JPS57144295A - Deoxynojirimycin-glucose oligomer and its preparation - Google Patents
Deoxynojirimycin-glucose oligomer and its preparationInfo
- Publication number
- JPS57144295A JPS57144295A JP2936081A JP2936081A JPS57144295A JP S57144295 A JPS57144295 A JP S57144295A JP 2936081 A JP2936081 A JP 2936081A JP 2936081 A JP2936081 A JP 2936081A JP S57144295 A JPS57144295 A JP S57144295A
- Authority
- JP
- Japan
- Prior art keywords
- deoxynojirimycin
- formula
- preparation
- compound
- compound expressed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008103 glucose Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000004382 Amylase Substances 0.000 abstract 2
- 102000013142 Amylases Human genes 0.000 abstract 2
- 108010065511 Amylases Proteins 0.000 abstract 2
- 229920002472 Starch Polymers 0.000 abstract 2
- 235000019418 amylase Nutrition 0.000 abstract 2
- 239000008107 starch Substances 0.000 abstract 2
- 235000019698 starch Nutrition 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 244000063299 Bacillus subtilis Species 0.000 abstract 1
- 235000014469 Bacillus subtilis Nutrition 0.000 abstract 1
- 229920001353 Dextrin Polymers 0.000 abstract 1
- 239000004375 Dextrin Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 239000013066 combination product Substances 0.000 abstract 1
- 229940127555 combination product Drugs 0.000 abstract 1
- 235000019425 dextrin Nutrition 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001542 oligosaccharide Polymers 0.000 abstract 1
- 150000002482 oligosaccharides Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by the formula (n is an integer 0W7).
EXAMPLE: 4-(α-D-Glucosyl)-deoxynojirimycin.
USE: A medicine having an amylase inhibitory action, and usable for diabetes, hyperlipemia, lipemia, etc.
PROCESS: A bacterial saccharifying amylase produced by Bacillus subtilis (ATCC 27505) is reacted with an α-1,4-combination product of glucose, e.g. starch, soluble starch, dextrin or oligosaccharide, in an aqueous medium, and the reaction product is then adsorbed in an ion exchange resin column, washed with water and eluted to give the compound expressed by the formula. The compound is then subjected to the column chromatography to isolate the respective components.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2936081A JPS57144295A (en) | 1981-03-03 | 1981-03-03 | Deoxynojirimycin-glucose oligomer and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2936081A JPS57144295A (en) | 1981-03-03 | 1981-03-03 | Deoxynojirimycin-glucose oligomer and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57144295A true JPS57144295A (en) | 1982-09-06 |
Family
ID=12274012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2936081A Pending JPS57144295A (en) | 1981-03-03 | 1981-03-03 | Deoxynojirimycin-glucose oligomer and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57144295A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
| US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
-
1981
- 1981-03-03 JP JP2936081A patent/JPS57144295A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
| US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
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