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JPS57192348A - Decaprenyl-substituted amino acid derivative - Google Patents

Decaprenyl-substituted amino acid derivative

Info

Publication number
JPS57192348A
JPS57192348A JP7615981A JP7615981A JPS57192348A JP S57192348 A JPS57192348 A JP S57192348A JP 7615981 A JP7615981 A JP 7615981A JP 7615981 A JP7615981 A JP 7615981A JP S57192348 A JPS57192348 A JP S57192348A
Authority
JP
Japan
Prior art keywords
compound
amino acid
reaction
formula
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7615981A
Other languages
Japanese (ja)
Other versions
JPH0143733B2 (en
Inventor
Yoshiyuki Tawara
Yasuhiro Komatsu
Hiroyasu Koyama
Reiko Kubota
Teruto Yamaguchi
Toshihiro Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Priority to JP7615981A priority Critical patent/JPS57192348A/en
Publication of JPS57192348A publication Critical patent/JPS57192348A/en
Publication of JPH0143733B2 publication Critical patent/JPH0143733B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:The compound of formulaI(A is -CH2CO- or -NH-; R is residue of alanine, phenylalanine, or alanylglutamic acid) and its acid addition salt.
EXAMPLE: N-Decaprenylacetyl-L-alanine.
USE: Antiviral agent. It has interferon-inducing activity, and exhibits excellent antiviral effect and antitumor effect by animal experiments.
PROCESS: The compound of formulaIcan be prepared by the conventional peptide-bond forming reaction of decaprenylacetic acid of formula II or decaprenylamine of formula III. For example, the compound of formulaIis obtained by the carbodiimide process comprising the reaction of the compound of formula II with an N-protected amino acid or the amine of formula III with an amino acid ester in the presence of a dehydration agent (e.g. DCC). The reaction is preferably carried out in an organic solvent (e.g. acetonitrile) at 0°CW room temperature.
COPYRIGHT: (C)1982,JPO&Japio
JP7615981A 1981-05-18 1981-05-18 Decaprenyl-substituted amino acid derivative Granted JPS57192348A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7615981A JPS57192348A (en) 1981-05-18 1981-05-18 Decaprenyl-substituted amino acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7615981A JPS57192348A (en) 1981-05-18 1981-05-18 Decaprenyl-substituted amino acid derivative

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP63316275A Division JPH02144A (en) 1988-12-16 1988-12-16 Decaprenyl-substituted amino acid derivative and antiviral agent

Publications (2)

Publication Number Publication Date
JPS57192348A true JPS57192348A (en) 1982-11-26
JPH0143733B2 JPH0143733B2 (en) 1989-09-22

Family

ID=13597267

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7615981A Granted JPS57192348A (en) 1981-05-18 1981-05-18 Decaprenyl-substituted amino acid derivative

Country Status (1)

Country Link
JP (1) JPS57192348A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0119500A2 (en) * 1983-02-21 1984-09-26 Nisshin Flour Milling Co., Ltd. Novel isoprenylic acid amide derivatives, processes for their preparation and pharmaceutical compositions containing them
EP0194901A2 (en) * 1985-03-15 1986-09-17 Shionogi & Co., Ltd. Isoprenoidamine derivatives, compositions containing them, their preparation, and their use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0119500A2 (en) * 1983-02-21 1984-09-26 Nisshin Flour Milling Co., Ltd. Novel isoprenylic acid amide derivatives, processes for their preparation and pharmaceutical compositions containing them
EP0194901A2 (en) * 1985-03-15 1986-09-17 Shionogi & Co., Ltd. Isoprenoidamine derivatives, compositions containing them, their preparation, and their use
US4900749A (en) * 1985-03-15 1990-02-13 Shionogi & Co., Ltd. Isoprenoidamine compounds useful as antiulcer agents

Also Published As

Publication number Publication date
JPH0143733B2 (en) 1989-09-22

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