the bottom part 3. The membrane is compressed at the periphery with the inner lid 7 - rectangular. This inner lid is tightened at its edge flange 7' with fixing screws 8. The upper edge of the inner lid 7■ is closed by screwing a screw 9, and the inside of the inner lid 7 forms a 'd'dW of the filtrate. 10 is the pressure droplet, 11 is the pressure pressure droplet for filtration removal, and 12 is the pressure droplet for sealing. These members are designed to withstand the readings applied for ultrafiltration. Withstand pressure of m2 or more! Figure 3 shows the details of the bottom of the valley where rl: is made. Overall, the cross section is H-shaped (V) The bottom part 3 has a male screw 31 with a fixing screw on the upper inner surface, and a V-shaped trace of an IW temple 32 of f'i magazine on the bottom surface. In addition, Chiang 33 has a narrow O-ring 12θ
Most of the ring 12 is immersed in this ring string 33, and the clamp attached with the fixing screw 8 is attached to the bottom of the support plate 5 and remains below this support plate. trade
.

Minimize the amount of phlegm liquid required.

On the inner periphery of the lower surface is a drawing adapter 2 for later reading, and a female thread 34 for the throat attachment, and in the center - an injection needle for pouring liquid into a vial] 3. A male luer slip 4 is provided to match the luer slip.

As shown in a perspective view and a three-sided view in Figure 4, the adapter 2 is composed of a vial holder 15 that stores and holds a vial 14, and a movable part 16 that is movably engaged with the vial holder 15. At the top of the movable part 16 is a screw 16 that matches the Q screw 34 of the answering section.
1 is provided, and the position of the shear adapter 2 with respect to the filtration valley 1 is determined by this screw 161 k 1) ALE. Bottle 9f, holding 8I515 has a vial bottle 140 at the bottom.
The lower part meets the beast, and its inner surface is movable 16.
1. Further, if necessary, the window 152 may be closed until the bottle 14 is visually maintained.

This lotus pass! The device is used as follows.

As shown in the conceptual diagram of FIG. 5, this extralingual overload f is fixed to the machine frame (not shown) with a fixing fitting 18. Next, the feeder inlet 10Fi automatic g H1 device and check valve 19
It can be heated with one touch by using a luage joint through a Teflon tape cove. Also 7111 pressure gas introduction port 1
1 is connected via a pressurized gas control valve 20 and a Teflon tube.

Position fkP: The vial bottle 14-karat gold Nobujin is attached to the female adapter 16 from the upper part of the mounting screw 161, and the mounting screw 16 is attached to the female adapter 16 with the adapter housing moving part 16 pulled upward (Fig. 6a).
1 on the lower surface O of the threaded section 3, the bottle 14 in the bottle holding section 15 and the luer slip male 4 are attached.
The relative position with respect to the injection needle 13 that has been sewn is determined.

Next, by sliding the bottle holder 15 in the direction of the arrow in FIG. 6a, the injection needle 13 is attached to the vial 14)
The injection needle 13!7) is re-extended to the center of the image 41v, and the tip of the injection needle 13!7) is correctly positioned above the source of the photoelectric detection hQ. 23 is an air vent needle.

Figure 5 conceptually shows the 21Fi system (goods) panel f
, Thsu, Rehlo te, 4. ocal fi
'j J Kaisui 7 f Th, LocalVi shows the remote 1 movement based on No. 16 from the German-Japanese drive and the Remo Leij song Q machine finger with this device. Loc
In the al mode, filtration is started by the 1-un switch. T1 to T6 are timers, and T, ~, which will be described later, are timers.
When T4 is set, @ is set, the feature shown in Figure 7)'f:&, and the Run switch is turned on (
The dazzling H■ transfer is started by the Remote Tokine et al. To prevent malfunction 1
Wait 1 second, activate the halo detection 622, and when the time interval becomes 12 or more, it is determined that the transfer is complete, and the pressurized gas is discharged from the tank volume 11 to the tank volume 1. person, g
A check valve 19 prevents the 0 pressurizing force from entering the 0-pressure-pressing system, which starts the flow. Start passing through you, a! 4. If you hunt for 13 seconds to prevent movement, move the former Arashi Danshi b17 to r[ and display the time interval of the slave's subordinate. When this interval reaches a preset time of 11 seconds or more, it is cut off as U-Excess and an end signal is sent.0 (Effects of the Invention) This invention has the above-mentioned configuration, and has the following remarkable effects. has.

■ If a sterilized rapid container is used, the sample can be filtered without coming into contact with air or bubbles until it is stored in a vial.

■ By constantly monitoring the condition of the subordinates and determining that the treatment is over if the dripping time is longer than a certain time, the time required for filtration can be kept to a minimum, and this method is especially effective when processing short-lived Kinutokusode-labeled compounds. are doing.

■ The positioning adapter makes it extremely easy to insert the injection needle into the instant position of the vial, making it very easy to monitor the filtration status.

■ All operations are automated and remote production is possible, allowing safe handling of radioactive materials.

■ This filtration device is particularly suitable as an ultrafiltration device for adjusting the filtration in hospitals, etc., but ■〜■
The young fruits are not limited to this purpose in particular, and have a wide range of applications as filter devices.

(9)

[Brief explanation of drawings]

Figure 1 is a cross-sectional view of one part of the filtration device of this invention.
Figure 2 is a perspective view of the filtration container 11#, Figure 3 is a detailed view of the bottom of the filtration container, and Figure 4 is a perspective view of the adapter V and 3if1.
Fig. 5 is a conceptual diagram of the filtration device and cape f&f7), Fig. 6 is a direct cut diagram of the operation of the adapter, and Fig. 7 is a flowchart of the operator of the filtration device. 1: Various lines 2: Several lines of the bottle 3: dIg lower part 5: Filter membrane support plate 6: Thin membrane 7: Inner lid 8: Fixing screw
9: Top lid 10: Obesity 11: 7J11 special force 12; 0 ring 13: Syringe needle 14: Vial 15: Bottle holding part 16: Movable part 17.22: yt
, 凰11d18: Fixed gold eight 19: Check valve 20: Pressurized pressure smooth double valve 21: Control cape panel 23: Percentage needle Applicant: Science and Technology Agency, Medical Research Institute (l tlJ Somiwa 271

Claims (1)

[Claims] It has a built-in membrane, a filtration container into which the sample is introduced, a container for storing liquid, and a positioning adapter that is fixed at a certain position on the filtration container, and the filtrate outlet of the filtration container is connected to the injection needle area. A filtration device, wherein the adapter has a non-contact opening for detecting dripping of filtrate, and each container holder that can slide against the attachment part to the filtration container has a non-contact opening for detecting dripping of filtrate.