JPS57193456A - Novel amidinopiperidine derivative and its preparation - Google Patents
Novel amidinopiperidine derivative and its preparationInfo
- Publication number
- JPS57193456A JPS57193456A JP7814381A JP7814381A JPS57193456A JP S57193456 A JPS57193456 A JP S57193456A JP 7814381 A JP7814381 A JP 7814381A JP 7814381 A JP7814381 A JP 7814381A JP S57193456 A JPS57193456 A JP S57193456A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- amidinopiperidine
- formulai
- expressed
- substituent group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QUUYRYYUKNNNNS-UHFFFAOYSA-N piperidine-1-carboximidamide Chemical class NC(=N)N1CCCCC1 QUUYRYYUKNNNNS-UHFFFAOYSA-N 0.000 title abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- YTKMPUUPNPIZBX-UHFFFAOYSA-N 2-(1-carbamimidoylpiperidin-4-yl)acetic acid Chemical compound NC(=N)N1CCC(CC(O)=O)CC1 YTKMPUUPNPIZBX-UHFFFAOYSA-N 0.000 abstract 1
- 108090000317 Chymotrypsin Proteins 0.000 abstract 1
- 108010028774 Complement C1 Proteins 0.000 abstract 1
- 102100025406 Complement C1s subcomponent Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 102000001399 Kallikrein Human genes 0.000 abstract 1
- 108060005987 Kallikrein Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical class OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229960002376 chymotrypsin Drugs 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
- 150000003672 ureas Chemical class 0.000 abstract 1
- 229960005356 urokinase Drugs 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An amidinopiperidine derivative expressed by formulaI (R is H or phenyl which may have a substituent group; n is an integer 1W3) and an acid addition salt thereof.
EXAMPLE: N-Amidinopiperidine-4-acetic acid.
USE: Improved inhibitory action on proteolytic enzymes, e.g. trypsin, chymotrypsin, callicrein or urokinase, and recognized powerful inhibitory action on C1 esterase which is an activating enzyme of a complement.
PROCESS: A piperidine derivative expressed by formula II is reacted with a urea derivative expressed by formula III (X is alkoxy or alkylthio) or a salt thereof to give the compound expressed by formulaI(R is H), which is then reacted with a phenol of the formula R'-OH (R' is phenyl which may have a substituent group) which may have the substituent group or a sulfite derivative thereof to afford th compound expressed by formulaI(R is R').
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7814381A JPS57193456A (en) | 1981-05-25 | 1981-05-25 | Novel amidinopiperidine derivative and its preparation |
| US06/379,714 US4433152A (en) | 1981-05-25 | 1982-05-19 | Amidinopiperidine derivatives |
| CA000403483A CA1188302A (en) | 1981-05-25 | 1982-05-21 | Amidinopiperidine derivatives and a process for producing the same |
| AR82289478A AR242560A1 (en) | 1981-05-25 | 1982-05-21 | A procedure for the production of 1-amidine-piperidine -alkanoic acids and their pharmaceutically acceptable salts. |
| CH3188/82A CH654298A5 (en) | 1981-05-25 | 1982-05-24 | AMIDINOPIPERIDINE DERIVATIVES AND THEIR MANUFACTURING PROCESS. |
| NL8202109A NL8202109A (en) | 1981-05-25 | 1982-05-24 | NEW AMIDINOPIPERIDINE DERIVATIVES AND METHODS FOR PREPARING AND USING THESE DERIVATIVES. |
| IT67668/82A IT1157014B (en) | 1981-05-25 | 1982-05-24 | DERIVATIVES OF AMIDINOPIPERIDINE PARTICULARLY USEFUL AS MEDICATIONS AND PROCEDURE FOR THEIR PRODUCTION |
| GB08215069A GB2101125B (en) | 1981-05-25 | 1982-05-24 | Novel amidinopiperidine derivatives and processes for producing them |
| BR8203060A BR8203060A (en) | 1981-05-25 | 1982-05-25 | PROCESS FOR THE PRODUCTION OF AMINOPIPERIDINE DERIVATIVES |
| KR8202310A KR880002273B1 (en) | 1981-05-25 | 1982-05-25 | Method for preparing amidino piperidine derivative |
| MX192853A MX158198A (en) | 1981-05-25 | 1982-05-25 | PROCEDURE FOR PREPARING AMIDINOPIPERIDINE DERIVATIVES |
| FR8209056A FR2506306B1 (en) | 1981-05-25 | 1982-05-25 | NOVEL AMIDINOPIPERIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION |
| ES512519A ES512519A0 (en) | 1981-05-25 | 1982-05-25 | MANUFACTURING PROCESS OF THE NEW DERIVATIVES OF AMIDINOPIPERADINE. |
| DE19823219614 DE3219614A1 (en) | 1981-05-25 | 1982-05-25 | AMIDINOPIPERIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7814381A JPS57193456A (en) | 1981-05-25 | 1981-05-25 | Novel amidinopiperidine derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57193456A true JPS57193456A (en) | 1982-11-27 |
| JPH0160018B2 JPH0160018B2 (en) | 1989-12-20 |
Family
ID=13653657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7814381A Granted JPS57193456A (en) | 1981-05-25 | 1981-05-25 | Novel amidinopiperidine derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57193456A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998015531A1 (en) * | 1996-10-07 | 1998-04-16 | Koei Chemical Co., Ltd. | PROCESS FOR PREPARING ACID SALTS OF η-(PIPERIDYL)BUTYRIC ACID |
-
1981
- 1981-05-25 JP JP7814381A patent/JPS57193456A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998015531A1 (en) * | 1996-10-07 | 1998-04-16 | Koei Chemical Co., Ltd. | PROCESS FOR PREPARING ACID SALTS OF η-(PIPERIDYL)BUTYRIC ACID |
| US6197961B1 (en) | 1996-10-07 | 2001-03-06 | Koei Chemical Co., Ltd. | Process for preparing acid salts of γ-(piperidyl)butyric acid |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0160018B2 (en) | 1989-12-20 |
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