JPS57175127A - Substance and vaccine related to hepatitis nanb-1 and nanb-2 viral antigen - Google Patents
Substance and vaccine related to hepatitis nanb-1 and nanb-2 viral antigenInfo
- Publication number
- JPS57175127A JPS57175127A JP6022181A JP6022181A JPS57175127A JP S57175127 A JPS57175127 A JP S57175127A JP 6022181 A JP6022181 A JP 6022181A JP 6022181 A JP6022181 A JP 6022181A JP S57175127 A JPS57175127 A JP S57175127A
- Authority
- JP
- Japan
- Prior art keywords
- nanb
- hepatitis
- viral
- vaccine
- hepatitis nanb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000006454 hepatitis Diseases 0.000 title abstract 9
- 231100000283 hepatitis Toxicity 0.000 title abstract 9
- 230000003612 virological effect Effects 0.000 title abstract 5
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 229960004854 viral vaccine Drugs 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000004523 agglutinating effect Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PURPOSE: To obtain the titled vaccine, having a high immunogenicity without infection, and useful for a detecting reagent of the titled viral antigen, by treating hepatitis NANB-1 and NANB-2 viral particles with an organic solvent, and heat-treating the particles.
CONSTITUTION: Viral particles, obtained from the blood serum of the hepatitis NANB-1 in the acute stadium, and found to be capable of agglutinating with the hepatitis NANB-1 blood serum in the decubation and infecting and developing the typical hepatitis NANB-1 in sensitive animals are inactivated by the addition of an organic solvent, e.g. 37% formalin, and the heat-treatment (60°C for 10hr) to give a hepatitis NANB-1 viral vaccine. Similarly, the hepatitis NANB-2 viral vaccine is obtained. The resultant respective specific antibodies of the hepatitic viruses permit the detection of the new hepatitis NANB-1 and NANB-2 viral antigens capable of infecting and developing the hepatitis non-A and non-B.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6022181A JPS57175127A (en) | 1981-04-21 | 1981-04-21 | Substance and vaccine related to hepatitis nanb-1 and nanb-2 viral antigen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6022181A JPS57175127A (en) | 1981-04-21 | 1981-04-21 | Substance and vaccine related to hepatitis nanb-1 and nanb-2 viral antigen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57175127A true JPS57175127A (en) | 1982-10-28 |
| JPH0369892B2 JPH0369892B2 (en) | 1991-11-05 |
Family
ID=13135884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6022181A Granted JPS57175127A (en) | 1981-04-21 | 1981-04-21 | Substance and vaccine related to hepatitis nanb-1 and nanb-2 viral antigen |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57175127A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4702909A (en) * | 1982-05-05 | 1987-10-27 | Louisiana State University A & M | Non-A, non-B hepatitis antigen, antigen compositions, vaccine and diagnostic reagent |
| US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| US7838006B2 (en) | 2000-08-24 | 2010-11-23 | Immunitor Usa Inc. | Viral vaccine composition, process and methods of use |
| US9974847B2 (en) | 2000-08-24 | 2018-05-22 | Immunitor USA, Inc. | Treatment and prevention of tuberculosis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55122156A (en) * | 1979-03-14 | 1980-09-19 | Chemo Sero Therapeut Res Inst | C-type hepatitis virus-associated antigen |
-
1981
- 1981-04-21 JP JP6022181A patent/JPS57175127A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55122156A (en) * | 1979-03-14 | 1980-09-19 | Chemo Sero Therapeut Res Inst | C-type hepatitis virus-associated antigen |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4702909A (en) * | 1982-05-05 | 1987-10-27 | Louisiana State University A & M | Non-A, non-B hepatitis antigen, antigen compositions, vaccine and diagnostic reagent |
| US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| US7838006B2 (en) | 2000-08-24 | 2010-11-23 | Immunitor Usa Inc. | Viral vaccine composition, process and methods of use |
| US9974847B2 (en) | 2000-08-24 | 2018-05-22 | Immunitor USA, Inc. | Treatment and prevention of tuberculosis |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0369892B2 (en) | 1991-11-05 |
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