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JPS57156467A - 2,4-disubstituted-6-quinazolinesulfonamide derivative - Google Patents

2,4-disubstituted-6-quinazolinesulfonamide derivative

Info

Publication number
JPS57156467A
JPS57156467A JP56039551A JP3955181A JPS57156467A JP S57156467 A JPS57156467 A JP S57156467A JP 56039551 A JP56039551 A JP 56039551A JP 3955181 A JP3955181 A JP 3955181A JP S57156467 A JPS57156467 A JP S57156467A
Authority
JP
Japan
Prior art keywords
amino
formula
expressed
compound expressed
quinazolinesulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56039551A
Other languages
Japanese (ja)
Other versions
JPH0254344B2 (en
Inventor
Hiroyoshi Hidaka
Takanori Sone
Taiji Sasaki
Tasuke Sugihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Priority to JP56039551A priority Critical patent/JPS57156467A/en
Publication of JPS57156467A publication Critical patent/JPS57156467A/en
Publication of JPH0254344B2 publication Critical patent/JPH0254344B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formulaI[R1 is Cl, amino, alkoxyl or piperidino; R2 is amino or piperidino; R2 is formula IV (R4 is lower alkyl), -NH(CH2)nNH2 (n is an integer 4W10) or formula V]and an acid addition salt thereof.
EXAMPLE: 1-( 4-Amino-2-chloro-6-quinazolinesulfonyl )-4-( 2-ethoxy-2-phenylethyl ) piperazine.
USE: A vasodilator, ameliorant of cerebral circulation, remedy for angina pectoris and a preventing agent and remedy for the cerebral and cardiovascular thrombosis having powerful smooth muscle relaxing action and inhibitory action on blood platelet aggregation.
PROCESS: A 4-amino-2-chloroquinazoline expressed by formula II is sulfonated and converted into an acid chloride. The resultant 4-amino-2-chloro-6-quinazolinesulfonyl chloride expressed by formula III is then reacted with a compound expressed by the formula R3H, e.g. 1-(2-ethoxy-2-phenylethyl)piperazine, to give the compound expressed by formulaI(R1 is Cl).
COPYRIGHT: (C)1982,JPO&Japio
JP56039551A 1981-03-20 1981-03-20 2,4-disubstituted-6-quinazolinesulfonamide derivative Granted JPS57156467A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56039551A JPS57156467A (en) 1981-03-20 1981-03-20 2,4-disubstituted-6-quinazolinesulfonamide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56039551A JPS57156467A (en) 1981-03-20 1981-03-20 2,4-disubstituted-6-quinazolinesulfonamide derivative

Publications (2)

Publication Number Publication Date
JPS57156467A true JPS57156467A (en) 1982-09-27
JPH0254344B2 JPH0254344B2 (en) 1990-11-21

Family

ID=12556192

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56039551A Granted JPS57156467A (en) 1981-03-20 1981-03-20 2,4-disubstituted-6-quinazolinesulfonamide derivative

Country Status (1)

Country Link
JP (1) JPS57156467A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4502880A (en) * 1983-02-03 1985-03-05 E. I. Du Pont De Nemours And Company 4-Pyridinium quinazoline derivatives
US4607034A (en) * 1979-10-29 1986-08-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinazoline derivatives and pharmaceutical composition thereof
US5430148A (en) * 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5050390A (en) * 1973-09-06 1975-05-06 Ciba Geigy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5050390A (en) * 1973-09-06 1975-05-06 Ciba Geigy

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4607034A (en) * 1979-10-29 1986-08-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Quinazoline derivatives and pharmaceutical composition thereof
US4502880A (en) * 1983-02-03 1985-03-05 E. I. Du Pont De Nemours And Company 4-Pyridinium quinazoline derivatives
US5430148A (en) * 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
US5707992A (en) * 1992-03-31 1998-01-13 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
US5885996A (en) * 1992-03-31 1999-03-23 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines

Also Published As

Publication number Publication date
JPH0254344B2 (en) 1990-11-21

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