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JPS5794295A - Preparation of optically active ester and/or acid - Google Patents

Preparation of optically active ester and/or acid

Info

Publication number
JPS5794295A
JPS5794295A JP17029580A JP17029580A JPS5794295A JP S5794295 A JPS5794295 A JP S5794295A JP 17029580 A JP17029580 A JP 17029580A JP 17029580 A JP17029580 A JP 17029580A JP S5794295 A JPS5794295 A JP S5794295A
Authority
JP
Japan
Prior art keywords
ester
acid
optically active
enzyme
active ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17029580A
Other languages
Japanese (ja)
Other versions
JPH0160239B2 (en
Inventor
Shinobu Iriuchijima
Natsuko Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP17029580A priority Critical patent/JPS5794295A/en
Publication of JPS5794295A publication Critical patent/JPS5794295A/en
Publication of JPH0160239B2 publication Critical patent/JPH0160239B2/ja
Granted legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare an optically active ester (and/or acid), with simple means, by the asymmetric hydrolysis of an ester having asymmetric carbon atom with a specific enzyme (or microorganism).
CONSTITUTION: An optically active ester and/or acid can be prepared by using an enzyme[e.g. "Lipase MY" (product of Meito Sangyo KK)]or microorganism (e.g. Rhizopus delemar IAM6019) capable of asymmetrically hydrolyzing an ester. To be concrete, an optically active compound is prepared by adding the above enzyme, etc. to an ester of formula[R is alkyl; R' is (substituted) alkyl or aryl; X is halogen], carrying out the asymmetric hydrolysis of the ester at about 10W50°C for several hoursWseveral days keeping the pH of the reaction mixture at about 4W7.5 pref. with sodium phosphate buffer solution, etc., and separating the remaining ester and acid by conventional means.
COPYRIGHT: (C)1982,JPO&Japio
JP17029580A 1980-12-04 1980-12-04 Preparation of optically active ester and/or acid Granted JPS5794295A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17029580A JPS5794295A (en) 1980-12-04 1980-12-04 Preparation of optically active ester and/or acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17029580A JPS5794295A (en) 1980-12-04 1980-12-04 Preparation of optically active ester and/or acid

Publications (2)

Publication Number Publication Date
JPS5794295A true JPS5794295A (en) 1982-06-11
JPH0160239B2 JPH0160239B2 (en) 1989-12-21

Family

ID=15902308

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17029580A Granted JPS5794295A (en) 1980-12-04 1980-12-04 Preparation of optically active ester and/or acid

Country Status (1)

Country Link
JP (1) JPS5794295A (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130752A2 (en) * 1983-07-04 1985-01-09 Mitsubishi Rayon Co., Ltd. Process for preparing optically active carboxylic acids and antipode esters thereof
WO1985003307A1 (en) * 1984-01-23 1985-08-01 Wisconsin Alumni Research Foundation Process for preparing optically-active 4-amino-3-hydroxybutyric acid
US4601987A (en) * 1985-02-27 1986-07-22 Massachusetts Institute Of Technology Enzymatic production of optical isomers of 2-halopropionic acids
US4668628A (en) * 1985-04-01 1987-05-26 Stauffer Chemical Company Resolution of racemic mixtures of aliphatic acid esters
JPS62190097A (en) * 1985-12-20 1987-08-20 ウイスコンシン・アルムナイ・リサ−チ・フアウンデイシヨン Production of (s)-alpha-methylaryl acetate
US4923810A (en) * 1988-08-24 1990-05-08 Genzyme Corporation Resolution of glycidyl esters to high enantiomeric excess
US5037747A (en) * 1988-01-26 1991-08-06 Hoffmann-La Roche Inc. Production of benzopyran-2-carboxylic acids and esters by enzymatic hydrolysis
US5061629A (en) * 1988-01-26 1991-10-29 Hoffman-La Roche Inc. Production of 2-hydroxy substituted arylalkanoic acids and esters by enzymatic hydrolysis
US5223432A (en) * 1990-09-12 1993-06-29 Hoffmann-La Roche Inc. Process for preparing optically pure (S)-α-((tert-butylsulfonyl)methyl)hydrocinnamic acid using protease
US5248601A (en) * 1986-03-14 1993-09-28 Franco Francalanci Process for preparing L(-)-carnitine chloride
US5753495A (en) * 1993-08-23 1998-05-19 Basf Aktiengesellschaft Process for the preparation of (L)-2-chloropropionic acid and its salts using lipase from pseudomonas

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2524744Y2 (en) * 1991-08-30 1997-02-05 積水化成品工業株式会社 Adhesive label

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130752A2 (en) * 1983-07-04 1985-01-09 Mitsubishi Rayon Co., Ltd. Process for preparing optically active carboxylic acids and antipode esters thereof
WO1985003307A1 (en) * 1984-01-23 1985-08-01 Wisconsin Alumni Research Foundation Process for preparing optically-active 4-amino-3-hydroxybutyric acid
US4584270A (en) * 1984-01-23 1986-04-22 Wisconsin Alumni Research Foundation Process for preparing optically-active 4-amino-3-hydroxybutyric acid
US4601987A (en) * 1985-02-27 1986-07-22 Massachusetts Institute Of Technology Enzymatic production of optical isomers of 2-halopropionic acids
US4668628A (en) * 1985-04-01 1987-05-26 Stauffer Chemical Company Resolution of racemic mixtures of aliphatic acid esters
JPS62190097A (en) * 1985-12-20 1987-08-20 ウイスコンシン・アルムナイ・リサ−チ・フアウンデイシヨン Production of (s)-alpha-methylaryl acetate
JP2509200B2 (en) * 1985-12-20 1996-06-19 ウイスコンシン・アルムナイ・リサ−チ・フアウンデイシヨン Method for producing (S) -α-methylarylacetic acid
US5248601A (en) * 1986-03-14 1993-09-28 Franco Francalanci Process for preparing L(-)-carnitine chloride
US5037747A (en) * 1988-01-26 1991-08-06 Hoffmann-La Roche Inc. Production of benzopyran-2-carboxylic acids and esters by enzymatic hydrolysis
US5061629A (en) * 1988-01-26 1991-10-29 Hoffman-La Roche Inc. Production of 2-hydroxy substituted arylalkanoic acids and esters by enzymatic hydrolysis
US4923810A (en) * 1988-08-24 1990-05-08 Genzyme Corporation Resolution of glycidyl esters to high enantiomeric excess
US5223432A (en) * 1990-09-12 1993-06-29 Hoffmann-La Roche Inc. Process for preparing optically pure (S)-α-((tert-butylsulfonyl)methyl)hydrocinnamic acid using protease
US5753495A (en) * 1993-08-23 1998-05-19 Basf Aktiengesellschaft Process for the preparation of (L)-2-chloropropionic acid and its salts using lipase from pseudomonas

Also Published As

Publication number Publication date
JPH0160239B2 (en) 1989-12-21

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