JPS57192399A - Composition containing s-adenosyl-l-methionine and its preparation - Google Patents
Composition containing s-adenosyl-l-methionine and its preparationInfo
- Publication number
- JPS57192399A JPS57192399A JP7554181A JP7554181A JPS57192399A JP S57192399 A JPS57192399 A JP S57192399A JP 7554181 A JP7554181 A JP 7554181A JP 7554181 A JP7554181 A JP 7554181A JP S57192399 A JPS57192399 A JP S57192399A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- maltose
- adenosyl
- methionine
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 title abstract 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 abstract 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 229940071870 hydroiodic acid Drugs 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000001291 vacuum drying Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE: S-Adenosyl-L-methionine, a protonic acid and maltose are used as the components of the composition to give the titled composition which has high storage stability and high safety to living body and is used as a remedy for diseases caused by metabolism disorders of various kinds.
CONSTITUTION: An aqueous medium solution containing 1pt. of S-adenosyl-L- methionine (SAM), 0.5W4pts. of protonic acid such as hydrobromic, hydrochloric or hydroiodic acid and less than 10pts. of maltose is heated to evaporate the aqueous solvent up to dryness to give a composition containing SAM. The reaction temperature is lower than 50°C, preferably lower than 35°C and the evaporation is effected suitably by the freeze drying method or vacuum drying one. The resultant composition is a crystal-like powder and shows high stability under dried conditions of less than 1% water content even at room temperature for a long period of time.
EFFECT: Maltose as a starting material is extremely safe, inexpensive and readily available, so the composition has high productivity in a practical scale.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7554181A JPS57192399A (en) | 1981-05-18 | 1981-05-18 | Composition containing s-adenosyl-l-methionine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7554181A JPS57192399A (en) | 1981-05-18 | 1981-05-18 | Composition containing s-adenosyl-l-methionine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57192399A true JPS57192399A (en) | 1982-11-26 |
Family
ID=13579160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7554181A Pending JPS57192399A (en) | 1981-05-18 | 1981-05-18 | Composition containing s-adenosyl-l-methionine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57192399A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4465672A (en) * | 1981-08-24 | 1984-08-14 | Bioresearch S.P.A. | Stable S-adenosylmethionine salts, the process for their preparation, and therapeutic compositions which contain them as active principle |
| US4543408A (en) * | 1981-08-24 | 1985-09-24 | Bioresearch S.P.A. | Stable S-adenosylmethionine salts, the process for their preparation, and therapeutic compositions which contain them as active principle |
-
1981
- 1981-05-18 JP JP7554181A patent/JPS57192399A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4465672A (en) * | 1981-08-24 | 1984-08-14 | Bioresearch S.P.A. | Stable S-adenosylmethionine salts, the process for their preparation, and therapeutic compositions which contain them as active principle |
| US4543408A (en) * | 1981-08-24 | 1985-09-24 | Bioresearch S.P.A. | Stable S-adenosylmethionine salts, the process for their preparation, and therapeutic compositions which contain them as active principle |
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