JPS60193928A - Nutritive composition through tube - Google Patents

Abstract

PURPOSE:The titled composition useful for nutrition supply for a patient before or after operation, obtained by blending protein, glucide, lipid, vitamin and mineral as main components with a specific amount based on the solid components of polyglycerin fatty acid ester. CONSTITUTION:A composition comprising 10-40wt% (wt% based on solid content of nutritive compound) protein or its hydrolyzate (easily digestible, high nutritive value; egg protein, soybean protein, etc.), 50-80wt% glucide (e.g., starch, dextrin, etc.), 5-35wt% lipid (e.g., fatty acid such as linoleic acid, etc., soybean oil, etc.), vitamin and mineral as main components is blended with 0.1- 10wt% polyglycerin fatty acid ester, an ester between a polyglycerin having 3- 10 polymerization degree and a fatty acid, and a number of ester bonds of 1- 10, as an emulsifying agent, to give a nutritive composition through tube having improved emulsion stability of lipid component, good digestion and good absorption.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a tube feeding composition used for nutritional support to patients before and after surgery.

Methods for patient nutrition include enteral nutrition (oral nutrition compositions, tube nutrition compositions) and enteral nutrition (parenteral nutrition compositions).
There are two methods. In most cases of enteral nutrition, tube feeding compositions are used.Tube feeding compositions: ■ have well-balanced nutritional components and are high in calories, and ■ are easily digested and absorbed. It is required to not cause diarrhea or abdominal bloating, and (1) to have good emulsion stability and good tube flowability.

Currently, various tube feeding compositions are commercially available, but no product has yet been found that fully satisfies the above requirements.

In tube feeding compositions, fat is a calorie nutrient source that has about twice as many calories as carbohydrates and proteins;
Supplying essential fatty acids such as linoleic acid and lylunic acid,
It has important functions such as being a source of fat-soluble vitamins.

Although lipids have such important nutritional functions, there are several problems with conventional products used for nutritional supplementation. It has been pointed out that it is not included.

The above problems are mainly caused by the difficulty in properly emulsifying lipids, and poor emulsification of lipids in tube feeding compositions can cause diarrhea and a decrease in cheese fluidity. This is because it is not possible to add a sufficient amount of lipid.

As a result of extensive research into these problems, the present inventors have found that certain polyglycerides have excellent osmotic pressure-lowering effects as emulsifiers, have no clinical side effects such as diarrhea and abdominal bloating, and are nutritionally superior. In tube feeding compositions containing carbohydrates, lipids, vitamins, and minerals as main components, which are superior to conventional products, polymerized polyglycerin fatty acid ester is used as an emulsifier to reduce the solid content (all components other than water). ), the tube feeding composition is characterized in that it contains 0.1 to 10% by weight.

The polyglycerin fatty acid used in the present invention includes esteronic acid, oleic acid, lauric acid, linoleic acid, etc. Those using linoleic acid can be effectively used as a nutritional component since linoleic acid is an essential fatty acid. Examples of polyglycerol fatty acid esters include tetraglycerol pentaoleate and hexaglycerol monostearate.

Hexaglycerin sesquistearate, Dekaguri.

Polyglycerin fatty acid esters may be used singly or in combination of two or more. Preferably, it is appropriate to use a combination of water-soluble and oil-soluble ones.

The amount of polyglycerin fatty acid ester to be used should be 01 to 10% by weight relative to the solid content of the nutritional composition, and if it is less than 01%, the emulsifying function cannot be exhibited, and
Since its function is fully exhibited within the range of weight, it is not necessary to add more than 10 weight.

The present invention relates to a tube-feeding composition that can sufficiently supply nutrients necessary for the human body, and whose main components are proteins or decomposition products thereof, carbohydrates, lipids, vitamins, and minerals.

The protein or decomposition product thereof used in the present invention is one that is easily digestible and highly nutritious. Enzymatic decomposition products of Tore et al. are used. In addition, various amino acids and peptides prepared based on nutritional design are used. The amount used is approximately 10 to 40% by weight based on the solid content (hereinafter, all components other than water) of the nutritional composition.

The carbohydrates used in the present invention include starch, dextrin, and hydrolyzates thereof. It can also be used with monosaccharides such as glucose and fructose, and trisaccharides such as maltose and lactose. This usage amount is 50% based on the solid content of the nutritional composition.
It is about 80% by weight.

The lipids used in the present invention include fatty acids such as linoleic acid and lylunic acid, soybean oil, corn oil, and rapeseed oil.

Animal and vegetable oils such as coconut oil, lard, beef tallow, and fish oil.

Processed fats and oils such as medium-chain fatty acid triglyceride and linoleic acid triglyceride. They can also be used in effective combination. The amount used is about 5 to 3'5% by weight based on the solid content of the nutritional composition.

Minerals and vitamins, which are trace components, may be derived from the above-mentioned raw materials, but nutritionally necessary minerals and pitamines may be added as appropriate. Also, if necessary, known emulsifiers such as lecithin, salts such as phosphates, citrates, and fruit juice.

Flavors may also be added.

The tube feeding composition of the present invention is formulated with a predetermined amount of protein or its decomposition products, carbohydrates, lipids, vitamins and minerals, emulsifiers, water, etc., stirred, sterilized, and then homogenized using a homogenizer. , it can be commercialized as a uniform liquid product. It is preferable to use various conventional sterilizers and sterilizers for sterilization and sterilization. The product can also be dried into a powder, such as by spray drying. When using powdered products, dissolve them in water or hot water to reduce the solid content to 5-40%.
, usually at a concentration of about 20-25%.

□ The tube feeding composition of the present invention contains essential fatty acids that are not found in conventional products due to the combination of a special emulsifier.

It has many advantages over similar tube feeding compositions, such as being able to incorporate fats and oils, has good digestion and absorption, and can extremely reduce diarrhea and abdominal bloating. It is something.

(1) Emulsion stability of lipid components: The solution has excellent tube fluidity, making it easy to blend the required amount of lipid components, and eliminating essential fatty acid deficiency diseases.

(2) Emulsion stability: The size of the lipid particles is small, allowing digestion,
It is well absorbed and does not cause diarrhea.

Good digestion and absorption. It is also possible to add super acidic flavors, making it easier to drink if oral administration is possible.

Dissolve 5 in 9 in water and add 30 J' of hexaglycerin sesquistearate (equivalent to 0.3 qb), 1 to 9 in this solution.
of sodium caseinate, 500 J' of soy protein, 6
．． 6Kg of dextrin was dissolved. On the other hand, oil containing 1 part soybean oil and 500 parts medium chain fatty acid triglyceride, and 100 parts tetraglycerin pentaoleny)
(equivalent to 1.0%), mixed this blended lipid with the above aqueous solution, and further mixed with about 228 vitamins and minerals shown in Table 1 (solid content: 10 equivalents). The mixture was pre-emulsified using a stirrer. This emulsion was treated with an ultra-high temperature instant heat sterilizer at 140°C for 4 seconds, then homogenized aseptically at 70°C with a homogeneous pressure of 150 kg/'c+1, cooled to 20°C, and placed in a sterile container. The mixture was sterilized and a tube-prepared composition was obtained.

Table 2 shows the nutritional composition of this product based on the solid content of 100P. The energy of this solution is I KcILt/m1
It is. When this composition was left at room temperature for 6 months, syneresis occurred.
No oil separation was observed, and the emulsion stability was good.

Table 2 Nutrient composition (solid content 100/hit) Example 2
．． In Example 1, 15Y was used instead of 34.5)+ water.
The same raw materials as in Example 1 were used except that water from Step 4 was used, and the mixture was dissolved according to Example 1 and emulsified using a homogenizer.

After sterilizing and homogenizing this emulsion, it was spray-dried to give a
A powder product of 9 was obtained. The vitamins and minerals were each weighed as shown in Table 1 and blended with the powder product by powder-to-powder mixing. This powder product had the nutrient composition shown in Table 2, and was diluted with warm water to form a 224% aqueous solution, which could be used as a tube feeding composition in the same manner as in Example 1.

Examples 3 to 7 and Comparative Examples 1 and 2 Tube feeding compositions were obtained in the same manner as in Example 2 using the polyglycerin fatty acid esters and other emulsifiers shown in Table 3.

〔performance test〕

Examples 1 to 7 and Comparative Examples 1 and 2, Saranyo commercial products A and B
Performance tests were conducted on the emulsion stability and tube fluidity of the product using the following methods, and the results are shown in Table 3.

From the results in Table 3, it is clear that the examples using the polyglycerol fatty acid ester of the present invention have extremely excellent emulsion stability and tube fluidity.

An administration test was conducted on 5 patients after surgery.

Table 4 shows the clinical course during administration for 7 to 49 days.

From the results in Table 4, it is clear that no diarrhea or abdominal bloating was observed in any of the patients, and good results were obtained for other clinical test items. other,
A similar clinical experiment was conducted on 35 patients, and there were no side effects and good nutritional management was achieved. From the above results, it was confirmed that the tube feeding composition of the present invention caused no side effects when administered and was nutritionally excellent.

Example 8 20. P sodium citrate at 343 K
Dissolve 9 in water, add 15 J' of decaglycerin monostearate (equivalent to 0.15%), 1.5 to 9 sodium caseinate, IKg of whole egg enzymatic decomposition product, 4.2 to 9. Dextrin, 2~ dissolved maltose. Meanwhile, IK9175 corn oil has 20. Dissolve the lecithin of P.
This oil was mixed with the above aqueous solution and pre-emulsified. Further, weighed amounts of vitamins and minerals shown in Table 1 were dissolved in this emulsion, homogenized using a homogenizer, and filled into cans. This is 115°C1
Heat sterilization was performed for 30 minutes to obtain a liquid tube feeding composition. The nutritional composition of this product based on the solid content of 1001 is shown in Table 5.

The energy of this composition is I Kcal/mJ,
When this solution was left at room temperature for 6 months, no syneresis or oil separation was observed, and the emulsion stability was good.

Example 9 2.4 kg of dextrin, 7201 amino acid combination (Table 6 shows the blending ratio of various amino acids.)
801 minerals (formulation in Table 1), 24/' vitamins (formulation in Table 1) in 13.3 kg of 70
It was dissolved in a book warmed to °C. 320 J' of hexaglycerol monolyte (equivalent to 8 J') was dissolved in 480 P of linoleic acid, mixed with the above aqueous solution, and emulsified using a homogenizer. This emulsion has IKcal/+II
It could be used as a tube feeding composition.

This composition maintained emulsification over a long period of time and exhibited good emulsion stability.

Example 10 The formulation shown in Table 7 was dissolved in 3.4K9 warmed water and treated according to Example 9.
A tube feeding composition of Kcal/ml was obtained.

Example 11 In 2.76, dextrin 9 and 207' decaglycerin monolaurate were dissolved in water, and this solution was heated to 70°C. of linoleic acid and 2
40j medium chain fatty acid triglyceride was mixed and emulsified. This emulsion was sterilized and homogenized, and then spray-dried to obtain raw powder. This raw powder was powder-to-powder mixed according to the recipe shown in Table 8 to obtain a powder product of the tube feeding composition of Example 10. 4.5 times the amount of hot water was added to this powder product to dissolve it and it could be used as a tube feeding composition of I Kcal, /II+'.

Table 8 When this composition was left at room temperature for 24 hours, no syneresis or oil separation was observed, indicating good emulsion stability.

Claims (1)

[Scope of Claims] 1. In a tube feeding composition containing proteins or their decomposition products, carbohydrates, lipids, vitamins and minerals as main components, a fatty acid ester having a degree of polymerization of 3 to 10 is used as an emulsifier in solid form. A tube feeding composition characterized in that the composition contains 0.1 to 10% by weight per minute (all components outside the water plate). 2. At least the polyglycerin fatty acid ester is selected from tetra, glycerin pentaoleate, hexaglycerin monostearate, hexaglycerin sesquistearate, decaglycerin monostearate, decaglycerin monolaurate, and decaglycerin decaoleate. The tube feeding composition according to claim 1, which is one type.