JPS60163948A - Polypropylene resin composition - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to press-through packaging (hereinafter referred to as "ru") used for packaging pharmaceutical tablets, capsules, etc.

Conventionally, hard vinyl chloride resin sheets (hereinafter abbreviated as vinyl chloride sheets) have been mainly used for FTP packaging. However, the moisture permeability of PVC sheets is too high for pharmaceuticals that are susceptible to deterioration due to moisture, such as aspirin and antibiotics. Furthermore, they are used by laminating polyvinylidene chloride, etc., which have low moisture permeability, which makes them expensive. be. Therefore, there is a desire for a resin sheet suitable for FTP packaging that is cheaper and has lower moisture permeability.

On the other hand, polypropylene resin sheets have problems with transparency and thermoformability, even though their moisture permeability is lower than that of vinyl chloride sheets, and the reality is that they are hardly used in FTP packaging.

By the way, a method for improving the transparency of a polypropylene resin sheet is to add a nucleating agent such as dibenzylidene sorbitol to polypropylene resin, and a method for improving thermoformability is to add polyethylene resin to polypropylene resin. Blending methods are known, but each has advantages and disadvantages; for example, the former has poor moldability, and the latter has poor transparency, which poses problems for use in FTP packaging.

One way to simultaneously improve the transparency and thermoformability of a polypropylene resin sheet is to blend hydrogen petroleum resin with polypropylene resin, which is suitable for FTP packaging in terms of mechanical and optical properties. However, the sheet obtained by this method is made of normal heptane (hereinafter 1.
- Abbreviated as HT. ) The elution amount is large, and the Ministry of Health and Welfare Notification No. 2
The reality is that many of them do not meet the No. 0 standard (150 ppm or less) and are virtually unusable.

As a result of intensive studies to solve the above problems, the present inventors found that if a specific amount of fine silica powder is added to the above composition, the elution amount will be reduced, the standards of Ministry of Health and Welfare Notification No. 20 will be satisfied, and the composition will be transparent. The inventors have discovered that a sheet suitable for press-through packaging can be obtained that has good properties and mechanical properties, and has thus arrived at the present invention.

This is a polypropylene resin composition for press-through pack packaging.

In the present invention, as the polypropylene resin, homopolypropylene or a random copolymer of propylene and an α-olefin such as ethylene or butene-1 can be used. Among them, those with a melt flow index (hereinafter abbreviated as MI, unit: !9/10 minutes) measured under JIS I (7210 condition 14) of 1 to 4, and homopolypropylene with a good balance of transparency and moldability. It is preferable.

When 1v■ is less than 1, transparency deteriorates, and when MI exceeds 4, it becomes sticky during thermoforming, resulting in poor moldability.

The hydrogenated petroleum resins used in the present invention include hydrides of aromatic hydrocarbons, hydrides of terpene resins, etc., and specifically include styrene, α-methylstyrene, vinyltoluene, vinylxylene, propenylbenzene, inden ,
Hydrogenated resins obtained by polymerizing one or a mixture of two or more of various aromatic unsaturated hydrocarbons and/or terpenes such as methylindene and ethylindene, and decomposition and modification of petroleum. Boiling point 20-30 as a by-product during
Examples include hydrogenated resins obtained by polymerizing fractions at 0°C, particularly 150 to 600°C.

In the present invention, the amount of hydrogenated petroleum resin used is 3 to 20 parts by weight, preferably 6 to 11 parts by weight. If the amount used is less than 3 parts by weight, the effect of improving transparency and thermoformability will be insufficient, and if it is used in excess of 20 parts by weight, thermoformability will deteriorate.

The silica fine powder used in the present invention conforms to JIS Z8901
Those having an average particle diameter of 5 μm or less, preferably 1 μm or less as determined by the sedimentation method shown in (1) can be suitably used.

As the particle size of the fine silica powder increases, the smoothness of the sheet deteriorates. The amount of fine silica powder added is 0.05 to 1 part by weight, preferably 0.005 to 1 part by weight, per 100 parts by weight of polypropylene.
It is 1 to 0.5 parts by weight. Addition amount of silica fine powder is 00
If it is less than 5 parts by weight, the hydrogenated petroleum resin will have an insufficient elution suppressing effect on HT, and if it exceeds 1 part by weight, the transparency of the sheet will be impaired.

The polypropylene composition of the present invention is produced by blending polypropylene, hydrogenated petroleum resin, and fine silica powder together with a stabilizer for polypropylene in a known device such as a Henschel mixer, and then pelletizing it in a known device such as an extruder. . After that, it is extruded from a T-die, for example, to form an FTP packaging sheet.

The FTP packaging sheet obtained in this way has excellent moisture permeability, transparency, and safety, and is also excellent in thermoformability during FTP packaging, and can be put into practical use by being put into a molding machine for FTP packaging. It will be done.

FTP packaging is a form of packaging in which tablets, capsules, etc. are packaged with a plastic sheet pocket and aluminum foil that seals the pocket. Usually, a thermoplastic sheet is thermoformed, and elixirs, capsules, etc. are automatically packaged into this. The process is carried out using a high-speed automatic packaging machine that continuously performs the steps of filling, sealing with aluminum foil, making perforations and slits, and punching out the outer periphery.

The FTP packaging sheet obtained from the polypropylene composition of the present invention has excellent formability during thermoforming, and also has good thermal adhesion with aluminum foil and punching properties, so it has less uneven thickness. Excellent FTP packaged products can be obtained at high speed. Furthermore, the quality of the FTP packaged product obtained is excellent in terms of transparency, moisture permeability, and safety.

The present invention will be further explained below with reference to Examples.

Examples 1 to 6 and Comparative Examples 1 to 4 IVII= containing 1 part by weight of ditertiarybutyl-p-cresol and 0.1 part by weight of calcium stearate
To 100 parts by weight of homopolypropylene No. 2, hydrogenated petroleum resin with the softening point shown in Table 1 was added in the amount shown in Table 1, and the average particle size was 1 μm.
Synthetic silica (manufactured by Fuji Davison) was blended in the amount shown in Table 1, mixed in a Henschel mixer, and then extruded at 240°C using an extruder with a cylinder diameter of 40 mm to obtain a pellet.

This pellet was heated to 240℃ using a cylinder with a diameter of 4 with a T-die.
Formed into a sheet using a Qmm extruder, 11200mm,
A PTP packaging sheet with a thickness of 0.25 tn and m was obtained.

Next, this sheet is transferred to an FTP packaging machine M manufactured by Kanae Co., Ltd.
FTP packaging was performed using 2O00 to evaluate moldability. Further, the transparency, moisture permeability, and -HT elution amount of this sheet were also measured. The results are shown in Table-1.

Transparency was determined by measuring haze according to ASTM-D-'I D 03, moisture permeability was measured according to ASTM-E-96, and n-HT elution amount was determined according to Ministry of Health and Welfare Notification No. 20.

Claims (1)

[Claims] 1. A polypropylene resin composition for press-through pack packaging, which contains 3 to 20 parts by weight of hydrogenated petroleum resin and 0.05 to 1 part by weight of fine silica powder per 100 parts by weight of polypropylene resin.