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JPS56103198A - 3',4',6''-trideoxyamikacin and its preparation - Google Patents

3',4',6''-trideoxyamikacin and its preparation

Info

Publication number
JPS56103198A
JPS56103198A JP565780A JP565780A JPS56103198A JP S56103198 A JPS56103198 A JP S56103198A JP 565780 A JP565780 A JP 565780A JP 565780 A JP565780 A JP 565780A JP S56103198 A JPS56103198 A JP S56103198A
Authority
JP
Japan
Prior art keywords
groups
hydroxyl
positions
protecting groups
protecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP565780A
Other languages
Japanese (ja)
Other versions
JPS631954B2 (en
Inventor
Hamao Umezawa
Shinichi Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP565780A priority Critical patent/JPS56103198A/en
Publication of JPS56103198A publication Critical patent/JPS56103198A/en
Publication of JPS631954B2 publication Critical patent/JPS631954B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I and an acid addition salt thereof.
EXAMPLE: 3',4',6''-Trideoxyamikacin carbonate.
USE: An antimicrobial agent having low toxicity to an organ of hearing.
PROCESS: Four amino groups of 3',4'-dideoxyamikacin expressed by formula II are protected by protecting groups thereof, and three hydroxyl groups at the 2',2'' and 2'''-positions or four hydroxyl groups at the 5, 2',2'''-positions are protected by monovalent protecting groups to give compound of formula III (A is H; B is monovalent protecting group of the amino groups; A and B together form bivalent protecting groups of the amino groups; X and Y are H, alkyl, aryl, etc.; D is acyl group; E is H or acyl groups). The protecting groups at the 4'' and 6''-positions are then removed, and the hydroxyl group at the 6''-position is selectively sulfonated, iodinated and dehalogenated by the catalytic reduction. The remaining protecting groups of the hydroxyl and amino groups are then removed.
COPYRIGHT: (C)1981,JPO&Japio
JP565780A 1980-01-23 1980-01-23 3',4',6''-trideoxyamikacin and its preparation Granted JPS56103198A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP565780A JPS56103198A (en) 1980-01-23 1980-01-23 3',4',6''-trideoxyamikacin and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP565780A JPS56103198A (en) 1980-01-23 1980-01-23 3',4',6''-trideoxyamikacin and its preparation

Publications (2)

Publication Number Publication Date
JPS56103198A true JPS56103198A (en) 1981-08-18
JPS631954B2 JPS631954B2 (en) 1988-01-14

Family

ID=11617178

Family Applications (1)

Application Number Title Priority Date Filing Date
JP565780A Granted JPS56103198A (en) 1980-01-23 1980-01-23 3',4',6''-trideoxyamikacin and its preparation

Country Status (1)

Country Link
JP (1) JPS56103198A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05161527A (en) * 1991-12-11 1993-06-29 Yamashita Kogyo Kenkyusho:Kk Tool holder

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01121754U (en) * 1988-02-15 1989-08-17
JPH0262148U (en) * 1988-10-31 1990-05-09
CN110709496A (en) 2017-06-14 2020-01-17 日清药业股份有限公司 Method for producing highly unsaturated fatty acid-containing composition
JPWO2020138282A1 (en) 2018-12-26 2021-11-04 日清ファルマ株式会社 Eicosapentaenoic acid alkyl ester-containing composition and method for producing the same
CN113574154A (en) 2019-03-26 2021-10-29 日清药业股份有限公司 Method for producing a composition containing alkyl eicosapentaenoate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05161527A (en) * 1991-12-11 1993-06-29 Yamashita Kogyo Kenkyusho:Kk Tool holder

Also Published As

Publication number Publication date
JPS631954B2 (en) 1988-01-14

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