JPS57185220A - Carcinostatic agent containing chlorophyll derivative as active component - Google Patents
Carcinostatic agent containing chlorophyll derivative as active componentInfo
- Publication number
- JPS57185220A JPS57185220A JP6759381A JP6759381A JPS57185220A JP S57185220 A JPS57185220 A JP S57185220A JP 6759381 A JP6759381 A JP 6759381A JP 6759381 A JP6759381 A JP 6759381A JP S57185220 A JPS57185220 A JP S57185220A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- active component
- chlorophyll derivative
- tumor cells
- chlorophyll
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To provide a carcinostatic agent containing a chlorophyll derivative as an active component, and capable of killing the cancer cells remarkably and selectively by the radiation of visible light having a specific wavelength.
CONSTITUTION: The objective agent contains the chlorophyll derivative of formula[X is H or OH; Y is -COOCH3 or H; Z is Mg or two H atoms (at 13 and 14 positions)], as an active component. When the chlorophyll derivative is administered to an animal, it is accumulated in tumor cells in preference to the normal cells and discharged slowly from the tumor cells. It remarkably suppresses the proliferation of the tumor cells under irradiation with visible light having a wavelength of 400W700nm, and kills the tumor cells. On the other hand, the derivative is rapidly discharged from normal cells, and completely unreactive and harmless in the dark. the chlorophyll derivative can be prepared e.g. by removing the phytyl group from chlorophyll of a green plant (e.g. chlorella)with chlorophyllase in the cell and oxidizing the product with an oxidase.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6759381A JPS57185220A (en) | 1981-05-07 | 1981-05-07 | Carcinostatic agent containing chlorophyll derivative as active component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6759381A JPS57185220A (en) | 1981-05-07 | 1981-05-07 | Carcinostatic agent containing chlorophyll derivative as active component |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57185220A true JPS57185220A (en) | 1982-11-15 |
| JPS634805B2 JPS634805B2 (en) | 1988-02-01 |
Family
ID=13349354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6759381A Granted JPS57185220A (en) | 1981-05-07 | 1981-05-07 | Carcinostatic agent containing chlorophyll derivative as active component |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57185220A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS617279A (en) * | 1984-06-22 | 1986-01-13 | Toyo Hatsuka Kogyo Kk | Phaeophorbide derivative and its alkali salt |
| JPS6183185A (en) * | 1984-10-01 | 1986-04-26 | Toyo Hatsuka Kogyo Kk | Metal phephorbide derivative and metal porphyrin derivative |
| JPS625912A (en) * | 1985-04-30 | 1987-01-12 | Nippon Petrochem Co Ltd | Novel tetrapyrrole pharmaceutical composition |
| JPS63239286A (en) * | 1986-08-26 | 1988-10-05 | Advance Res & Dev Co Ltd | Novel pheophorbide derivative and tumor diagnostic agent |
| US5051415A (en) * | 1986-01-02 | 1991-09-24 | The University Of Toledo | Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| US5216012A (en) * | 1986-01-02 | 1993-06-01 | University Of Toledo | Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| JPH0696721B2 (en) * | 1986-12-08 | 1994-11-30 | ザ ダウ ケミカル カンパニー | Method for densifying metal preform |
| US5534506A (en) * | 1986-01-02 | 1996-07-09 | University Of Toledo | Use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| US6454789B1 (en) | 1999-01-15 | 2002-09-24 | Light Science Corporation | Patient portable device for photodynamic therapy |
| US6602274B1 (en) | 1999-01-15 | 2003-08-05 | Light Sciences Corporation | Targeted transcutaneous cancer therapy |
-
1981
- 1981-05-07 JP JP6759381A patent/JPS57185220A/en active Granted
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS617279A (en) * | 1984-06-22 | 1986-01-13 | Toyo Hatsuka Kogyo Kk | Phaeophorbide derivative and its alkali salt |
| US4709022A (en) * | 1984-06-22 | 1987-11-24 | Isao Sakata | Pheophorbide derivatives and alkaline salts thereof |
| JPS6183185A (en) * | 1984-10-01 | 1986-04-26 | Toyo Hatsuka Kogyo Kk | Metal phephorbide derivative and metal porphyrin derivative |
| JPS625912A (en) * | 1985-04-30 | 1987-01-12 | Nippon Petrochem Co Ltd | Novel tetrapyrrole pharmaceutical composition |
| US5051415A (en) * | 1986-01-02 | 1991-09-24 | The University Of Toledo | Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| US5216012A (en) * | 1986-01-02 | 1993-06-01 | University Of Toledo | Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| US5534506A (en) * | 1986-01-02 | 1996-07-09 | University Of Toledo | Use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| JPS63239286A (en) * | 1986-08-26 | 1988-10-05 | Advance Res & Dev Co Ltd | Novel pheophorbide derivative and tumor diagnostic agent |
| JPH0696721B2 (en) * | 1986-12-08 | 1994-11-30 | ザ ダウ ケミカル カンパニー | Method for densifying metal preform |
| US6454789B1 (en) | 1999-01-15 | 2002-09-24 | Light Science Corporation | Patient portable device for photodynamic therapy |
| US6602274B1 (en) | 1999-01-15 | 2003-08-05 | Light Sciences Corporation | Targeted transcutaneous cancer therapy |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS634805B2 (en) | 1988-02-01 |
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