JPS57106614A - Preparation of prolonged release type composite - Google Patents
Preparation of prolonged release type compositeInfo
- Publication number
- JPS57106614A JPS57106614A JP18153080A JP18153080A JPS57106614A JP S57106614 A JPS57106614 A JP S57106614A JP 18153080 A JP18153080 A JP 18153080A JP 18153080 A JP18153080 A JP 18153080A JP S57106614 A JPS57106614 A JP S57106614A
- Authority
- JP
- Japan
- Prior art keywords
- prolonged release
- type composite
- release type
- powdery
- active substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002035 prolonged effect Effects 0.000 title abstract 5
- 239000002131 composite material Substances 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 239000013543 active substance Substances 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000011369 resultant mixture Substances 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- -1 beomycin drochloride Substances 0.000 abstract 1
- 230000000857 drug effect Effects 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 108010054442 polyalanine Proteins 0.000 abstract 1
- 108010094020 polyglycine Proteins 0.000 abstract 1
- 229920000232 polyglycine polymer Polymers 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To obtain a prolonged release type composite having improved prolonged release properties and the desired shape, by mixing a powdery polypeptid with a powdery physiologically active substance, and treating the resultant mixture under pressure.
CONSTITUTION: A powdery polypeptide, e.g. poly-alanine or polyglycine, is mixed with a physiologically active substance, e.g. beomycin drochloride, growth hormone, or antihistaminic agent, and the resultant mixture is then treated under a pressure of 50W20,000kg/cm2 to give the aimed prolonged release type composite of desired shape. According to the method, the polypeptide becomes a film in appearance, and the physiologically active substance is uniformly dispersed and covered with the film-like polypeptide to give the prolonged release type composite having a long duration of drug effects. The two components must be finely pulverized prior to the mixing thereof, e.g. by a method of pulverizing the components in a forzen state at -190°C (liquid nitrogen temperature).
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18153080A JPS57106614A (en) | 1980-12-22 | 1980-12-22 | Preparation of prolonged release type composite |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18153080A JPS57106614A (en) | 1980-12-22 | 1980-12-22 | Preparation of prolonged release type composite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57106614A true JPS57106614A (en) | 1982-07-02 |
Family
ID=16102372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18153080A Pending JPS57106614A (en) | 1980-12-22 | 1980-12-22 | Preparation of prolonged release type composite |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57106614A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4842604A (en) * | 1985-02-19 | 1989-06-27 | The Dow Chemical Company | Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics |
-
1980
- 1980-12-22 JP JP18153080A patent/JPS57106614A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4842604A (en) * | 1985-02-19 | 1989-06-27 | The Dow Chemical Company | Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2075403T3 (en) | PROCEDURE FOR THE MANUFACTURE OF PELLETS. | |
| DE3369070D1 (en) | Lyophilized compositions, preparation and use thereof | |
| JPS5213599A (en) | Preparation of aqueous polyurethane emulsion | |
| JPS5658469A (en) | Molding method of glucomannan flour | |
| JPS57106614A (en) | Preparation of prolonged release type composite | |
| JPS553424A (en) | Water swelling resin composition | |
| JPS5380426A (en) | Dye composition | |
| JPS5747339A (en) | Water-containing composite and its production | |
| JPS55141181A (en) | Production of germ-free potage soup | |
| JPS5537119A (en) | Preparation of instant creaming powder | |
| JPS5585385A (en) | Powdered food and drink | |
| JPS5365875A (en) | Preparation of benzenesulfone amide derivs. | |
| JPS5758873A (en) | Preparation of fish-paste product | |
| JPS57179122A (en) | Blood coagulation factor ix preparation for oral administration | |
| JPS57197210A (en) | Method for preparation of slow-releasing composite | |
| JPS5721315A (en) | Stable solid preparation of cytochrome c and its preparation | |
| JPS57203001A (en) | Cockroach out | |
| JPS54139613A (en) | Solid fat product and its production | |
| JPS57116016A (en) | Bile crystal and its preparation | |
| KR870000016A (en) | Method for preparing cold water soluble coffee mixture | |
| JPS5630915A (en) | Soft gelatin capsule | |
| JPS5693787A (en) | Liquid agent injection method | |
| JPS57130904A (en) | Formed preparation with good permanence | |
| JPS57147532A (en) | Modifying method of molded polyethylene and polypropylene | |
| JPS5648858A (en) | Preparation of toy feed for keep dog |