JPS56122328A - Crystalline amine salt of methanoplastocyclin, its preparation and purifying method - Google Patents
Crystalline amine salt of methanoplastocyclin, its preparation and purifying methodInfo
- Publication number
- JPS56122328A JPS56122328A JP2572680A JP2572680A JPS56122328A JP S56122328 A JPS56122328 A JP S56122328A JP 2572680 A JP2572680 A JP 2572680A JP 2572680 A JP2572680 A JP 2572680A JP S56122328 A JPS56122328 A JP S56122328A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- methanoplastocyclin
- preparation
- amine salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A dicyclohexylamine salt of a compound expressed by formula I [R1 is trityloxymethyl, 3-trityloxy-trans-1-propenyl or group of formula II (R2, R3 and R4 are H or methyl)].
EXAMPLE: Dicyclohexylamine salt of 2-β-trityloxymethyl-3α-hydroxy-7E-(4'-carboxybutylidene)-bicyclo[3.3.0]octane.
USE: An intermediate for obtaining the compound of formula I exhibiting improved crystallinity.
PROCESS: A compound of formula I alone or further containing the corresponding 7Z-isomer is mixed with dicyclohexylamine in a molar amount of 0.7W1.2 times that of the compound of formula I in a solvent, e.g. acetone or methyl ethyl ketone, and if necessary cooled to filter off the deposited crystals of the aimed compound. The recrystallization further improves the purity of the compound.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2572680A JPS56122328A (en) | 1980-02-29 | 1980-02-29 | Crystalline amine salt of methanoplastocyclin, its preparation and purifying method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2572680A JPS56122328A (en) | 1980-02-29 | 1980-02-29 | Crystalline amine salt of methanoplastocyclin, its preparation and purifying method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56122328A true JPS56122328A (en) | 1981-09-25 |
Family
ID=12173796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2572680A Pending JPS56122328A (en) | 1980-02-29 | 1980-02-29 | Crystalline amine salt of methanoplastocyclin, its preparation and purifying method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56122328A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011506599A (en) * | 2007-12-17 | 2011-03-03 | ユナイテッド セラピューティクス コーポレーション | Improved process for producing treprostinil, an active ingredient of remodulin |
| US9593061B2 (en) | 2014-10-20 | 2017-03-14 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
-
1980
- 1980-02-29 JP JP2572680A patent/JPS56122328A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10548863B2 (en) | 2007-12-17 | 2020-02-04 | United Therapeutics Corporation | Process to prepare treprostinil, the active ingredient in Remodulin® |
| US8748657B2 (en) | 2007-12-17 | 2014-06-10 | United Therapeutics Corporation | Process to prepare treprostinil |
| US9156786B2 (en) | 2007-12-17 | 2015-10-13 | United Therapeutics Corporation | Process to prepare treprostinil, the active ingredient in remodulin® |
| US9593066B2 (en) | 2007-12-17 | 2017-03-14 | United Therapeutics Corporation | Process to prepare treprostinil, the active ingredient in remodulin® |
| US9604901B2 (en) | 2007-12-17 | 2017-03-28 | United Therapeutics Corporation | Process to prepare treprostinil, the active ingredient in Remodulin® |
| US10322099B2 (en) | 2007-12-17 | 2019-06-18 | United Therapeutics Corporation | Process to prepare treprostinil, the active ingredient in remodulin® |
| US10478410B2 (en) | 2007-12-17 | 2019-11-19 | United Therapeutics Corporation | Process to prepare treprostinil, the active ingredient in Remodulin® |
| JP2011506599A (en) * | 2007-12-17 | 2011-03-03 | ユナイテッド セラピューティクス コーポレーション | Improved process for producing treprostinil, an active ingredient of remodulin |
| US11723887B2 (en) | 2007-12-17 | 2023-08-15 | United Therapeutics Corporation | Process to prepare treprostinil, the active ingredient in Remodulin® |
| US9593061B2 (en) | 2014-10-20 | 2017-03-14 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
| US10196342B2 (en) | 2014-10-20 | 2019-02-05 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
| US10774027B2 (en) | 2014-10-20 | 2020-09-15 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
| US11225452B2 (en) | 2014-10-20 | 2022-01-18 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
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