JPS58116337A - Apparatus for analyzing pulse curve - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an electronic device for observing or measuring the properties of blood circulation in a living body.

The sustenance of life and the viability of tissue cells depend on the physiological movement of blood circulating in the capillaries.
I is maintained by a network of small vessels, within which capillary circulation takes place between arterioles and venules.The capillary system is the point of contact between arterial and venous blood throughout the body. The small force canal circulation is commonly referred to as the microcirculation.

Blood volume is maintained by microcirculation and macrocirculation.

The macrocirculation includes blood vessels other than the microcirculation and the heart.

Typical 1/e parameters such as electrocardiographs and sphygmomanometers are related to general circulation. Macrocirculatory parameters do not measure or reflect microcirculatory fluctuations or capillary activity.

The Stifnes Tissue Perfusion Monitor or 8TPM (Australian Patent No. 465302) samples and quantifies signals from the capillary circulation near the skin surface and generates colorimetric measurements without violating the skin's microcirculation. Since the measured value, i.e., the tissue perfusion rate, can follow the microcirculation wave, it is possible to detect changes or stabilization of the activity of the nozzle-like microcirculation at the capillary level with respect to the absolute reference voltage (i.e., 5119 mV). Display of sexuality?Give.

However, blood flow is a rhythmic activity that can give an accurate mathematical representation of the curve shape in a series of analog pulse curves. Despite the value of e-parameters, such as the tissue perfusion rate TPI, existing tissue perfusion monitors do not identify convoluted curvature relationships that have the same area immediately below them.

Therefore, it is an object of the present invention to obtain more information based on the shape of the Nozzles curve. Therefore, analog Noguru curves from microcirculation or macrocirculation sources can be monitored and their differences measured and compared.1 Various factors influence the pulsed microcirculatory flow and its It is known to vary the shape or amplitude of a curve, as well as both. Measuring these changes
Therefore, all diagnostic information can be added.

Furthermore, it is an object of the present invention to set a noggle meter related to the shape of the Noggles curve to the curve rise time Tr or the curve fall time Tf.
Analyze and display 1+ the rise/fall ratio of the curve and the rise time Tr for the pulse period and the fall wait time f
The objective is to analyze and display relevant parameters.

Yet another object of the present invention is to identify the positional presence of pressure waves such as dichroic steps in the fundamental curve cycle and to indicate substantial power factor matching and variation.

Yet another object of the present invention is to identify the complete presence of pressure wave effects such as dichroic steps in the fundamental curve cycle and to indicate substantial discrepancies and fluctuations.

In certain embodiments of the invention described below, the rise time T
r (milliseconds), fall time Tf (milliseconds), rise time TR/TF of the Noggles curve expressed in direct relation to the fall time or rise or fall expressed as a fraction of the curve cycle period Time Tr/T or Tf/T
Continuous reading is performed for.

The data relate to the rate of the rate of the tube formation in absolute milliseconds. In the case of capillaries, the physiological mechanism involved in the analog curve rise time is the capillary load Vc9! in the microcirculation. The typical adult digital load time results in considerable variation in the fall time, which corresponds to the decreasing phase of the cycle, and is about 0.2 seconds. Regarding changes in pulse rate.

This is sometimes due to pathological disturbances.

Therefore according to the invention. Nozzles curve analyzer.

a photoresponsive transducer that detects the patient's continuous physiological circulatory function to produce a voltage waveform that resembles a pulsed color or blood concentration or both changes in the patient's body tissues; a device for forming an output signal tube proportional to the time rate of change in the amplitude of a waveform; and a device for quantitatively and instantaneously measuring the rise time and/or fall time representing a transient cycle of said waveform as a function of the period of said cycle. and a display device.

Hereinafter, the 5Jl embodiment of the present invention with all accompanying drawings will be described in detail.

In the figure, the transducer is e.g. Australian Patent No. 46
The electrical signal is extracted from the patient's body in a manner similar to that described in the '5302 specification.For convenience, this signal may be taken from the QSTPM's Norse Curve and Pulse Rate output terminals which are supplied to an analog curve analysis monitor.

When applying the specific transducer described above to the surface of mucous membranes or skin, the following signals are extracted.

Light from a light source within the transducer assembly
The modulated light is modulated by the change in force, and this modulated light then impinges on a detector that produces a waveform signal. The resulting waveform signal passes through a notch filter.

This filter is used to remove nower frequency interference from the alligator straddle optical pickup. This filter is a standard duplex T tuned to suitably ie 50 or 60 Hg.
Has circuit gold.

['L10 is used to match the filter to the center frequency of the interference. The signal is then passed through an operational amplifier U1 with an adjustable gain ranging from 25 to 65 dB. The output of this stage is buffered by Umaro #C and has a frequency of 8TPM.
It is also passed through 8TPMK to feed OaO displays located elsewhere.

The output of Ul is also passed through Ul, which differentiates the pulse curve. Thus, the output of US is the input voltage Qj
a that is proportional to the time rate of J change acts as a two-pole low-pass filter with linear phase; when biased appropriately (one for R14), the output of Ul will rise as a Norse curve voltage. The magnitude of this differential voltage will be negative when the pulse curve voltage falls and will remain positive when it falls! -g is proportional to the magnitude of the input voltage and the time rate of change.

The siemit trigger U increases the output of Ul squarely, and this increased output then becomes Ul −I FLsy~
44 and 701 to the detector/filter with ports. The output of these two detectors is the partial rise time (R
4) and the partial fall time (844).

These outputs are partial to the Nogles period and therefore complementary.

A multiplexer from U, and U9 is used to add to the selected set of inputs kUγ, making this a true ratio voltmeter integrated circuit. It is displayed by applying the standard voltage from the partial rise and fall time values Rlj to the reference input and the output of the appropriate detector to the signal input of the digital voltmeter. Actual curve rise and fall times in milliseconds are displayed by applying the appropriate detector output to the voltmeter signal input and a voltage proportional to the nozzle slate obtained from 8 TPM to the reference input.

In another embodiment, if desired, the ratio of rise time to fall time can be expressed by adding the output of the rise time detector to the total signal input and the fall time detector output to the reference input.

The calculated output is serialized numerically from the LCD output, which in this example is driven by Ut.

, the product of e-rus period T and Tr/T can be expressed as minute vr ring negative load time rate (milliseconds). ttaT and Tf
/T can be expressed as the delay phase rate TfC milliseconds].

Information can be provided in a variety of different formats.

(1) Rise time (milliseconds) Tr (b) Fall time (c milliseconds) Tf (c) Rise time divided by the Norse period Tr /
T(d), fall time divided by R pulse period Tf/
T(e) Rise time divided by fall time T r /
If required, the readings of Tr/T and Tf/T or Tr/Tf may be selected by a multi-position switch using the array tube shown in Figure 10, so that Tr/Tf
(i.e. the ratio of rise time to fall time) When the rise time changes, there is a slight increase in the falling time corresponding to a decrease in the fall time F: tTr r/Tt or Tf/T
When the denominator is constant, as in , Ririri is more sensitive to changes.

The present invention shows that physiologically meaningful changes in rise time to fall time ratio readings are not necessarily related to TPI readings normally obtained from patients.

In other words, the Nozols curve analysis device constructed according to the present invention provides information from the Nozols curve.

This information can be displayed with accurate measurements of Hayabusa kills,
You can't get this even with a Nogurus monitor or a dense 8TPM. Any other additional equipment useful for providing auxiliary representation of curved shapes? Although it may be used, it does not provide absolute value measurements as the ORO knee curve analyzer does in digital or analog form as desired.

Thus, in summary, a knee curve analyzer can be configured to extract information from a voltage waveform coming from a transducer placed on the skin or mucous membranes. The transducer may be optical.In the case of the activity of the capillary blood circulation, information regarding the oxygenation and deoxygenation (depletion) phases of the capillary blood appears in the voltage waveform.

This waveform has a fundamental frequency equal to the patient's Norsrate or heart rate.

[Brief explanation of drawings]

Figure 1 is a graph showing a mathematical representation of a pulse curve drawn with amplitude 1 versus time; Figures 2 to 5 are the circuits of a tissue perfusion monitor; Figures 6 to 11 are the circuits of a pulse curve analyzer. ,
? Fig. 6 is a circuit diagram showing a ■-type filter and input amplifier, Fig. 7 is a circuit diagram of a differentiator, low-pass filter, and Schmitt trigger, and Figs. 8 and 10 are a circuit diagram showing a detector and multiplexer. FIG. 9 is a circuit diagram showing a digital display meter, and FIG. 11 is a circuit diagram showing a power supply w=nit. 8 TPM...Signal supplied to analog curve analysis monitor, U! ... operational amplifier, Ufi ... Schmidts)
) Riga s Ul @ Ul...Multiplexer, T
...Resistance period, Tr...rise time, Tf...
Fall time. Patent Applicant Frederick Richard IIson
Staphns

Claims (4)

[Claims] (1) A photoresponsive converter that detects the patient's continuous physiological circulatory function and forms a voltage waveform in response to pulse-like blood color or blood concentration changes in the patient's body tissue; and a photoresponsive converter that processes the waveform to form the waveform. a processing circuit that forms an output signal proportional to the time rate of change in the amplitude of the waveform, and the rise and fall times representative of the transient cycles of said waveform. A nosolus curve analysis device characterized by: means for quantitatively and instantaneously displaying t-Jj as a function of the period of the cycle. (2) The pulse curve analyzer according to claim 1, wherein the transducer is responsive to light modulated by changes in capillary blood circulation function. (3) In the processing circuit, the output of the converter is applied to a V-type filter, the output of the filter is applied to an operational amplifier, and the output of the operational amplifier is buffered. #, and the differentiator output is applied to a low-pass filter having a linear phase, the low-pass filter being biased so that the output voltage of the filter is biased when the voltage waveform rises. Claim 1 is characterized in that the voltage waveform is negative, positive when the voltage waveform falls, and has a magnitude proportional to both the amplitude and the time rate of change of the voltage waveform. ) The iR Lux curve analyzer described in item 1. (4) The voltage output of the low-pass filter is squared by a Schmitt trigger and then applied to a dual detector, each output of which is determined by the rise time of the portion of the voltage waveform relative to the Nozzle cycle. Proportional to the fall time, the output of the detector is applied by a multiplexer to a selection paper input of a ratio voltmeter integrated circuit, whereby the value of said time is displayed. (3
) The iR Lux curve analyzer described in item 1.