JPS5817722B2 - Method for producing water-soluble pesticides - Google Patents

Description

Detailed Description of the Invention The carrier in the present invention is Na2SO4.10H2010
A water-soluble inorganic salt that has crystal water selected from H2O.7H20 or Na2CO3.10H20, from which 5 to 95% of the crystal water it possesses has been removed by heat treatment, or Na2SO4.10H20. Mix MgSO4・7H20 or Na2CO3・10H20 with their corresponding anhydrous salts to form Na2SO4・10H20, Mg
The requirement is to use SO4-7H20 or Na2CO3.10H20 in which the crystal water content of the entire mixture is adjusted to 5 to 95% as a carrier.

The dry removal rate of water of crystallization referred to in the following examples indicates the value from the above carrier.

According to the present invention, as shown in Examples (■ to A sex pesticide was obtained.

When using agrochemical active ingredients that are susceptible to hydrolysis, the formulations obtained according to the present invention had superior stability over time compared to formulations using undried carriers (shown in Table 1).

In addition, in terms of efficacy, a comparison between the formulation obtained by the present invention and an emulsion-type formulation with the same essence and amount of agricultural chemical active ingredients revealed that the formulation was equivalent in immediate effect, but superior in residual effect. was obtained, and it was found to be excellent in terms of dual safety.

On the other hand, undried water-soluble carriers such as the water-soluble inorganic salts, urea, sugars, etc. are highly deliquescent and tend to have poor fluidity.

For this reason, non-uniformity is likely to occur during mixing (also, special measures such as dehumidifying the inside of the packaging chamber are required when automatically weighing and packaging.

In addition, preparations using only the corresponding anhydrous salt as a carrier have good fluidity when automatically measured and packaged, but when used by diluting and dissolving with water, they form aggregates, making it difficult to obtain a homogeneous solution. It takes more time than necessary to do this, and it also tends to cause clogging of sprayers, etc.

Next, the agricultural chemical active ingredient in the present invention is required to be used in combination with a surfactant that allows a stable emulsion to be obtained in dilution water when used. It can be applied regardless of whether it is insoluble or soluble.

In addition, although the limit amount of agrochemical active ingredients is correlated with the fluidity of the formulation, even when water-insoluble agrochemical active ingredients are used, the water-soluble agrochemicals according to the present invention have less active ingredients than conventional ones. Higher contents are possible.

On the other hand, for example, in the case of a water-soluble agricultural chemical consisting of an aqueous solution of a water-soluble agricultural chemical active ingredient and a water-soluble carrier, it can only be applied at a level below the maximum solubility limit of the agricultural chemical active ingredient in water.

(For example, JP-A-51-54931) Also, water-based solutions containing water-insoluble pesticides as active ingredients are already commercially available, but because the carrier is deliquescent substances such as urea and sugars, they have poor fluidity due to moisture absorption. Therefore, the concentration of agricultural chemical active ingredients is limited to about 10% (W/W).

There are no problems with the stability of the formulation of the water-soluble pesticides and additives of the present invention compared to conventional emulsions and wettable powders. showed that.

The product produced by the method of the present invention can be easily packaged due to its good flowability, and can be automatically packaged in small quantities (e.g., 3-1007 packs) to large quantities (e.g., 20-25 ky). Packaging costs are lower than containers (eg, cans, bottles, etc.) used for conventional liquid medicines.

In addition, this product does not use organic solvents, so it does not pollute the environment, and has other great features such as being highly safe, resource-saving, and not easily affected by costs due to the petroleum situation.

When implementing the present invention, if an active ingredient of agrochemicals that has been approved for use as a drug or quasi-drug by the Minister of Health and Welfare based on the provisions of the Pharmaceutical Affairs Law or the Pharmaceutical Affairs Law is used, it may be used as a drug or quasi-drug. be.

Examples of agrochemical active ingredients that can be used alone or in combination in the present invention include, but are not necessarily limited to, the following.

Insecticides Pyrethroid insecticides such as allethrin, phenothrin, phthalthrin, permethrin, flamethrin, sumicidin, resmethrin, calclophos, chlorpyrifos methyl, siafos, dichlorvos, diazinon, temephos, trichlorhonnared, hyridafention, fenitrothion, fenclofos, fenthion, Organophosphorus insecticides such as bromophos and malathion, carbamate insecticides such as isolane, carbam, propoxur, bunapon, and bassa, and insecticides such as chlordane, tetradifone, and phosalon.

Sulfur-based fungicides such as sarum and zineb, CPA and PCB
Organochlorine disinfectants such as A-PCP, nitrogen disinfectants such as daidzine, phenazine, quaternary ammonium salts, and chlorhexidine, phthalate disinfectants such as cabtane and difortan, organophosphorus disinfectants such as EBP, orthophenyl Diphenyl fungicides such as phenol, and antibiotics such as kasugamycin, streptomycin, and plasticidin S.

Organic herbicides such as herbicide DPA-TCA, NIP/2.4-p
Diphenyl ether and phenoxy herbicides such as A-MCp, triazine herbicides such as CAT, urea herbicides such as DCMU and linuron, carbamate herbicides such as penthiocarb, and organic herbicides such as paraquat and diquat. .

Sorbicidal agents such as zinc phosphide, warfarin, thumarin, silyloside, antu, endox, norpolmite.

Plant growth regulator parapine, polyoxyethylene docosal, polyoxyethylene hekiditane fatty acid, 2-riO/L/ethylphosphonic acid, gibberellin, 3,4-xylyl-N-methylcarbamate, α-naphthalene acetic acid, N- Plant growth regulators such as (dimethylamino)efcinamidic acid and oxoethylene rapeseed oil alcohol.

Spreading agent POE alkyl ether, POE alkyl allyl ether, POE alkyl Z enol ether, POE hexitane fatty acid, paraffin, POE alkylphenyl ether, POE tridecyl ether, alkylaryl polycricol ether, alkylphenol polyethyl glycol ether, turpentine oil, POE allyl ether sulfonic acid, etc.

Examples of surfactants used in the present invention are as follows.

Lauric acid alcohol sulfate ester/alkyl (C6~
16) Benzene sulfonate (NaSK.

Ca, Mg, Zn, Ba, etc.), polyoxyalkylene (C2-4.8) monoalkyl (or alkenyl) (C
1-24) Ether (n = 1-150) / polyoxyalkylene mono (or bis, tris, tetrakis, pentakis) benzyl phenyl ether (n' = 1-200
)・Polyoxyalkylene (mono-penta)styrylphenyl ether (n=1-200)・Polyoxyalkylene (02-4.8) mono[alkyl or alkenyl (
C1-18) phenyl]ether (n-1-150)
Poly(1-200) oxyalkylene [mono, di, triaryl (benzyl, α-methylbenzyl, cumyl, phenyl) phenyl] ether/formaldehyde polycondensate/Po'J (1-100) oxyalkylene (02-
4) (mono(or dinoalkyl(alkenyl, C1-2
4) Phenyl]ether/almaldehyde polycondensate/
Castor oil fatty acid (Na, Ni, Li, Ca, etc.) salts, tall oil potassium salts, sulfated animal and vegetable oils, etc.

Example The amount in the example is 100'? Indicates the weight of the inside.

In addition, solubility in Examples and flowability during weighing and packaging were determined by the following methods.

■ Soluble sample 5? into a 200mA graduated cylinder,
At 20°, add standard 5° hard water to make 100 ml, and invert the graduated cylinder 30 times at a rate of once every 2 seconds until the sample is completely dissolved and emulsified.

■ Fluidity during measuring and packaging We examined whether automatic packaging was easy or difficult to perform using an automatic packaging machine for capacities of 3g, 51.10g, and 20g.

[Model used in this example: “Bi-Packer” model SAM-P
101-B manufactured by Sangen Kikai ■ Co., Ltd.] Example ■ ◎ The components of the surfactant in the examples are as follows.

As shown in Table 1, the stability of the active agricultural ingredient (fenitrothion) over time was compared between the formulation obtained according to the present invention and the formulation obtained using only an undried carrier. It was found that the stability was excellent.

Comparison of effects ■, test sample ■ Water-soluble type (iooy has the following ingredients) ■ Control drug (active ingredient and amount is the same as sample ■, emulsion type) (100 grams has the following ingredients) [1] Efficacy (1) Insecticidal effect on adult house flies using the 1 paper contact method Limited time contact (1 hour) 10 times diluted solution (50ml/m'') (2) Insecticidal effect on German cockroaches using the glass plate continuous contact method 10 times diluted (50ml) /m) *Continuous contact with the same surface The insecticidal effect of the aqueous solvent is equivalent to that of conventional emulsion in terms of immediate effect (immediately after treatment), and the residual effect is ascertained by continuous contact with German cockroaches. As such, the aqueous solvent was clearly superior.

Comparison of toxicity ■, test sample ■ Water-solvent type (contains the following ingredients in 100g) ■ Control drug (emulsion type with the same active ingredient and amount as sample ■) (contains the following ingredients in 100g) Acute oral and As shown in the dermal toxicity test results table, the water-based type was found to be safer than the conventional emulsion type.

This difference is thought to be due to the difference between the magnesium sulfate used in the water-solvent type excipient and the xylene and kerosene used in the emulsion type solvent.

The present invention and JP-A No. 5 when water-soluble pesticide active ingredients are used
Example with 1-54931.

*All amounts below refer to weight per 100g.

In addition, "parts" shall mean "parts by weight."

As shown above, as a result of studying the solubility and fluidity during automatic measuring packaging, we found that the formulation according to the present invention and JP-A-51-5
4931, it was possible to obtain a formulation with higher concentration in the present invention because there is no limit due to the solubility of the agricultural chemical active ingredient in water.

Claims (1)

[Claims] 1 Na2SO4・10H20, MgSO4・7H2
0 or a water-soluble inorganic salt containing crystal water selected from Na2CO3.
Mix a2SO4・10H20, MgSO4・7H20 or Na 2 COs・10H20 with their corresponding anhydrous salts, and mix Na2SO4-10H20, MgSO
4.7H20 or Na2CO3.10H20, the crystal water content of the entire mixture was adjusted to 5 to 95% as a carrier, and a mixture of agricultural chemical active ingredients and a suitable surfactant was added to this and homogeneously mixed. 1. A method for producing a water-soluble agricultural chemical, which comprises mixing with a water-soluble pesticide.