JPS5795917A - Preparation of inactivated sendai virus vaccine - Google Patents
Preparation of inactivated sendai virus vaccineInfo
- Publication number
- JPS5795917A JPS5795917A JP17179580A JP17179580A JPS5795917A JP S5795917 A JPS5795917 A JP S5795917A JP 17179580 A JP17179580 A JP 17179580A JP 17179580 A JP17179580 A JP 17179580A JP S5795917 A JPS5795917 A JP S5795917A
- Authority
- JP
- Japan
- Prior art keywords
- sendai virus
- hvj
- water
- pellet
- mole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000711408 Murine respirovirus Species 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000008188 pellet Substances 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 229920001213 Polysorbate 20 Polymers 0.000 abstract 1
- 241000283984 Rodentia Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PURPOSE: To prepare titled safe and effective vaccine useful for preventing the infection with Sendai virus, by treating the pellet of Sendai virus with a nonionic surface-active agent and an organic solvent which is not completely miscible with water, in the absence of salts.
CONSTITUTION: The pellet of Sendai virus (another name: Hemagglutionating Virus of Japan; abbr. HVJ) is treated with a nonionic surface-active agent (e.g. polyoxyethylene sorbitan monolaurate) and an organic solvent (e.g. ethyl ether) which is not completely miscible with water, essentially in the absence of salts (e.g. physiological sline water, buffer solutions, etc; the concentration of salt is <1m-mole, pref.<0.5m-mole) to obtain the objective inactivated HVJ vaccine. In has high immunity titer and low toxicity, and can be inoculated safely to mammalians (e.g. rodents such as mouse) having sensitivity to HVJ.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17179580A JPS5795917A (en) | 1980-12-04 | 1980-12-04 | Preparation of inactivated sendai virus vaccine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17179580A JPS5795917A (en) | 1980-12-04 | 1980-12-04 | Preparation of inactivated sendai virus vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5795917A true JPS5795917A (en) | 1982-06-15 |
Family
ID=15929832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17179580A Pending JPS5795917A (en) | 1980-12-04 | 1980-12-04 | Preparation of inactivated sendai virus vaccine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5795917A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554158A (en) * | 1983-04-07 | 1985-11-19 | Simonsen Laboratories, Inc. | Modified live sendai virus vaccine for administering through an aerosol and method of producing the same |
| WO2005120579A1 (en) * | 2004-06-14 | 2005-12-22 | Ishihara Sangyo Kaisha, Ltd. | Freeze-dried composition of inactivated virus envelope with membrane fusion activity |
| US12258540B2 (en) | 2017-10-30 | 2025-03-25 | Takeda Pharmaceutical Company Limited | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
-
1980
- 1980-12-04 JP JP17179580A patent/JPS5795917A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4554158A (en) * | 1983-04-07 | 1985-11-19 | Simonsen Laboratories, Inc. | Modified live sendai virus vaccine for administering through an aerosol and method of producing the same |
| WO2005120579A1 (en) * | 2004-06-14 | 2005-12-22 | Ishihara Sangyo Kaisha, Ltd. | Freeze-dried composition of inactivated virus envelope with membrane fusion activity |
| US20080102524A1 (en) * | 2004-06-14 | 2008-05-01 | Ishihara Sangyo Kaisha, Ltd. | Freeze-Dried Composition of Inactivated Virus Envelope with Membrane Fusion Activity |
| US8043610B2 (en) | 2004-06-14 | 2011-10-25 | Ishihara Sangyo Kaisha, Ltd. | Freeze-dried composition of inactivated virus envelope with membrane fusion activity |
| US12258540B2 (en) | 2017-10-30 | 2025-03-25 | Takeda Pharmaceutical Company Limited | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
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