JPS5648888A - Preparation of optical active compound - Google Patents
Preparation of optical active compoundInfo
- Publication number
- JPS5648888A JPS5648888A JP12415479A JP12415479A JPS5648888A JP S5648888 A JPS5648888 A JP S5648888A JP 12415479 A JP12415479 A JP 12415479A JP 12415479 A JP12415479 A JP 12415479A JP S5648888 A JPS5648888 A JP S5648888A
- Authority
- JP
- Japan
- Prior art keywords
- ester
- active compound
- acyloxy
- optical active
- asymmetric hydrolysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000003287 optical effect Effects 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 abstract 7
- 125000004423 acyloxy group Chemical group 0.000 abstract 3
- 230000007062 hydrolysis Effects 0.000 abstract 3
- 238000006460 hydrolysis reaction Methods 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 108090001060 Lipase Proteins 0.000 abstract 2
- 102000004882 Lipase Human genes 0.000 abstract 2
- 239000004367 Lipase Substances 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- 235000019421 lipase Nutrition 0.000 abstract 2
- 125000000466 oxiranyl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000159512 Geotrichum Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005042 acyloxymethyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- -1 e.g. Proteins 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004970 halomethyl group Chemical group 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 108091016642 steapsin Proteins 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare an optical active compound industrially advantageously, by subjecting a specific ester to asymmetric hydrolysis with a lipase capable of hydrolyzing the ester asymmetrically.
CONSTITUTION: A lipase, e.g., steapsin, or a bacterium, e.g., one belonging to the genus Geotrichum, capable of hydrolyzing an ester asymmetrically, and the ester shown by the formula (X is acyloxy; Y is hologen, acyloxy, or oxygen which forms oxirane ring in combination with Z; Z is holomethyl or acyloxymethyl when Y is halogen, Z is halomethyl or aryl when Y is acyloxy, and Z is methylene which forms oxirane ring in combination with Y when Y is oxygen) are added to a buffer solution sufficiently enough to neutralize an acid to be formed in asymmetric hydrolysis, and the ester is subjected to asymmetric hydrolysis. The ester and alcohol are extracted with an organic solvent, and the ester is separated from alcohol by washing with water, chromatography, etc. to give an optical active compound.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12415479A JPS5648888A (en) | 1979-09-28 | 1979-09-28 | Preparation of optical active compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12415479A JPS5648888A (en) | 1979-09-28 | 1979-09-28 | Preparation of optical active compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5648888A true JPS5648888A (en) | 1981-05-02 |
| JPS6155954B2 JPS6155954B2 (en) | 1986-11-29 |
Family
ID=14878270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12415479A Granted JPS5648888A (en) | 1979-09-28 | 1979-09-28 | Preparation of optical active compound |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5648888A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58169337A (en) * | 1982-03-31 | 1983-10-05 | Hitachi Ltd | Device for recording and detecting mark in optical disc |
| JPS61192074A (en) * | 1985-02-20 | 1986-08-26 | Canon Inc | Information record carrier |
| JPH01257484A (en) * | 1987-12-14 | 1989-10-13 | Idemitsu Kosan Co Ltd | Method for producing optically active secondary alcohol |
| US4985365A (en) * | 1981-11-28 | 1991-01-15 | Sumitomo Chemical Company, Ltd. | Process for producing optically active benzyl alcohol compound |
| JPH05189882A (en) * | 1992-06-29 | 1993-07-30 | Hitachi Ltd | Recorder/reproducer |
| JPH06295472A (en) * | 1993-12-15 | 1994-10-21 | Hitachi Ltd | Optical disc media |
| JPH0855430A (en) * | 1995-08-09 | 1996-02-27 | Hitachi Ltd | Information recording device and optical information recording medium |
-
1979
- 1979-09-28 JP JP12415479A patent/JPS5648888A/en active Granted
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4985365A (en) * | 1981-11-28 | 1991-01-15 | Sumitomo Chemical Company, Ltd. | Process for producing optically active benzyl alcohol compound |
| JPS58169337A (en) * | 1982-03-31 | 1983-10-05 | Hitachi Ltd | Device for recording and detecting mark in optical disc |
| JPS61192074A (en) * | 1985-02-20 | 1986-08-26 | Canon Inc | Information record carrier |
| JPH01257484A (en) * | 1987-12-14 | 1989-10-13 | Idemitsu Kosan Co Ltd | Method for producing optically active secondary alcohol |
| JPH05189882A (en) * | 1992-06-29 | 1993-07-30 | Hitachi Ltd | Recorder/reproducer |
| JPH06295472A (en) * | 1993-12-15 | 1994-10-21 | Hitachi Ltd | Optical disc media |
| JPH0855430A (en) * | 1995-08-09 | 1996-02-27 | Hitachi Ltd | Information recording device and optical information recording medium |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6155954B2 (en) | 1986-11-29 |
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