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JPS5728064A - Phthalazinone derivative - Google Patents

Phthalazinone derivative

Info

Publication number
JPS5728064A
JPS5728064A JP10538980A JP10538980A JPS5728064A JP S5728064 A JPS5728064 A JP S5728064A JP 10538980 A JP10538980 A JP 10538980A JP 10538980 A JP10538980 A JP 10538980A JP S5728064 A JPS5728064 A JP S5728064A
Authority
JP
Japan
Prior art keywords
formula
ulcer
gastric
derivative expressed
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10538980A
Other languages
Japanese (ja)
Other versions
JPS6338996B2 (en
Inventor
Toshihiro Yamada
Yoichi Nobuhara
Hiroshi Shimamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MORISHITA SEIYAKU KK
Morishita Pharmaceuticals Co Ltd
Original Assignee
MORISHITA SEIYAKU KK
Morishita Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MORISHITA SEIYAKU KK, Morishita Pharmaceuticals Co Ltd filed Critical MORISHITA SEIYAKU KK
Priority to JP10538980A priority Critical patent/JPS5728064A/en
Publication of JPS5728064A publication Critical patent/JPS5728064A/en
Publication of JPS6338996B2 publication Critical patent/JPS6338996B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A phthalazinone derivative expressed by formula I (R1 is lower alkyl; Z is S or -CH2-; X is S or NH; m is an integer 1W3; n is 0, 1 or 2).
EXAMPLE: N-Cyano-S-methyl-N'-[ 3-( 1-oxo-4-phenyl-2-phthalazinyl )propyl ]isothiourea.
USE: A medicine, useful as a remedy and a preventing agent against peptic ulcers, e.g. gastric hyperacidity, gastric ulcer and duodenal ulcer, and capable of exhibiting the activity of inhibiting the gastric juice secretion and inhibiting the development of experimental ulcers, e.g. the aspirin, stress or Shay ulcer, with proloned action, weak toxicity and improved chemical resistance.
PROCESS: An amine derivative expressed by formula II is reacted with a dialkyl cyanodithioimidocarbonate derivative expressed by formula III (R2 is lower alkyl) in an amount corresponding to the reaction in the absence or presence of an inert solvent at room temperature or under cooling or refluxing of the solvent to give compound expressed by formula I in which X is S.
COPYRIGHT: (C)1982,JPO&Japio
JP10538980A 1980-07-29 1980-07-29 Phthalazinone derivative Granted JPS5728064A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10538980A JPS5728064A (en) 1980-07-29 1980-07-29 Phthalazinone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10538980A JPS5728064A (en) 1980-07-29 1980-07-29 Phthalazinone derivative

Publications (2)

Publication Number Publication Date
JPS5728064A true JPS5728064A (en) 1982-02-15
JPS6338996B2 JPS6338996B2 (en) 1988-08-03

Family

ID=14406288

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10538980A Granted JPS5728064A (en) 1980-07-29 1980-07-29 Phthalazinone derivative

Country Status (1)

Country Link
JP (1) JPS5728064A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0309765A2 (en) * 1987-09-30 1989-04-05 Fisons Corporation 1(2H)-Phthalazinones as cytoprotective agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0309765A2 (en) * 1987-09-30 1989-04-05 Fisons Corporation 1(2H)-Phthalazinones as cytoprotective agents
EP0309765A3 (en) * 1987-09-30 1990-09-26 Fisons Corporation 1(2h)-phthalazinones as cytoprotective agents

Also Published As

Publication number Publication date
JPS6338996B2 (en) 1988-08-03

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