JPS56127098A - Preparation of saponin by enzymatic hydrolysis - Google Patents
Preparation of saponin by enzymatic hydrolysisInfo
- Publication number
- JPS56127098A JPS56127098A JP6150780A JP6150780A JPS56127098A JP S56127098 A JPS56127098 A JP S56127098A JP 6150780 A JP6150780 A JP 6150780A JP 6150780 A JP6150780 A JP 6150780A JP S56127098 A JPS56127098 A JP S56127098A
- Authority
- JP
- Japan
- Prior art keywords
- saponin
- glucopyranosyl
- group
- enzymatic hydrolysis
- saccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000001397 quillaja saponaria molina bark Substances 0.000 title abstract 4
- 229930182490 saponin Natural products 0.000 title abstract 4
- 150000007949 saponins Chemical class 0.000 title abstract 3
- 230000007071 enzymatic hydrolysis Effects 0.000 title abstract 2
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 title abstract 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010059892 Cellulase Proteins 0.000 abstract 1
- 108090000604 Hydrolases Proteins 0.000 abstract 1
- 102000004157 Hydrolases Human genes 0.000 abstract 1
- 229930182473 O-glycoside Natural products 0.000 abstract 1
- FHICGHSMIPIAPL-HDYAAECPSA-N [2-[3-[6-[3-[(5R,6aS,6bR,12aR)-10-[6-[2-[2-[4,5-dihydroxy-3-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]ethoxy]ethyl]-3,4,5-trihydroxyoxan-2-yl]oxy-5-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carbonyl]peroxypropyl]-5-[[5-[8-[3,5-dihydroxy-4-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]octoxy]-3,4-dihydroxy-6-methyloxan-2-yl]methoxy]-3,4-dihydroxyoxan-2-yl]propoxymethyl]-5-hydroxy-3-[(6S)-6-hydroxy-2,6-dimethylocta-2,7-dienoyl]oxy-6-methyloxan-4-yl] (2E,6S)-6-hydroxy-2-(hydroxymethyl)-6-methylocta-2,7-dienoate Chemical compound C=C[C@@](C)(O)CCC=C(C)C(=O)OC1C(OC(=O)C(\CO)=C\CC[C@](C)(O)C=C)C(O)C(C)OC1COCCCC1C(O)C(O)C(OCC2C(C(O)C(OCCCCCCCCC3C(C(OC4C(C(O)C(O)CO4)O)C(O)CO3)O)C(C)O2)O)C(CCCOOC(=O)C23C(CC(C)(C)CC2)C=2[C@@]([C@]4(C)CCC5C(C)(C)C(OC6C(C(O)C(O)C(CCOCCC7C(C(O)C(O)CO7)OC7C(C(O)C(O)CO7)O)O6)O)CC[C@]5(C)C4CC=2)(C)C[C@H]3O)O1 FHICGHSMIPIAPL-HDYAAECPSA-N 0.000 abstract 1
- 102000016679 alpha-Glucosidases Human genes 0.000 abstract 1
- 108010028144 alpha-Glucosidases Proteins 0.000 abstract 1
- 229940106157 cellulase Drugs 0.000 abstract 1
- 108010030923 hesperidinase Proteins 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- -1 saponin compounds Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
PURPOSE: To prepare a saponin derivative useful as a raw material of other compounds and known saponin compounds, by eliminting at least one saccharide from the substutuent at a specific position by the enzymatic hydrolysis of saponin, and purifying and separating the products.
CONSTITUTION: A novel saponin of formula (when R1 is [β-D-glucopyranosyl(1- →2)-α-L-rhamno-pyranosyl(1→6)]-β-D-glucopyranosyl group, then R2 is H, β-D- glucopyranosyl(1→6)-β-D-glucopyranosyl group, etc. and R3 is H, hydroxyl group, etc.) is made to contact with a hydrolase capable of braking the O-glycoside bond, e.g. hesperidinase, maltase, cellulase, etc. By this treatment, at least one saccharide is removed from the substituent group at the 3- and/or 20-position of the compound of formula. If necessary, the product is separated and purified.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6150780A JPS56127098A (en) | 1980-05-08 | 1980-05-08 | Preparation of saponin by enzymatic hydrolysis |
| DE19803042117 DE3042117A1 (en) | 1980-03-11 | 1980-11-07 | GYNOSAPONINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAL PREPARATIONS CONTAINING THESE COMPOUNDS |
| US06/205,377 US4339442A (en) | 1980-03-11 | 1980-11-07 | Gynosaponins, their use and a process for preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6150780A JPS56127098A (en) | 1980-05-08 | 1980-05-08 | Preparation of saponin by enzymatic hydrolysis |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55030636A Division JPS6043359B2 (en) | 1980-03-11 | 1980-03-11 | Gynosaponins and their production method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56127098A true JPS56127098A (en) | 1981-10-05 |
Family
ID=13173068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6150780A Pending JPS56127098A (en) | 1980-03-11 | 1980-05-08 | Preparation of saponin by enzymatic hydrolysis |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56127098A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100420451B1 (en) * | 2001-11-27 | 2004-03-02 | 주식회사 케이티앤지 | The manufacturing method for ginsenoside compound k with cellulase or lactase composition y-ao |
| KR100424438B1 (en) * | 1998-05-07 | 2004-05-20 | 주식회사 케이티앤지 | Enzymatic producing method of ginsenoside rd |
-
1980
- 1980-05-08 JP JP6150780A patent/JPS56127098A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100424438B1 (en) * | 1998-05-07 | 2004-05-20 | 주식회사 케이티앤지 | Enzymatic producing method of ginsenoside rd |
| KR100420451B1 (en) * | 2001-11-27 | 2004-03-02 | 주식회사 케이티앤지 | The manufacturing method for ginsenoside compound k with cellulase or lactase composition y-ao |
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