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JPS57126417A - Remedy for circulatory disease - Google Patents

Remedy for circulatory disease

Info

Publication number
JPS57126417A
JPS57126417A JP1020781A JP1020781A JPS57126417A JP S57126417 A JPS57126417 A JP S57126417A JP 1020781 A JP1020781 A JP 1020781A JP 1020781 A JP1020781 A JP 1020781A JP S57126417 A JPS57126417 A JP S57126417A
Authority
JP
Japan
Prior art keywords
phenoxy
converted
ethoxycarbonyloxy
remedy
nitratoethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1020781A
Other languages
Japanese (ja)
Other versions
JPH0143723B2 (en
Inventor
Shozo Shirato
Noboru Shimizu
Hiromichi Shigyo
Yoshinori Kyotani
Hisashi Kunieda
Kiyoshi Kawamura
Seiichi Sato
Toshihiro Akashi
Masahiko Nagakura
Hisatoshi Sawada
Yasuyoshi Uchida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Priority to JP1020781A priority Critical patent/JPS57126417A/en
Publication of JPS57126417A publication Critical patent/JPS57126417A/en
Publication of JPH0143723B2 publication Critical patent/JPH0143723B2/ja
Granted legal-status Critical Current

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NEW MATERIAL:A compound expressed by formulaI(R is straight chain or branched alkyl; R2 is H, halogen, carbamoyl, etc.; Q is direct bond or -O-; A is 1W6C alkylene; m and n are 1 or 2) and a salt thereof.
EXAMPLE: 1-Isopropylamino-3-[3-( 2-nitratoethoxy )phenoxy]-2-propanol expressed by formula II.
USE: A remedy for circulatory diseases having vascular smooth muscle relaxing, heart rate reducing action due to adrenergic β- and α-blocking actions, reducing action on myocardial oxygen consumption, blood flow increasing, hypotensive actions, etc.
PROCESS: 2-[(3-Ethoxycarbonyloxy)phenoxy]ethanol is converted into 2-[(3- ethoxycarbonyloxy)phenoxy]-ethyl nitrate. The 3-ethoxycarbonyloxy group is then converted into an OH group, and the resultant compound is then converted into 1,2-epoxy-3-[3-(2-nitratoethoxy)phenoxy]propane to give the exemplified compound expressed by formula II.
COPYRIGHT: (C)1982,JPO&Japio
JP1020781A 1981-01-28 1981-01-28 Remedy for circulatory disease Granted JPS57126417A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1020781A JPS57126417A (en) 1981-01-28 1981-01-28 Remedy for circulatory disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1020781A JPS57126417A (en) 1981-01-28 1981-01-28 Remedy for circulatory disease

Publications (2)

Publication Number Publication Date
JPS57126417A true JPS57126417A (en) 1982-08-06
JPH0143723B2 JPH0143723B2 (en) 1989-09-22

Family

ID=11743818

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1020781A Granted JPS57126417A (en) 1981-01-28 1981-01-28 Remedy for circulatory disease

Country Status (1)

Country Link
JP (1) JPS57126417A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328903A (en) * 1990-04-28 1994-07-12 Taisho Pharmaceutical Co. Ltd. Composition for solid pharmaceutical preparations containing vitamin D3 derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328903A (en) * 1990-04-28 1994-07-12 Taisho Pharmaceutical Co. Ltd. Composition for solid pharmaceutical preparations containing vitamin D3 derivative

Also Published As

Publication number Publication date
JPH0143723B2 (en) 1989-09-22

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