JPS56108758A - Sulfonate derivative and its preparation - Google Patents
Sulfonate derivative and its preparationInfo
- Publication number
- JPS56108758A JPS56108758A JP1121480A JP1121480A JPS56108758A JP S56108758 A JPS56108758 A JP S56108758A JP 1121480 A JP1121480 A JP 1121480A JP 1121480 A JP1121480 A JP 1121480A JP S56108758 A JPS56108758 A JP S56108758A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- solvent
- sulfonate derivative
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- -1 sulfonic acid compound Chemical class 0.000 abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- MCUZAJNWJMVUQJ-UHFFFAOYSA-N 2-oxopentyl ethanesulfonate Chemical compound CCCC(=O)COS(=O)(=O)CC MCUZAJNWJMVUQJ-UHFFFAOYSA-N 0.000 abstract 1
- 108090000317 Chymotrypsin Proteins 0.000 abstract 1
- 108090000371 Esterases Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 239000003524 antilipemic agent Substances 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 229960002376 chymotrypsin Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A sulfonate derivative of formula I (R1 is 1W4C alkyl, 2W6C alkoxyalkyl, aralkyl, etc.; R2 is 1W15C alkyl or 2W15C alkenyl).
EXAMPLE: 2-Oxopentylethanesulfonate.
USE: An antilipemic agent, an anti-inflammatory agent and an immunosuppressive agent having an inhibitory action on esterase and chymotrypsin.
PROCESS: A compound of formula II is reacted with a sulfonic acid compound of formula III (m is 0 or an integer 1 or 2) usually in a solvent at a temperature of about -10W60°C to give the compound of formula I. The amount of the sulfonic acid compound expressed by formula III used is preferably equimolar or more with the compound of formula II. An aprotic solvent, e.g. ether, is preferred as the solvent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1121480A JPS6059904B2 (en) | 1980-01-31 | 1980-01-31 | Sulfonate derivative and method for producing the same |
| US06/225,979 US4411911A (en) | 1980-01-31 | 1981-01-19 | Method of treating hyperlipidemia and inflammation with sulfonate derivatives |
| GB8101888A GB2068371B (en) | 1980-01-31 | 1981-01-22 | Sulphonate derivatives |
| AU66677/81A AU527933B2 (en) | 1980-01-31 | 1981-01-28 | Sulphonate derivatives |
| CA000369549A CA1167046A (en) | 1980-01-31 | 1981-01-28 | Sulfonate derivatives |
| IT8167106A IT1210604B (en) | 1980-01-31 | 1981-01-28 | 2-Oxo-alkyl sulphonate ester(s) |
| CH599/81A CH655098A5 (en) | 1980-01-31 | 1981-01-29 | SULPHONATE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THE SAME. |
| FR8101712A FR2475041A1 (en) | 1980-01-31 | 1981-01-29 | SULFONIC ESTERS OF KETO-ALCOHOLS, THEIR PREPARATION AND DRUG CONTAINING THESE SUBSTANCES |
| DE19813103144 DE3103144A1 (en) | 1980-01-31 | 1981-01-30 | NEW SULPHONATES, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THEM |
| ES499527A ES8201964A1 (en) | 1980-01-31 | 1981-01-30 | Method of treating hyperlipidemia and inflammation with sulfonate derivatives |
| NLAANVRAGE8100494,A NL185343C (en) | 1980-01-31 | 1981-02-02 | FORMED PHARMACEUTICAL PREPARATIONS WITH ANTILIPEMIC ANTI-INFLAMMATORY AND IMMUNITY-CONTROLLING EFFECTS AND SUITABLE SULFONATE COMPOUNDS AND A METHOD OF PREPARATION. |
| US06/492,873 US4489091A (en) | 1980-01-31 | 1983-05-09 | Antilipemic and anti-inflammatory compositions containing sulfonate derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1121480A JPS6059904B2 (en) | 1980-01-31 | 1980-01-31 | Sulfonate derivative and method for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56108758A true JPS56108758A (en) | 1981-08-28 |
| JPS6059904B2 JPS6059904B2 (en) | 1985-12-27 |
Family
ID=11771725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1121480A Expired JPS6059904B2 (en) | 1980-01-31 | 1980-01-31 | Sulfonate derivative and method for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6059904B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0542328Y2 (en) * | 1987-12-01 | 1993-10-26 |
-
1980
- 1980-01-31 JP JP1121480A patent/JPS6059904B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6059904B2 (en) | 1985-12-27 |
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