JPS58127655A - Centrifugal automatic plasma exchange device - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an automatically operable centrifugal plasma exchange apparatus.

There are currently two types of plasma exchange devices: a membrane separation method and a centrifugal separation method, but the present invention collects blood, separates the blood into blood cell components and plasma components using a centrifuge, and separates the plasma components into separately prepared blood cells. This invention relates to a centrifugal plasma exchange device that returns blood after exchanging it with fresh plasma. Conventionally, there was a system in which blood was collected, separated into blood cell and plasma components using a centrifuge, exchanged with fresh plasma, and then returned. The blood return system had the disadvantage that it was all manual operation and was very time consuming.

Therefore, the present inventor conducted various studies to overcome these drawbacks, and found that when the centrifugal bowl is almost full of blood cell components, a signal from the blood cell detector that can distinguish between blood cell components and plasma components is detected. As a result, a system was created in which the process of blood collection and separation of blood cell components and plasma components is stopped, and the process of mixing fresh plasma and blood cell components using a mixing pump is started.

In addition, you can arbitrarily set the time from the start of blood collection until the centrifuge bowl is almost filled with blood cell components, and when the set time ends, the blood collection and blood cell count will start.

A system was also created that stops the process of separating plasma and l'I'l'I plasma and starts the process of mixing fresh plasma and blood cell components using a mixing pump. Therefore, the object of the present invention is to
In a centrifugal plasma separator, blood is taken out by a blood collection pump, guided to a centrifugal bowl, separated into blood cell components and plasma components, and the separated plasma components are taken out. a step of separating fresh plasma by subtracting a set amount of water from the separated plasma using a mixing pump and storing it in a blood transfusion bag while mixing it with the blood cell components; and then returning the blood using a blood return pump. An object of the present invention is to provide a centrifugal automatic plasma exchange device characterized in that it is configured to automatically repeat these steps in sequence.

In addition, in the centrifugal automatic plasma exchange device, the process of blood collection and separation of blood cell components and M1 plasma components is stopped in response to a process switching signal from a blood cell detector capable of distinguishing between blood cell components and plasma components. It is preferable to configure the device to start the step of mixing plasma and blood cell components. Furthermore, in the centrifugal automatic plasma exchange device, the time from the start of blood collection is arbitrarily set, and the process of blood collection and separation of blood cell components and plasma components is stopped by a process switching signal issued when the set time ends. It is preferable to start the process of mixing fresh plasma and blood cell components. in this case,
Accurately predicting and setting the time until the centrifugal bowl is almost filled with blood cell components is extremely difficult due to variations in the flow rate of the blood collection pump and differences in the hematocrit value of the collected blood. Therefore, it is preferable to use a system that switches processes based on a signal generated by detecting blood cells using a blood cell detector.

Next, the centrifugal automatic plasma exchange apparatus according to the present invention will be described in detail below with reference to the accompanying drawings.

FIG. 1 is a system diagram of a centrifugal plasma exchange apparatus according to an embodiment of the present invention.

Blood collected by the blood collection pump/ is guided into a centrifugal bowl/3 in a centrifuge λ, and is separated into blood cell components and plasma components by centrifugal force.

Plasma components with low specific gravity flow out from the centrifugal bowl/3 into the collected plasma bag r via the switching valve bag R before the blood cell components. This is the blood separation process.

When the outflow of plasma components is completed, blood cell components with high specific gravity begin to flow out from inside the centrifugal bowl/3. When the blood cell detector 3 detects this blood cell component, it sends a signal to the process switching circuit/l, and sends a stop signal from the knee and culm switching circuit/6 to the blood collection pump l and the centrifuge. When the blood collection pump/centrifuge λ is stopped, the process moves to the next blood mixing step.

In the II'IN liquid mixing step, a drive signal is sent from the process switching circuit/6 to the mixing bomber, and by operating the mixing bomber, the amount of fresh plasma calculated by subtracting the water removal set amount from the separated plasma calculated by the calculation control circuit lj is generated. Plasma is switched (Lupug,
The returned plasma is sucked into the centrifuge bowl 13 from the returned plasma bag 7 via the tube B. The fresh plasma aspirated into the centrifugal bowl 13 is
It is stored in the blood transfusion bag 10 together with the blood cell components separated in the blood separation process.

The amount of blood calculated by the arithmetic control circuit/O is transferred to the transfusion bag i.
When stored in o, the arithmetic control circuit / j to process switching circuit /
2, and a stop signal is sent from the process switching circuit 16 to the mixing bomber. When the mixing pump stops, the process moves on to the next blood return process.

In the blood return process, two culm switching circuits/& blood return pump//
The hetribe signal is sent, the blood return pump // is operated, and the blood is returned to the living body via the bubble detection 'a7.2 as a safety device.

When the dark blue blood computed by the arithmetic control circuit/j is returned, the arithmetic control circuit 15 issues a signal to the process switching circuit/B, and the process switching circuit/B sends a stop signal to the blood return pump//. send.

When the blood return pump l/ is stopped, the process moves to the blood separation process again.

This blood separation step, blood mixing step, and blood return step are successively repeated. In this device, fresh plasma is transferred from the return plasma bag 7 to the transfusion bag 10 by setting the water removal amount using the water removal amount setting device /g and controlling the switching of the switching valve and O using the arithmetic control circuit /j. Suction and delivery.

In addition, instead of the water removal M setting device/≠, the blood transfusion bag L is set using the hematocrit value setting device.

The arithmetic control circuit /j works so that the ITII liquid stored in the hematocrit value reaches a preset hematocrit value, and can control the switching timing of the switching valve and z.

Blood cell detectors include ultrasonic detectors that use ultrasonic sensors, and photoelectric detectors that use photoelectric sensors! ! ! There are dark blue type detectors using 'f sensors, etc., and a block diagram of a photoelectric type detector is shown in Fig. 2.

/7 is a photo sensor, /I is a comparator, / is an oscillator, 20 is a counter circuit, and 21 is a monomulti circuit. A comparator/g was inserted to clearly distinguish between the plasma detection level and the blood cell detection voltage level of photosensor/7.

In addition, white foam is generated in the initial state when plasma components flow out of the centrifugal bowl/3.

Since the detection voltage level of the white foam and the blood cell detection voltage level are almost the same, there is a possibility of misidentifying white foam and blood cell components. In order to prevent this, an oscillator/counter circuit 2o is inserted to distinguish between bubbles and the m11 component based on the detection time.

When the photo sensor 17 detects blood cell components using the circuit shown in FIG. 2, a one-shot pulse is generated from the output of the monomulti circuit 21.

As is clear from the above description, according to the present invention, each process is switched by using a blood cell detector that can distinguish between blood cell components and plasma components, or by arbitrarily setting the time until the blood cell components are filled. This allows automatic exchange of plasma.

In addition, in this device, the pump flow monitoring circuit and the air bubble detector 7.2 in the blood return line are essential for safety.
Needless to say, if the flow rate of the pump is abnormal, or if the bubble detector/2 detects bubbles, all operations are stopped and an alarm is issued.

4/, 1 Brief description of the drawings Fig. 1 is a system diagram of an embodiment of the centrifugal automatic plasma exchange apparatus according to the present invention, and Figs. 2 and 2 are diagrams of an embodiment of the photoelectric blood cell detector used in the present invention. Block diagrams are shown for each.

／ ・・・・・・・・・Blood collection pump ／j ・・・
・・・・・・－・ Arithmetic circuit ・・・・・・・ Centrifuge /2 ・・・・・・・・・ Process switching circuit 3
・・・・・・・・・Blood cell detector /7 ・・・－・
・・・・・・ Photo sensor data ・・・・・・・・・Mixing pump 7g ・・・・・・・・・ Comparator 1
0...Blood transfusion bag /ta...
...... Oscillator // ...... Blood return pump 20 ...... Counter circuit /3 ...... Centrifugal bowl 21 ・River・Song: Mono-multi circuit/G ・・・・・・・・・Water removal amount setting device patent applicant Nikkiso Co., Ltd.

Claims (3)

[Claims] (1) In a centrifugal plasma separator in which blood is taken out by a blood collection pump and guided to a centrifugal bowl to separate blood cell components and plasma components, and the separated plasma components are taken out, blood is collected by a blood collection pump and guided to a centrifugal bowl. The process of separating blood cell components and plasma components, and sucking the fresh elm m + serum obtained by subtracting the set amount of water removed from the separated plasma using a mixing pump, and performing step 1 above! A centrifugal automatic plasma exchange device characterized by being configured to automatically repeat in sequence the steps of storing blood in a blood transfusion bag while mixing it with the It cell component, and then returning blood with a blood return bomb. . (2) Nl- that allows discrimination between blood cell components and plasma components
A patent that is characterized in that the process of blood collection and separating blood cell components and plasma components is stopped, and the process of mixing fresh plasma and blood cell components is started by a process switching signal from the bulb detector. The centrifugal automatic plasma exchange device according to paragraph (1). (3) The time from the start of blood collection is arbitrarily set, and the process switching signal issued when the set time ends stops blood collection and the process of separating blood cell components and plasma components, and separates fresh plasma and blood cell components. Centrifugal % type % according to patent claim paragraph (1), characterized in that the mixing step is started.