JPS5620587A - Beta-lactam antibiotic - Google Patents
Beta-lactam antibioticInfo
- Publication number
- JPS5620587A JPS5620587A JP9582379A JP9582379A JPS5620587A JP S5620587 A JPS5620587 A JP S5620587A JP 9582379 A JP9582379 A JP 9582379A JP 9582379 A JP9582379 A JP 9582379A JP S5620587 A JPS5620587 A JP S5620587A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reacted
- give
- lactam antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I [R1 is H, halogen, amino, phenylglycylamido, R3CONH, etc. (R3 is phenylmethyl, etc.); R2 is benzothiazolyl], and its salt.
EXAMPLE: 3-Phenylacetamido-4-(benzothiazol-2-yl)-dithioazetidin-2-one.
USE: A β-lactam antibiotic, an intermediate thereof, an antimicrobial agent, a β- lactamase inhibitor and an antifungal agent.
PROCESS: A compound of formula II (M is H, K+, etc.) is oxidized to give a compound of formula III, which is reacted with a chloroformate in the presence of a base to form a mixed acid anhydride. The anhydride is then reacted with an aqueous sodium azide to give a compound of formula IV, which is heated in a mixed solution of sulfuric acid, dioxane and water under refluxing to afford a compound of formula V. The resulting compound is then reacted with a 2-mercaptobenzothiazole in a high-boiling solvent to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9582379A JPS5620587A (en) | 1979-07-26 | 1979-07-26 | Beta-lactam antibiotic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9582379A JPS5620587A (en) | 1979-07-26 | 1979-07-26 | Beta-lactam antibiotic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5620587A true JPS5620587A (en) | 1981-02-26 |
Family
ID=14148121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9582379A Pending JPS5620587A (en) | 1979-07-26 | 1979-07-26 | Beta-lactam antibiotic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5620587A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2541277A1 (en) * | 1982-11-29 | 1984-08-24 | Otsuka Kagaku Yakuhin | AZETIDINONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION |
| US5201591A (en) * | 1991-01-08 | 1993-04-13 | Canon Business Machines, Inc. | Character printing device with pressure impact control |
-
1979
- 1979-07-26 JP JP9582379A patent/JPS5620587A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2541277A1 (en) * | 1982-11-29 | 1984-08-24 | Otsuka Kagaku Yakuhin | AZETIDINONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION |
| US5201591A (en) * | 1991-01-08 | 1993-04-13 | Canon Business Machines, Inc. | Character printing device with pressure impact control |
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