JPS5839615A - Dentrifrice composition - Google Patents

Abstract

PURPOSE:To provide a dentrifrice composition effective for the prevention of oral odor and periodontosis, by using extract of Amur cork, clove, blue gum, mace, celery and/or parsley in combination with sodium alkylsulfate. CONSTITUTION:A dentrifrice composition is obtained by adding (A) the extract of a plant selected from Amur cork, clove, blue gum, mace, celery and parsley and (B) preferably 8-18C alkylsulfuric acid sodium salt, e.g. sodium caprylsulfate, especially sodium laurylsulfate, to a dentrifrice composition such as toothpaste, moistened tooth powder, tooth powder, liquid dentrifrice, etc. The amounts of the components (A) and (B) are preferably 0.0005-5wt%, especially 0.002- 2wt%, and preferably 0.1-5wt%, especially 0.5-3wt% of the whole composition, respectively. The above components exhibit excellent synergistic antibacterial effect even at a small amount against Fusobacterium nucleatum which is a pathogenic bacterium of oral odor and periodontosis, and gives the objective dentrifrice composition having high safety.

Description

[Detailed Description of the Invention] The present invention provides yellowfin tuna, clove tuna, 21 ka'Je/-x
The present invention relates to a toothpaste composition that exhibits good antibacterial activity against Zopacterium nucleatum by using an extract of a plant selected from e-celery and Japanese parsley together with sodium alkyl sulfate.

There are various types of bacteria in the oral cavity.
t@r1day nagl@atum)? 1 Indole hydrogen sulfide and Mercagatum nucleatum are attracting attention as one of the causative bacteria of bad breath and periodontal disease. - Suppressing the growth of Fusibacterium nucleatum is effective in preventing bad breath and periodontal disease.

In the past, sodium alkyl sulfates have been recognized to have surfactant properties and antibacterial properties against bacteria such as Staphylococcus aureus, but their antibacterial properties against Fushi/4 Acterium nucleatum are not high as shown in the experimental examples described below. .

In view of the above circumstances, the present inventors have conducted intensive research on active ingredients for toothpaste that have a high antibacterial effect against Fusibacterium nucleatum.

We screened various plants as natural additives, including yellowfin, clove, eucalyptus, and mace.

As a result of selecting extracts of celery and/or mother celery and using one or more of these in combination with sodium alkyl 1 mold, these were found to be specifically superior to Zopacterium nucleatum even in small amounts. It synergistically exerts antibacterial action.
Jum and is placed in the toothpaste composition.

The present invention was made based on the discovery that the combination of the two is effective in preventing bad breath and periodontal disease.

The present invention will be explained in detail below.

The present invention uses yellowfin tuna, clove, and eucalyptus in dentifrice compositions such as toothpaste, moistened dentifrice, powdered dentifrice, and liquid dentifrice.

It is a blend of one or more plant extracts selected from mace, celery, and Japanese parsley, and an alkyl sulfate.

In this case, the raw materials used to obtain the extract of the plant include powders of the plants; residues obtained by extracting oil from these plants by steam distillation and other essential oil extraction residues; Oleoresin and its extraction residue obtained by extraction with lower alcohols such as dioxane, acetone, ethanol, and methanol, and polar solvents such as ethyl acetate, propylene dalicol, glycerin, and water; n-hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane% 1.2-
The oleoresin obtained by extraction with a nonpolar solvent such as dichloroethane, toluene, or benzene, and the extraction residue thereof are used. When obtaining an extract of the plant from these raw materials, one or more polar solvents and/or non-polar solvents of these raw materials (the solvents listed above are used) The extract (extract liquid or extract from which the solvent has been distilled off) is collected. In the present invention, this extract can be used as it is, but it is also possible to use a steam distillation residue obtained by steam distilling this extract, or a steam distillation residue obtained by steam distilling this extract, or a steam distillation residue such as activated carbon, diatomaceous earth, acid clay, etc. Plants treated with an adsorbent, as well as residues obtained by steam distillation after treating the extract with an adsorbent, can also be suitably used as the plant extract. In addition, as an extraction method, a known method can be adopted. For example, a method such as digesting the dried powder of the above plant in a solvent can be adopted. In this case, an organic solvent is preferable as the solvent, and the above plant is soaked in an organic solvent. The specific solvent extract obtained by extraction with Ks? is more effective. If so, these solvent extracts (single plant extract, mixed plant extract) may be used alone or in combination of two or more.

In addition, the amount of these plant extracts added to toothpaste compositions is as follows:
0.0005 sounds (heavy vomit, same below) to 5% of the total,
It is preferable that the kernel has a qlK of 0.002 to 2.

The alkyl and sodium sulfate used in the present invention preferably have an alkyl group with a carbon number of 8 to 18, such as sodium caprylic sulfate, sodium lauryl sulfate,
Examples include sodium chloride sulfate and sodium chloride sulfate, but sodium lauryl sulfate is particularly preferred.In addition, the amount added to the toothpaste composition is 0.1 to 5 ml of the total amount, and 0.5 to 3 ml of 4IK. − is desirable.

As other components of the present invention, appropriate components are used depending on the type of toothpaste composition.For example, in the case of toothpaste, #
i, dibasic calcium phosphate dihydrate and anhydride, calcium carbonate, -calcium rophosphate, calcium sulfate,
Abrasives such as insoluble sodium metaphosphate, amorphous silica, crystalline silica, aluminosilicate, aluminum hydroxide, aluminum oxide, resin, etc.
60%), binders (0.3-59
1) Thickening agents (10 to 7 ou
), and if necessary, in addition to sodium alkyl sulfate, sodium dodecylbenzenesulfonate, hydrogenated sodium trauryl sulfoacetate, and N-lauroyl dercosinic acid. Sodium, N-acylglutamate, laurylgetanolamide, Shida sugar fat.

Foaming agents (θ ~ 596) such as fatty acids and esters are blended.Additionally, % (Δ-bento, essential oils such as spearmint, fragrance materials such as t-menthol, carmine, eugenol, anethole, etc.) It is produced by mixing ingredients such as sweeteners and preservatives such as satucarin sodium, -tevioside 1, neohesberidyl dihydrochalcone, glycyrrhizin, irilartin, p-methoxycinnaqualdehyde, and thaumatin with water, and according to a conventional method.

In addition, in the present invention, in addition to the above-mentioned plant extracts, lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexidine or seven salts, sorbic acid, alexidine, hinokitiol, cetylpyridinium chloride, alkylglycine, alkylsia t Noethylglycine salt, 7 lantoin, 8-7 minocaprone amount, tranexamic acid, azulene, vitamin E1 monofluoroline sodium, sodium fluoride, stannous fluoride, water-soluble mono- or di-phosphate, quaternary Active ingredients such as grade ammonium compounds and sodium chloride can also be blended.

Accordingly, the toothpaste composition company, Ki/Nda, related to the present invention.

By using extracts of clove, eucalyptus, mace, celery, and Japanese parsley together with sodium alkyl sulfate,
They act synergistically to exert an excellent antibacterial effect against Zopacterium nucleatum, and are therefore effective in preventing bad breath and periodontal disease caused by this bacterium.

In addition, the toothpaste composition of the present invention contains highly safe plant extracts as active ingredients, and these extracts are highly effective even at relatively low concentrations, so the amount of these extracts can be reduced. It is therefore highly safe to use.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

[Experiment example]

Add 300 d of the required solvent to 100.0 g of dry powder of the plants shown in Table 1, and add 300 d of the required solvent. The mixture was refluxed for 1 hour on a water bath at 00°C with a cooling tube attached.Then, the solvent fraction was separated in a furnace, fresh solvent was added to the residue, and the same reflux was repeated twice, making a total of 3 extraction operations. Nine.

The solvent extracts were combined and concentrated under reduced pressure to obtain extracts of various plants.

Table 1 shows the extraction results for each plant.

Table 1: Next, a medium containing 0.001% of sodium alkyl sulfate, a medium containing 0.01 of each plant extract, a medium containing 0.0O1% of sodium alkyl sulfate, and extracts o and oi* of each plant. 1/100 amount of Fucibacterium nucleatum 1436, which had been precultured once, was added to the medium.

Under anaerobic conditions <so fight N2.1osa2. ．． 2ojco□
) and cultured at 37° C. for 2 days.Then, the degree of bacterial growth was measured by absorbance at 550 nm. Second result
! I! Shown below.

The medium used was Todd Hay's medium (manufactured by DIFCO) containing 0.05% cysteine.

From the results in Table 2, it is clear that when extracts of yellowfin tuna, clove, eucalyptus, mace, celery, and /f Japanese parsley are used together with sodium alkyl sulfate, these act synergistically on 7zopacterium nucleatum, and 7zo/4 It is found that it exhibits excellent antibacterial activity against C. nucleatum.

Examples are shown below.

[Example 1] Toothpaste dicalcium phosphate dihydrate, 50% glycerin 20 Calgoxymethylcellulose 1.0 fragrance
Materials 1.0 ζ Sodium listyl sulfate 1.0 Celery methanol extract 0.05 Yellowfin tuna 80% ethanol extract 0.05 Saccharin 0.1 Sodium fluoride 0.1 Allantoin
0.1 water
1G0 left. OS [Example 2] Toothpaste dicalcium phosphate dihydrate 50 Sorbitol 10 Glycerin 10 Carxymethylcellulose 1.0 Fragrance
Materials 1.0 Sodium lauryl sulfate 1.0 Ethyl celery acetate extract 0.1 Sodium monofluorophosphate 0.3 Ethanol 2
．． 0 Satucalin 0.11 Mutanase 0.11oo, o* [Example 3] Toothpaste calcium carbonate 50 Chronic glycerin
20 Kara r Nan 0.5 Cal xymethylcellulose 1.0 Sugar monolaurate 2.0 Flavoring 0.8
Sodium thilauryl sulfate 1.0 Eucalyptus methanol-n-hexane (1:1) extract
0.1 Chiyoji ethanol extract 0.05
Satucalin 0.1 Chlorhexidine hydrochloride 0.005 Dextranase 0.01 Azusin
0.1 water
Remaining ioo, o H: Example 4 Toothpaste dicalcium phosphate dihydrate 50 -
Glycerin 20 Cal? oxymethylcellulose 2.0
Fragrance, 1.
0 Sodium lauryl sulfate 2.0 Mase methanol extract 0.1 Chlorhexicine gluconate 0. Ol saccharin
0.1 glycyrrhizic acid
0.2 Bentonite 0
．． 5 91 [Example 5] Toothpaste anhydrous silicon W1 30 Tatami glycerin 30 Sorbitsu 20 Sozoum lauryl sal 7ate 2.0 Calgaxymethylcellulose 1.0 Fragrance
Materials 1.0 Saccharin 0.1 Sodium lauryl sulfate 2.0 Parsley methanol-n
-hekisan (1:1 blade extract 0.1 tranexamic acid 0.1 [Example 6] Liquid toothpaste glycerin 35.0% Color r naan 165 Katsu! Ring sugar 2.0 Fragrance
0.9% ethanol
1.0 Sodium monofluorophosphate
0.5 Sodium lauryl sulfate
1.5 Chiyoji 75 ethanol extract
0.1 celery + yellowfin tuna water extract
0.1 Chlorhexidine hydrochloride 0.0
1 [Example 7] Powder toothpaste dicalcium phosphate dihydrate 50.0
% Calcium carbonate 30.0 Glycerin 10.0 Flavor
1.0 Satukarin
0.1 Sodium monofluorophosphate
0.1 Sodium lauryl sulfate
1.0 Eucalyptus methanol extract 0.
301 Ethanol extract of 1 stew 0.1 Dextran 0.51υ0. υ cost

Claims (1)

[Claims] Yellowfin tuna, clove, nikari, mace, celery and/l
4. A toothpaste composition characterized by containing one or more plant extracts selected from Japanese parsley and sodium alkyl sulfate.