JPS56138168A - Movel active vitamin d3 derivative composition - Google Patents
Movel active vitamin d3 derivative compositionInfo
- Publication number
- JPS56138168A JPS56138168A JP4037080A JP4037080A JPS56138168A JP S56138168 A JPS56138168 A JP S56138168A JP 4037080 A JP4037080 A JP 4037080A JP 4037080 A JP4037080 A JP 4037080A JP S56138168 A JPS56138168 A JP S56138168A
- Authority
- JP
- Japan
- Prior art keywords
- active vitamin
- antioxidant
- formula
- acid
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003704 vitamin D3 derivatives Chemical class 0.000 title abstract 4
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 4
- 239000003963 antioxidant agent Substances 0.000 abstract 4
- 230000003078 antioxidant effect Effects 0.000 abstract 4
- 239000003613 bile acid Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 abstract 2
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 abstract 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 abstract 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- XWJTYEGVQBFZHI-IMPNNSMHSA-N Apocholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1C2=C2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 XWJTYEGVQBFZHI-IMPNNSMHSA-N 0.000 abstract 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004380 Cholic acid Substances 0.000 abstract 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 abstract 1
- 235000019416 cholic acid Nutrition 0.000 abstract 1
- 229960002471 cholic acid Drugs 0.000 abstract 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 abstract 1
- 229960003964 deoxycholic acid Drugs 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 208000005368 osteomalacia Diseases 0.000 abstract 1
- 239000000473 propyl gallate Substances 0.000 abstract 1
- 229940075579 propyl gallate Drugs 0.000 abstract 1
- 235000010388 propyl gallate Nutrition 0.000 abstract 1
- 208000007442 rickets Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
- 239000011647 vitamin D3 Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: The titled composition, containing an active vitamin D3 derivative, a bile acid and an antioxidant, and having improved chemical stability of the active vitamin D3 derivative.
CONSTITUTION: A composition containing at least one of active vitamin D3 derivative of hydroxycholecalciferol expressed by the formula (R1, R2 and R3 are H or OH; however, at least one of R1, R2 and R3 is OH), a bile acid, e.g. deoxycholic acid, cholic acid or apocholic acid, and an antioxidant, e.g. butylhydroxytoluene, propyl gallate or lecithin. The amount of the bile acid is in the range of 10W100,000 times that of the compound of the formula, and that of the antioxidant is in the range of 10W10,000 times that of the compound of the formula. The compound of the formula is useful for rachitis and osteomalacia caused by the vitamin D3 metabolism. The addition of the bile acid and the antioxidant renders the pharmaceutical stable to light and heat and storable for a long time.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4037080A JPS56138168A (en) | 1980-03-31 | 1980-03-31 | Movel active vitamin d3 derivative composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4037080A JPS56138168A (en) | 1980-03-31 | 1980-03-31 | Movel active vitamin d3 derivative composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56138168A true JPS56138168A (en) | 1981-10-28 |
| JPS6248667B2 JPS6248667B2 (en) | 1987-10-15 |
Family
ID=12578749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4037080A Granted JPS56138168A (en) | 1980-03-31 | 1980-03-31 | Movel active vitamin d3 derivative composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56138168A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6431722A (en) * | 1987-07-22 | 1989-02-02 | Teva Pharma | Composition of cholecalciferol derivative for treating renal bone disease |
| WO1990003173A1 (en) * | 1988-09-26 | 1990-04-05 | Teijin Limited | Stable aqueous preparation of active vitamin d¿3? |
| WO2004091667A1 (en) * | 2003-04-15 | 2004-10-28 | Axcess Limited | Uptake of macromolecules |
| JP2006523662A (en) * | 2003-04-15 | 2006-10-19 | アクセス リミテッド | Absorption enhancers such as BHT, BHA or propyl gallate |
-
1980
- 1980-03-31 JP JP4037080A patent/JPS56138168A/en active Granted
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6431722A (en) * | 1987-07-22 | 1989-02-02 | Teva Pharma | Composition of cholecalciferol derivative for treating renal bone disease |
| WO1990003173A1 (en) * | 1988-09-26 | 1990-04-05 | Teijin Limited | Stable aqueous preparation of active vitamin d¿3? |
| WO2004091667A1 (en) * | 2003-04-15 | 2004-10-28 | Axcess Limited | Uptake of macromolecules |
| JP2006523662A (en) * | 2003-04-15 | 2006-10-19 | アクセス リミテッド | Absorption enhancers such as BHT, BHA or propyl gallate |
| JP2006523663A (en) * | 2003-04-15 | 2006-10-19 | アクセス リミテッド | Polymer uptake |
| US7651995B2 (en) | 2003-04-15 | 2010-01-26 | Axcess Limited | Absorption enhancers such as e.g. BHT, BHA or propyl gallate |
| US8314058B2 (en) | 2003-04-15 | 2012-11-20 | Axcess Limited | Uptake of macromolecules |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6248667B2 (en) | 1987-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS57150616A (en) | Carbonic acid ester solution of pge type compound | |
| NO157802C (en) | PROCEDURE FOR REDUCING SWEETNESS IN A EDIBLE PRODUCT. | |
| IE792135L (en) | 1-hydroxylated vitamin d compounds | |
| JPS5432460A (en) | Cycloalkylidenemethylphenylacetic acid derivative and their preparation | |
| JPS56138168A (en) | Movel active vitamin d3 derivative composition | |
| EP0112451A3 (en) | Prostaglandin and hydroxylated fatty acid ester formulations | |
| JPS5569562A (en) | Stabilization of active vitamin d3 derivative | |
| JPS5740461A (en) | Novel activated vitamin d3 derivative composition | |
| JPS5740414A (en) | Novel active type vitamin d3 derivative composition | |
| JPS5683465A (en) | Method for preventing deterioration in quality of amine oxide | |
| JPS5764660A (en) | N-hydroxysulfoalkylaminine derivative and its application | |
| JPS57181012A (en) | Drug composed of polyprenyl compound | |
| JPS5740415A (en) | Novel active type vitamin d3 derivative composition | |
| JPS5758890A (en) | Preparation of glucosylmoranoline derivative | |
| JPS5274583A (en) | Anti-degrading agent | |
| JPS5746915A (en) | Antiallergic agent | |
| JPS5646808A (en) | Carcinostatic agent | |
| JPS5334762A (en) | Preparation of diterpene derivatives | |
| JPS532559A (en) | Polyester compositions | |
| JPS53145917A (en) | Insecticidal, miticidal composition | |
| JPS5221056A (en) | Light stable polyurethane compositions | |
| EP0131927A3 (en) | Pharmaceutical preparation containing isosorbide dinitrate | |
| JPS5785343A (en) | Trans-4-alkylcyclohexanecarboxylic 3'-fluoro-4'- alkoxyphenyl ester | |
| JPS5223156A (en) | Photo-stable polyurethane composition | |
| JPS53148536A (en) | Carcinostatic agent containing trans-4-aminomethylcyclohexane-1-carboxylic acid derivative |