JPS58148962A - Automatic measuring apparatus of erythrocyte sedimentation rate - Google Patents

Abstract

PURPOSE:To measure a large number of samples with high efficiency, by standing still a measuring tube supporting body supporting vetically many blood sedimentation measuring tubes and moving slowly an optical measuring system and measuring a height of a blood column in a blood sedimentation measuring tube by a light source and a measuring instrument for quantity of light. CONSTITUTION:An erythrocyte sedimentation rate measuring apparatus consists of a measuring tube supporting stand 102 being at a standstill supporting vertically many blood sedimentation measuring tubes 105, a light source device 106 being capable of irradiating the whole measuring part of the measuring tube 105 and a measuring instrument for quantity of light 107. This measuring system is moved only along a direction crossing with the measuring tube 105 and it is constructed so that the measuring tube 105 is stand successively between the device 106 and the instrument 107. Moreover, a position of early stage height of a blood column of the measuring tube 105 and the position of height of a precipitated erythrocyte column at every prescribed time elapsed, are measured and the sedimentary length of the erythrocyte at each measuring tube 105 is found by the difference of the early stage value.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an automatic erythrocyte sedimentation rate (hereinafter abbreviated as blood sedimentation) automatic meter. A blood column is formed inside the tube, and the column is stood vertically, and the sedimentation length of the red blood cells is usually visually measured over a predetermined period of time. However, in hospitals with medium-sized facilities and above, the number of specimens is large every day, and the sedimentation distance i of these many specimens can be determined by visual inspection.
Reading 1m is a huge burden, both in terms of time and mentally. Several automatic blood sedimentation measuring devices have been announced to reduce this burden.

One of them includes a photoelectric detector that detects the upper 4rki of red blood cell columns in the measuring tube, and is of a type that follows the sedimentation of red blood cells and moves downward. However, this mounting method requires one set of light sources and photoelectric detectors for one measuring tube, and if you want to measure multiple measuring tubes at four o'clock, you will need the same number of light beams and photoelectric detectors as there are measuring tubes. It has the disadvantage of being expensive because it requires a container.

There is also a device that uses a single set of red blood cell detectors to measure multiple measurement tubes arranged horizontally in a line using this optical power, but in this device the detector is moved in two directions: horizontally and vertically. Another example is to attach a plurality of measuring tubes circumferentially on a rotating body, and attach a measuring tube with an If number - vertically. Attach to,
By rotating the rotating body at the appropriate time, the measurement tube can be sub-localized tI.
After moving to It and stopping it, the light source and photoelectric detector are extended to perform measurement 1, and then vertical force 101 is lowered to detect the upper/ii surface of the red blood cell column (Japanese Patent Laid-Open No. 56 No. 46461, Publication No. 56-46462)a L However, since this method also includes two movements: rotational movement and vertical movement of the light source and photoelectric detector, the structure is complex and failures are likely to occur. In addition, when the VC light source and photoelectric detector are brought out to sandwich the measurement tube, there is a risk of hitting the measurement f, so to prevent this, the stop position of the foot tube, Since a high treetop f is required for the moving @ trace and the timing of driving, it is inevitably expensive.

On the other hand, there is a movement to establish the blood-sinking koji method internationally, and four proposals for an international standard for measuring methods have been underway for several years, and the reality is becoming more and more solidified. VC in this style
ml V If r, set it in a place where there is no vibration, and in order not to move it, there is a soul addition to the body (when the vibration is added to the soul, sedimentation of red blood cells is promoted. In light of this, the scissors 1 described above do not meet international standards and may give excessive measurement results. This is an elegant method that solves the drawbacks and makes it possible to achieve this by simply and gently moving a pair of optical -J byssus while one body is in a stationary state. Therefore, it has the ability to handle a large number of specimens, is inexpensive, has a simple configuration, and is less prone to failure, which means it has a large usability factor.The present invention will be explained in detail below.08g1 The figure and #A2 are an outside view and a front view of the four swords. Reference numeral 101 is a measurement f mounting pedestal, and many of these are arranged circumferentially on the measurement f mount 102.
Around the measurement f mount 1020, an appropriate number of pillars 103 are fixed with lead 111 [K] at appropriate intervals, and a disc-shaped copper foot ffi! A foot plate 104 is provided. This fixing plate has a measuring tube fixed jsc corresponding to the foot measuring tube castle pedestal 101.
The lower end of the measuring tube 15 is pressed against the mounting pedestal 101, and the measuring tube soil part is set to the corresponding measuring tube fixing A. , VC to be subjected to blood sediment measurement
□ 106 #'' TFTM box houses a light source lamp having a long linear filament @ 107 is a light receiving unit box in which an image sensor is housed as a light receiver.

The essence of the present invention is the use of an image sensor as a light receiver, and this idea was born out of necessity. In other words, by using an image sensor, for the first time, the #] constant of the red dish ball and the smoke of the red dish ball can be adjusted to 01 without vertical movement of the nine-point and seven-output devices along the dish sinking #j fixed tube.
As a result, the automatic blood sedimentation device #I, which is inexpensive and trouble-free, can measure a large number of samples using only a single-line operating mechanism.

According to international standards, blood sedimentation is to be expressed in units of 1 meter. Normally, it is necessary to read up to 150 m. Therefore, in order to read the transmitted light t of the blood sediment 1 al 1 foot tube statically [(on the optical measuring thread) without interlocking], in the normal idea, it is necessary to read up to 150 m. Receiver 115011m in size,
This would be a big problem both in terms of cost and technology.Until now, as with existing products, a 1m light source and 1-base lines would have to be lined up in a length of 150 meters, which would be a major problem in terms of cost and technology. The only thing that moves in the right direction is skin.

However, the image sensor has, for example, 28 voices m x 2
512 light receiving parts are lined up at intervals of t-28μ tortoise, and the external dimensions are approximately 24m x 8mm and the length of the base is t.
This is the reason why this image sensor is used.
However, this automatic blood sedimentation machine, which has an unprecedented level of mildew control as mentioned above, is a perfect match for the birth of the foot device.

Blood sediment #] Measurement using the image sensor of the transmission tube
The JFl+ method is as follows: (1) A method in which the erroneous attachment caused by transmitted light 1 is connected as the receiver f of the yt-cisser and Km on the surface using a lens.

(2) Using optical fibers to guide the same light and darkness to the vicinity of the light receiving surface of the image sensor (method...).

The possible errors will be reprinted later using figures.

Here, the light source box 106, the receiver jt, and the S box 107
and is connected by connection 8!108, and this light receiving box 107#i support/drive shaft 109.109'
is held in This support/drive @109 is connected to a motor 110, and the motor 1100 rotations rotate the light receiving unit box 107 and the light source box 106't- connected thereto.

At that time, the light source box 106 and the light receiving unit box 107 are configured to rotate so that the #JW tube is sandwiched between them. Box 107 is placed and l!
ll! Configure it to make one turn. The #J foot 11 is irradiated with light from the light source in the light source box, and the light transmitted through the measurement tube is detected by the light receiving section. Since the upper surface of the sedimented red blood cells is transparent plasma, it passes through the irradiated area and reaches the light-receiving area, but the upper four surfaces of the sedimented red blood cells and below are opaque, so the source of the irradiation to this area does not pass through, and therefore does not reach the receiving section. Utilizing this phenomenon, it is possible to drive the boundary between likely transmission and non-transmission by photometry at the receiving section. Blood sedimentation can be measured by adding #j to the difference from the blood height position.

Normally, this method is sufficient, but if a drop of blood occurs during the measurement time (usually 1 hour for 2 hours), the error will be reduced by the amount of the drop in overall medical treatment due to the leak. arise.

The amount of light transmitted through the blood sedimentation measuring tube after erythrocyte sedimentation was examined in more detail by 1lli*L, and the following results were found: (1) The part of the sedimented red blood cells is of course completely dark because no light is transmitted through it. It is.

(2) The upper part containing plasma is bright because it is transparent to t.

(3) It becomes dark due to the partial Fi layer folding phenomenon in the air above the plasma.

From the above circumstances, it was confirmed that the boundary between air and plasma can also be detected optically. Therefore, if we measure the height position of the plasma level and the height position of the upper end surface of the sedimented red blood cell column as time passes, and then measure the blood sediment I#L from the height position 21, the blood Errors due to leakage can be prevented.

By driving the 1rOL7%-/-110, the optical miscellaneous box 106 and the light-receiving unit box 107 rotate as one, and the control tubes are configured to pass one after another into the gap between them. Therefore, the blood deposits of a large number of set structures can be automatically determined. The rotational speed f may be slow because the blood sedimentation cycle 1 is normally measured only after 30 minutes, 1 hour, or 2 hours have passed. In other words, it only performs simple movements slowly, but unlike conventional devices that perform complex movements, the configuration is
Therefore, it is inexpensive and less prone to damage due to force.

Also, unlike the previous four examples of conventional devices, the optical detection system does not move the small foot tube during movement #1, so it is possible to automatically perform foot #j that meets international standards.

Now, Fig. 3 shows an example of the method of using a lens.
11 is a light source, 112 is a blood sediment measuring tube, 117 is a convex lens,
118 is an image sensor. #I fixed view sink nm
The image is projected onto the f-receiving surface of the image sensor by the i-lens*1. , which was taken as a signal and read in its entirety.

In addition, Figure 4 shows method +2 using optical fiber.
) fll't'6 7111 #'1fll, 11
2 H#J? iF, optical fiber to 113,
114tjl13 One end is lined up and held in a row #I foot v
115 is the optical fiber 1130 tube placed 4 in the vicinity of the image sensor 9! This is the part that is held by the lid in accordance with the shape and arrangement of the light surface.

In FIGS. 3 and 4, the light source is shown as a true lamp with a long straight filament 200 pointing south, but other lamps with an ordinary point filament may be used and the required IC
You may also adopt a method of irradiating the entire measurement area of blood sedimentation koji fixed blue using a suitable lens and a lens.

And as mentioned above, the original $111 was put into the light beam Bottas log, and the Mayu glass fiber part image sensor
Or the j1 combination of the lens and image sensor is
It is housed in a light receiving unit box 107. Note 1 [Box, 9! Inside the main box are the scales of the above parts, the light source 1111 and receiver for distinguishing whether or not the foot tube is visible, and the light source 1111 and the receiver for distinguishing whether or not the foot tube is visible, and the light source 120 + the light source 1111 for the light source 1111 and the light source 1111 for distinguishing the presence or absence of the foot tube.
121 or receiver 122 may be stored.・Helmet, I
A method for determining the presence or absence of the I constant constant plate is to use a pressure switch.For example, a method for reading the position number is to insert a position number discrimination hole 123 in a part of the measurement g fixing plate 104 to the position where the #J constant current tube is attached. It is provided correspondingly to the
There is a method in which the position number discrimination hole is sandwiched between the i121 and the light receiver 122.
For example, as shown in FIG. 5 [7], it is possible to discriminate positions within 63j1! by combining the hole openings at six positions.

In Figure 5, the solid line circles indicate the actual holes, and the dotted lines indicate the positions where holes should be drilled if necessary.
This indicates that no holes are actually made, and if the number of holes is increased to 8, it becomes possible to classify up to 225 positions. The position discrimination method described above is a method of detecting the presence or absence of light incident on the photoreceiver based on the presence or absence of a hole. ! , a light source and a light receiver may be provided in the same direction, such as by painting a light source and a light receiver, and detection may be performed using reflected light.

Reference numeral 124 indicates a foot position tIt sign indicator light, which is provided with at least the number of measuring tubes that can be attached.
Step 7 prints out the blood sedimentation measurement result along with the tube measurement position number, etc. 126.127/fi Equipped with power switch, computer, etc.

Next, the determining operation and function N of the device according to the present invention will be described.

1, l)! ! Collect a sufficient amount of blood sample tubes into the I leg tubes, and set the appropriate number of tubes on the measuring tube mount 102.

2. Turn on the switch (you may turn on the switch first and then perform the above step 1). 0 3 Gengaku thread 106 and 107 rotate, and check whether the #J foot tube is installed or not, the source 119 and the light receiver 120 In places where the #1 fixed tube is installed, the receiver 12
(can be distinguished by the transmission of incident light to 0),
If the #Iw tube is attached, its position number is read and memorized by the light source 121 and light receiver 122, and at the same time, time measurement for that position number is started. At the same time, it would be convenient to display this using a lamp corresponding to the value of 81ρ to display ff1124.

4. -7t, academic system 106.107 continues to rotate,
Time after starting measurement (e.g. 30 minutes, 1 hour, etc.)
When it reaches the position of the foot tube after passing through, the sedimentation length is measured and at the same time, the position f is also read and memorized.

＆ Measurement time required (usually 1 or 2 hours)
For the measuring tubes for which the process has been completed, the sedimentation length is printed on the printer 125 along with the position number. At the same time #11th place ti
[The value of the number indicator light If the number indicator lamp is configured to indicate this, the measurement tube with the whole blood sample and the # in the place of that number should be removed. It is convenient because it is easy to identify whether it is a sword or a sword.

In this case, to distinguish that the measurement 'tirlCWIt has changed, for example, '5' is changed from the light receiver 119 to the light receiver 1.
Due to the presence of the measuring tube, the incidence on 20 was blocked by a friend, but due to the father's dislike of the measuring tube, a friend temporarily fired into the receiver.
Rental room 1 with detection or measurement observation due to being crossed again
A pressure switch is provided at the bottom of 01 or the top of the measuring tube i11] 1 due to constant bud delayering! How to detect from change in number,
Alternatively, there is a method of installing a 4-conductor rubber instead of a pressure switch and detecting the change in conductivity (electrical resistance) when the redundant tube is attached or removed. And after completing the measurement, you will meet your new friend, the measuring tube! For those that were seen, please refer to the @ covered soil F3
The movements of a widow are performed.

The above is an outline of an example of the operation and function of the automatic blood sedimentation device according to the present invention.
It is possible to automatically measure the blood sedimentation values of a large number of specimens while the device is kept stationary at i'.

(2) Since a large number of measurements are carried out using a set of optical #1 byssus threads, there is no separation from the conventional apparatus in which each measuring tube is provided with an optical measuring thread.

(3) Since the movement of the optical measuring thread is simple and slow, it can be constructed inexpensively and is less likely to malfunction, unlike conventional devices which have rapid and complicated movements.

Large young fruits as shown above can be obtained.

[Brief explanation of the drawing]

FIG. 1 is an external view of an embodiment of the device of the present invention, FIG. 2 is a front view thereof, and FIGS. 3 and 4 are illustrations using a lamp having a long linear filament as the light source. , FIG. 5 is an example of the position number discrimination hole shown in FIG. 102...Measurement f mounting base 105...
・・・・・・・・・6 Jiri ni 106・・・・・・・・・
・・・Yu-bosokusu 107・・・・・・・・・・・・
Receiving box 109, 109'...Support drive shaft 110...Motor Fig. 1 Fig. 2

Claims (6)

[Claims] (1) Erythrocyte sedimentation length measurement system consisting of a stationary measurement tube support supported by a large number of blood sedimentation measurement tubes 1, a main II device that illuminates the entire measurement section of the blood sedimentation #1J foot tube, and a light intensity meter. , the blood sedimentation measurement thread is moved only along the direction across the blood sedimentation measurement tube, and at that time, the blood sedimentation #J foot tube is interposed between the light source and the light amount measuring device for the first time in a while, and each The initial height position of the blood column surface of the blood sedimentation measuring tube and the height position of the sedimented red blood cell column of each blood sedimentation measuring tube are measured every predetermined time period, and the value of each blood sedimentation measuring tube is calculated from the above-mentioned initial J & 8 value. Erythrocyte sedimentation column foot device to determine the erythrocyte sedimentation length. (2) The light amount measuring device is an image sensor, and the light from the original force is radiated to the blood sedimentation #] constant f, and the image sensor uses a lens to measure the brightness generated by the appropriate amount of light from the blood sedimentation measurement tube. I#F characterized by forming an image on a surface and measuring the erythrocyte sedimentation length from the output signal of the image sensor.
F Claims WI Group 1 Item 1 Software device. (3) The jt, t#J meter is an image sensor, which irradiates the blood sedimentation measurement II with '1 from the light source, and measures the amount of transmitted light in each part of the blood sedimentation measurement tube using a large number of #IIIK arrays on four sides. A patent claim characterized in that light is received by an optical fiber, the other end of the optical fiber is placed near the image receiving surface, and the erythrocyte sedimentation peak length is measured from the output signal of the image sensor. Apparatus according to item 1 below. (4) Erythrocyte sedimentation sieve length #1 foot system consisting of a stationary measuring tube support that vertically supports a large number of blood sediment measuring tubes, a hanging light source device that illuminates the entire measuring section of the blood sediment measuring tubes, and an f position measuring device. 'f, the measurement system is moved only in the direction across the blood sedimentation measurement tube, and the blood sedimentation measurement tubes are successively interposed between the 1IlK particle source and the light amount constant device. Erythrocyte sedimentation is performed by measuring the height position of the plasma surface of each blood sedimentation measuring tube and the height position of the upper end surface of the sedimentary red blood cell column, and calculating the erythrocyte sedimentation length for each blood sedimentation measuring tube from the difference between the two height positions. Speed automatic measuring device/ (5) The light 1 measuring device is an image sensor, and /l from the light source is irradiated onto the blood sediment measuring tube f, and the brightness and darkness caused by the amount of light transmitted through the blood sediment measuring tube is condensed onto the light receiving surface of the image sensor using a lens. 4. An apparatus according to claim 4, characterized in that the erythrocyte sedimentation rate is added by 11111 from the output signal of the image sensor. (6) The filiil meter is an image sensor, which irradiates the blood sediment #j foot # with the source from the light source, and measures the amount of transmitted light of each part of the blood sediment measurement tube by arranging the four sides vertically and using a large number of optical sensors. Claim 4: Receiving light through a fiber and measuring the settling length of the sphere.
Tomukiro's device 0