JPS58144733A - Self-aligning device for nuclear magnetic resonance - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention is based on the present invention, in which the volume magnetic susceptibility including the sample tube of each sample is different from the reference line on the recording paper in a nuclear magnetic resonance apparatus, and the resonance line of the standard material and the reference line on the recording paper are different from each other. The present invention relates to a device that automatically matches a slight deviation with a reference line.

A conventional automatic positioning device is known in No. 45-128536, in which a photosensitive element is installed in the pen rider of the recording needle, a light source lamp is provided at a specific position on the recording paper, and a potentiometer is used as a storage device. It is mechanically complex, such as using a flange to detect the circuit angle, and furthermore, since the detection correction operation is performed before the recorder starts (further to the left of the left shoulder 10 ppM), the recording needle has a membership fee for taking a preliminary operating range before starting. The effective recording period becomes narrower within this range.

In addition to matching the reference line of the recording paper to the resonance +111 that differs from sample to sample, we also have a circuit that detects the resonance line of the standard material in the reference measurement of the measurement song, determines its position, and memorizes the period. It is equipped with a shibuto circuit to determine the position using the first signal that is swept from the left shoulder of the recorder.

In order to match the resonance line of the standard material with the reference line of the recording paper in a single alignment operation, only the resonance line of the quasi-substance is shifted from near the right end to near the left end, and then the recording needle is moved to the left end by 10 ppM. The resonance line of the standard material can be traced to the left y! of the recording paper by sweeping further, storing the sweep voltage up to this resonance signal, and calculating the stored voltage to the sweep amplifier at the same time as the resonance signal is reached. tA101) Shift up 9M. In this state, the left ys10pI) of the recording paper is 4 to the right from M.
By shifting to 0 ppM, it can match the reference line of the recording paper.

In Figure 1, 1 indicates a constant frequency (e.g. 60MHz
), which applies a DC magnetic field generated by a magnet, for example, a high-frequency magnetic field to the sample 2 placed in a Tesla. By changing the DC current applied to the magnet coil 3, the DC magnetic field is swept, resonance of hydrogen nuclei in the sample occurs, an induced signal is obtained, which is transmitted through the amplifier 18 and recorded as a spectrum on the recording paper 4. Ru. In this case, the recorder Ben 5 sweeps from left (10 ppM) to right (OppM),
The sweep source is a so-called digital sweep 17, which divides the value from a clock oscillator and passes the value through a D/A converter. It is supplied to the axial amplifier and provides the recording paper 4 with a spectrum linked to the sweep. If it is possible to match the resonance @9 of the standard JR (usually tetramethyl 7 run, abbreviated as TMS) contained inside the sample with the standard 4817 on the recording paper and record it, it will be extremely convenient for spectrum analysis. This is naturally required for the purpose of using a calibration chart, and conventionally, in a preparatory measurement before recording, in order to match the TM8 resonance 119 with the reference line 7 on the recording paper, the DC magnetic field sweep intensifier 6 is manually operated. A correction voltage was applied from the potentiometer 8 to match the reference line 7 to shift the magnetic field. These operations require repositioning each time you exchange sample 2, since the true DC magnetic field that the atomic nuclei in the sample receive is slightly different because each sample has a different volume magnetic susceptibility including the sample tube. It becomes necessary. In the present invention, the positioning operation is automatically performed without relying on the adjustment of the potentiometer 8 described above.

separating the resonance signal of the spectral signal by a separator 10;
The signal from this separator operates the switching circuit 11, which connects the controlled relay 12.

On the other hand, the digital sweeper 17 is connected to the memory circuit 14 via the contact At of the relay 12, and its output is the N of the C contact,
It is connected to the sweep amplifier 6 via O and common. Also, the Be point of the relay 12 is configured to be self-holding via a spring-backed push button switch. On the other hand, the D contact of the relay 12 is connected to a constant amount of power supply 15 for shifting the current magnetic field, as well as 16 is applied to the n1 magnetic field return amplifier. The operation of the present invention will be explained with reference to FIG.

The two sides of the spectrum 20 where the resonance line of the standard material TMS appears to the left of the reference line 7 on the recording paper and the spectrum 29 where the resonance line of the standard material TM8 appears to the right of the reference line 7 will be described.

f#, press the pushbutton switch 13 in Figure 1 to cancel the output level of the memory circuit 14 and also to cancel the relay 12.
All contacts are connected to the N and 0 sides, and the Spectrum 20 and 290 Goshift power supplies 15
Therefore, the shift magnetic field ΔH is shifted to the left by 22 and 31. ΔH, rilOp1) A shift width smaller than M is assumed to be provided.

This is done on the recording paper in preparation for the alignment operation described later.
This is to separate only the signals. Next, sweep the recording needle ben from the left shoulder to begin the alignment operation. spectrum 25
And as shown in 34, the DC magnetic field change ΔH123 from the left shoulder
At 32, the switching circuit 11 is activated by the credit card component of the TMS from the separator 10, and the relay 12 is connected to N,
It switches to 0111. During this time, the memory circuit 14 receives a voltage Δ■, 2 corresponding to the change in the DC magnetic field from the left shoulder of the recording paper.
4 and 33 are memorized, and at the same time as the aforementioned relay switches, the memorized voltage ΔV is added to shift the magnetic field sweep amplifier 6 by ΔH3, and the spectrum is shifted far to the left end of 26 and 35. At the same time, the D contact of relay 12 causes a shift voltage @16 to shift the magnetic field H( ) (is exactly 10 pI) M from the left edge of the recording paper to the right shoulder.
is the shift width corresponding to ) A voltage is applied to the spectrum, and the resonance line of the standard material TM8 of the sample matches the reference line of the recording paper as shown in 27 and 36, and this state is self-maintained by the B4i1 point of the relay 12. At the same time, the display lamp 38 lights up to notify that the reference edge VC base has been matched. When replacing the sample, push button switch 13
Press to cancel the memory circuit 14, release the self-holding of the relay 12, and repeat the above operation. With the present invention, the operations required for preparatory measurements for each sample exchange are performed once, and the measurement time is significantly reduced, which is a great selling point. .

[Brief explanation of the drawing]

Fig. 1 is a circuit route diagram showing one embodiment of the present invention;
The figure shows a detailed diagram of the alignment of the spectrum.

Claims (1)

[Claims] 1. In a method in which a constant high-frequency magnetic field (1) and a swept DC magnetic field intensifier (6) are applied to a magnet coil (3) to a measurement sample mixed with a standard substance to record a nuclear magnetic resonance spectrum signal, the standard ! ! i! From (7), the magnetic field is shifted by ΔH9 to correct the shift ΔHt between the shift power supply (15), the reference line (7), and the resonance line of the standard material. 14) 1r preparation,
A nuclear magnetic resonance automatic positioning device that adds the above-mentioned deviation magnetic field to a magnetic field sweep amplifier in advance before the main measurement, and automatically matches the resonance line of the standard material with the reference line on the recording paper.