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JPS57134452A - N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the same - Google Patents

N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the same

Info

Publication number
JPS57134452A
JPS57134452A JP56019587A JP1958781A JPS57134452A JP S57134452 A JPS57134452 A JP S57134452A JP 56019587 A JP56019587 A JP 56019587A JP 1958781 A JP1958781 A JP 1958781A JP S57134452 A JPS57134452 A JP S57134452A
Authority
JP
Japan
Prior art keywords
compound
formula
amino acid
acidic amino
acid diamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56019587A
Other languages
Japanese (ja)
Other versions
JPS6352621B2 (en
Inventor
Noboru Takagawa
Yukitaka Hamaya
Takuya Kodama
Mariko Hayashi
Mutsuko Maekawa
Hinako Murota
Mariko Nakayama
Yasuyuki Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP56019587A priority Critical patent/JPS57134452A/en
Publication of JPS57134452A publication Critical patent/JPS57134452A/en
Publication of JPS6352621B2 publication Critical patent/JPS6352621B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:An N-acyl acidic amino acid diamide of formulaI(R1 and R3 are H or lower alkyl; R2 and R4 are lower alkyl; n is 1W3; R5 is OH or aryl, ar-(lower alkyl) or ar-(lower alkenyl) substituted with OH or lower alkoxy).
EXAMPLE: 2-( 2-Methoxybenzamido )-N5, N5-dimethyl-N1, N1-di-n-propylpentane- 1,5-diamide.
USE: Antiulcer agent useful for the remedy of human and animal ulcers. Dose: 10W 500mg/day for adult by oral administration.
PROCESS: The objective compound of formulaIis prepared by reacting the compound of formula II with the compound of formula R5COOH or its reactive derivative at the carboxyl group. The starting compound of formula II can be obtained by protecting the amino group of the compound of formula III, subjecting the compound to the dehydrative condensation with paraformaldehyde to obtain the compound of formula IV, reacting the compound with the amine of formula V or formula VI, and removing the protecting group.
COPYRIGHT: (C)1982,JPO&Japio
JP56019587A 1981-02-14 1981-02-14 N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the same Granted JPS57134452A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56019587A JPS57134452A (en) 1981-02-14 1981-02-14 N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56019587A JPS57134452A (en) 1981-02-14 1981-02-14 N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the same

Publications (2)

Publication Number Publication Date
JPS57134452A true JPS57134452A (en) 1982-08-19
JPS6352621B2 JPS6352621B2 (en) 1988-10-19

Family

ID=12003379

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56019587A Granted JPS57134452A (en) 1981-02-14 1981-02-14 N-acyl acidic amino acid diamide, its preparation, and antiulcer agent containing the same

Country Status (1)

Country Link
JP (1) JPS57134452A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227847A (en) * 1983-06-09 1984-12-21 Toyama Chem Co Ltd N-acyl acidic amino acid diamides, their production method, and antiulcer agents containing them
FR2565587A1 (en) * 1984-06-12 1985-12-13 Toyama Chemical Co Ltd NOVEL DERIVATIVE OF N-ACYLIC ACIDIC ACID AMINO ACID DIAMIDE, A SALT THEREOF, A PROCESS FOR PRODUCTION THEREOF AND AN ANTI-ULCEROUS AGENT CONTAINING THE SAME
EP0250148A2 (en) * 1986-06-16 1987-12-23 Merck & Co. Inc. Amino acid analogs as CCK-antagonists
WO1996026194A1 (en) * 1995-02-21 1996-08-29 Degussa Aktiengesellschaft Method of producing oxazolidinones, the use thereof and novel oxazolidinones
JP2009215268A (en) * 2008-03-12 2009-09-24 Shiseido Co Ltd Glutamic acid derivative, parakeratosis-suppressing agent, pore shrinking agent, rough skin preventing and ameliorating agent, and composition for external preparation for skin

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227847A (en) * 1983-06-09 1984-12-21 Toyama Chem Co Ltd N-acyl acidic amino acid diamides, their production method, and antiulcer agents containing them
JPH0460983B2 (en) * 1983-06-09 1992-09-29 Toyama Chemical Co Ltd
FR2565587A1 (en) * 1984-06-12 1985-12-13 Toyama Chemical Co Ltd NOVEL DERIVATIVE OF N-ACYLIC ACIDIC ACID AMINO ACID DIAMIDE, A SALT THEREOF, A PROCESS FOR PRODUCTION THEREOF AND AN ANTI-ULCEROUS AGENT CONTAINING THE SAME
EP0250148A2 (en) * 1986-06-16 1987-12-23 Merck & Co. Inc. Amino acid analogs as CCK-antagonists
WO1996026194A1 (en) * 1995-02-21 1996-08-29 Degussa Aktiengesellschaft Method of producing oxazolidinones, the use thereof and novel oxazolidinones
US6051715A (en) * 1995-02-21 2000-04-18 Degussa-Huls Ag Method of producing oxazolidinones, the use thereof and novel oxazolidinones
JP2009215268A (en) * 2008-03-12 2009-09-24 Shiseido Co Ltd Glutamic acid derivative, parakeratosis-suppressing agent, pore shrinking agent, rough skin preventing and ameliorating agent, and composition for external preparation for skin

Also Published As

Publication number Publication date
JPS6352621B2 (en) 1988-10-19

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