JPS5820280B2 - Method for producing amylodextrin fine granules - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for producing amylovkis l-IJ fine granules.

In the present invention, amylodextrin has a molecular weight of about 10,000 to about 1
00,000 dextrin.

Amylodextrin is widely used in the food industry, pharmaceutical industry, etc.

Amylodextrin is a bluish-blue powder that is poorly soluble in cold water when reacted with iodine starch, and has scattering properties, adhesion and agglomeration properties, and no fluidity.

In addition, it has the property of being extremely dispersible and difficult to wet with water, and when poured into water, only the surface becomes wet and forms lumps, so-called lumps, which are difficult to dissolve.

The present invention relates to a method for simply and easily converting amylodextrin powder having the above-mentioned properties into fine amylodextrin particles having good fluidity and good dispersibility and solubility in water.

Various methods of granulating dextrin have been known in the past (for example, Japanese Patent Publication No. 36-2,164, Japanese Patent Publication No. 5
No. 0-26,512), no satisfactory method for producing amylodextrin fine particles is known.

Dextrin is a general term for various degradable products that hydrolyze starch to maltose, and its types include limit dextrin, Schalzinger dextrin,
Examples include soluble starch, thin starch, amylodextrin, white dextrin, yellow dextrin, British gum, erythrodextrin, acrodextrin, and pharmacopoeia dextrin.

These dex I-IJ differ from each other in their properties, particularly in their solubility in water.

In the conventional method, it is unclear which of these dextrins is targeted.

Therefore, the present inventor attempted to produce fine amylodextrin particles by rolling, extrusion molding, kneading, and compression molding, and by agglomeration, but in all cases, lumps and uneven grains and powder were produced. Only a mixture was obtained.

In the case of the tablet manufacturing method, the tablets were obtained, but during sieving, they turned back to powder.

The present invention is a method of producing amylodextrin fine granules by spraying an alcohol solution to amylodextrin powder and then spraying water using a fluidized bed granulator. 25~ of the amount of raw material powder as
The amount is 35% (W/W).

The method of adding an alcohol solution and water during granulation is described in Japanese Patent Publication No. 15,722/1982.
In this method, the target material for granulation is one that is easily soluble in water, but has extremely low solubility in alcohol.
It has different properties from amylodextrin.

The present inventor followed the method described in the above publication (Example 1),
Attempts were made to produce fine amylodextrin granules using a Quick Kneader 1 universal mixer and a Sigma-type kneader as mixers, but in both cases, the mixture was not granulated and remained in the form of powder.

The same was true when mixing using a fluidized bed granulator.

Furthermore, when alcohol was added and mixed in advance using the above-mentioned mixer and fluidized bed granulator, and then water was added, no granulation occurred at all.

Granulation in the present invention is limited to dextrins having a molecular weight of about 10,000 to about 100,000, and other dextrins are not granulated.

Granulation in the present invention is achieved by setting a fluidized bed granulator to general granulation conditions, and is not particularly influenced by conditions such as air pressure, nozzle orifice diameter, or temperature.

The alcohol used in the present invention has a water content of 0 to 30% (
V/V) alcohol is sufficient, usually having 1 to 3 carbon atoms.
lower alkyl alcohol is used.

When the water content exceeds 30%, the amount of lumps gradually increases, and
When the temperature is 0, the sticky amylovkis l-1,1 begins to adhere to the inner wall of the granulator.

The amount of water used in the present invention is 25 to 25% of the amount of raw material powder as a whole.
The amount is 35% (W/W).

When hydrous alcohol is used in advance, the amount of water added is then reduced as necessary.

When the ratio is less than 25%, granulation is complete, and when f,

If the content exceeds 35%, the amount of lumps gradually increases, and if the content exceeds 40%, the amylodextrin becomes sticky and adheres to the inner wall of the granulator.

The amount of spray added is 150 for both alcohol solution and water.
~200 m1/min is preferable.

To increase the particle size, the diameter of the orifice may be increased when water is sprayed, the amount of water sprayed may be increased, or water in which Amylobucus I-IJ is dissolved may be used.

When the alcohol solution and water were spray added according to the method of the present invention using a granulator other than a fluidized bed granulator, a mixture of lumps and powder was produced.

When using a fluidized bed granulator and adding only a 0-30% hydroalcoholic solution, no amylodextrin fine particles were produced, and 25-30% amylodextrin fine particles were not produced at all, and the amount
When only 3s% (W/W) amount of water was added, lumps,
A mixture of grains and powder was produced, and when a mixture of alcohol and water in an amount of 25 to 35 ratios (W/W) to the amount of raw material powder was added, no fine grains were produced.

The chemical properties of the amylodextrin granules produced according to the present invention were not different from those of the amylodextrin powder, while their physical properties were greatly improved as shown in Table 1.

Example 1 Amylodextrin [Akatama Dextrin-WN (trade name, manufactured by Nippon Deka Chemical Co., Ltd.)] powder (5 kg) was charged into a fluidized bed granulator (GLATT-Convex KAWARA-WSG-5 model) at room temperature, and the working air pressure was 5 kg. /ffl, nozzle orifice diameter set to 1.8 mm, spray air pressure 3 kg/Cr1
95% isopropyl alcohol at 1. After the spraying was completed, 1.64 g of water was added by spraying at the same air pressure and the same orifice diameter.

When 0.61 was added by spraying, particles began to form, and when spraying was continued, most of the particles became fine particles.

After spraying, dry with air for 5 minutes at room temperature, and then dry for 30 minutes at an intake air temperature of 80°C and a temperature-controlled air pressure of 0.8 kg/cyit to obtain amylovkis l-IJ fine granules with a water content of 2 to 3. Ta.

Particle size 104~'500μ, yield 95%.

Table 2 shows the particle size distribution of the obtained fine particles.

Example 2 Amylodextrin [Akatama dextrin-NO-3D (
(trade name, manufactured by Nippon Deka Chemical Co., Ltd.)] 5.0 kg of powder was charged at room temperature into a fluidized bed granulator similar to that used in Example 1, and the operating air pressure was 5 kg/cyyt and the orifice diameter of the nozzle was 1.0 kg.
Set to 8mm and spray air pressure 4kg/crit to 80
1.01 g of methyl alcohol was added by spraying, and after the spraying was completed, 1.51 g of water was added by spraying at the same air pressure and the same orifice diameter.

When 0.61 was added, particles started to form, and when spraying was continued, most of the particles became particles.

After spraying, dry with air at room temperature, then reduce the intake air temperature to 60℃.
, moisture content is 2 when dried at temperature controlled air pressure 0.6 kg/crA.
-3 amylodextrin fine granules were obtained.

Claims (1)

[Claims] 1 Using a fluidized bed granulator, an alcohol solution is sprayed to the amylodextrin powder, and then water is sprayed, and the total amount of water sprayed is 25 to 35% (W /W) A method for producing fine amylodextrin particles.