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JPS56133236A - Sodium valproate clathrate - Google Patents

Sodium valproate clathrate

Info

Publication number
JPS56133236A
JPS56133236A JP3578780A JP3578780A JPS56133236A JP S56133236 A JPS56133236 A JP S56133236A JP 3578780 A JP3578780 A JP 3578780A JP 3578780 A JP3578780 A JP 3578780A JP S56133236 A JPS56133236 A JP S56133236A
Authority
JP
Japan
Prior art keywords
clathrate
cyclodextrin
sodium valproate
sodium
clathrating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3578780A
Other languages
Japanese (ja)
Inventor
Toshikazu Abe
Naotake Shimaguchi
Tadashi Nakatani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP3578780A priority Critical patent/JPS56133236A/en
Publication of JPS56133236A publication Critical patent/JPS56133236A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To provide the titled clathrate by clathrating sodium valporate useful as an antiepileptic using cyclodextrin, thereby suppressing the deliquescence of the compound while keeping the high rate of elution thereof from the clathrate.
CONSTITUTION: A sodium valproate clathrate is prepared by clathrating sodium valproate (2-n-propylvaleric acid sodium salt) with cyclodextrin. The amount of sodium valproate is usually 0.5W10mol per 1mol of cyclodextrin. The clathrating procedure is, e.g. as follows. Cyclodextrin and sodium valproate are mixed with water, and if necessary heated to obtain a suspension or solution. When the cyclodextrin is present in the form of dispersion, the composition is mixed thoroughly with a mixer, etc., optionally filtered, and dried to obtain the objective sodium valproate clathrate.
COPYRIGHT: (C)1981,JPO&Japio
JP3578780A 1980-03-22 1980-03-22 Sodium valproate clathrate Pending JPS56133236A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3578780A JPS56133236A (en) 1980-03-22 1980-03-22 Sodium valproate clathrate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3578780A JPS56133236A (en) 1980-03-22 1980-03-22 Sodium valproate clathrate

Publications (1)

Publication Number Publication Date
JPS56133236A true JPS56133236A (en) 1981-10-19

Family

ID=12451615

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3578780A Pending JPS56133236A (en) 1980-03-22 1980-03-22 Sodium valproate clathrate

Country Status (1)

Country Link
JP (1) JPS56133236A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040060A1 (en) * 1997-03-11 1998-09-17 Hexal Ag Solid, non-deliquescent formulations of sodium valproate
WO2008090585A3 (en) * 2007-01-26 2009-02-26 Univ Roma Soluble forms of inclusion complexes of histone deacetylase inhibitors and cyclodextrins, their preparation processes and uses in the pharmaceutical field

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040060A1 (en) * 1997-03-11 1998-09-17 Hexal Ag Solid, non-deliquescent formulations of sodium valproate
WO2008090585A3 (en) * 2007-01-26 2009-02-26 Univ Roma Soluble forms of inclusion complexes of histone deacetylase inhibitors and cyclodextrins, their preparation processes and uses in the pharmaceutical field

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