[go: up one dir, main page]

JPS5566513A - Drug for arteriosclerosis comprising high polymer compound as active constituent - Google Patents

Drug for arteriosclerosis comprising high polymer compound as active constituent

Info

Publication number
JPS5566513A
JPS5566513A JP13934678A JP13934678A JPS5566513A JP S5566513 A JPS5566513 A JP S5566513A JP 13934678 A JP13934678 A JP 13934678A JP 13934678 A JP13934678 A JP 13934678A JP S5566513 A JPS5566513 A JP S5566513A
Authority
JP
Japan
Prior art keywords
drug
compound
active constituent
high polymer
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13934678A
Other languages
Japanese (ja)
Inventor
Masatsune Kurono
Takashi Iida
Takeshi Chiba
Koji Itagaki
Takeshi Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Mitsubishi Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd, Mitsubishi Chemical Industries Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP13934678A priority Critical patent/JPS5566513A/en
Priority to IT7950802A priority patent/IT7950802A0/en
Priority to FR7927955A priority patent/FR2441639A1/en
Priority to GB7939305A priority patent/GB2036048B/en
Priority to DE19792946026 priority patent/DE2946026A1/en
Publication of JPS5566513A publication Critical patent/JPS5566513A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • C08G73/022—Preparatory process from polyamines and epihalohydrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE: The title drug capable of reducing lipids in the blood and liver remarkably without side effects, comprising a specific high polymer compound having a nitrogen-containing compound combined with a bifunetional compound as an active constituent.
CONSTITUTION: A drug comprising (A) a high polymer compound which is a crosslinked polymer of (a) a bifunctional compound of formula I: [y is -CH2X (X is Cl, I, etc.); group of formula II: M is single bond, -CH2-O-CH2-, etc.; Z is -CH(OH)-CH2X, or group of formula II], e.g. epichlorohydrin, and (b) a nitrogen- containing compound, or its nontoxic salt as an active constituent. As for (b), NH3, ethylenediamine, or polyethylene-polyamine having a repeating degree of 2W1,500 may be cited. 20% or more of nitrogen atoms in the polymer are quaternary ammonium salts linked to lower alkyl groups. The drug is useful as a cholesterol absorption inhibitor.
COPYRIGHT: (C)1980,JPO&Japio
JP13934678A 1978-11-14 1978-11-14 Drug for arteriosclerosis comprising high polymer compound as active constituent Pending JPS5566513A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP13934678A JPS5566513A (en) 1978-11-14 1978-11-14 Drug for arteriosclerosis comprising high polymer compound as active constituent
IT7950802A IT7950802A0 (en) 1978-11-14 1979-11-12 POLYMER COMPOUNDS, PROCEDURE FOR PRODUCING THEM AND ANTI-ARTERIAL SCLEROSIS AGENTS THAT CONTAIN THEM
FR7927955A FR2441639A1 (en) 1978-11-14 1979-11-13 POLYMERS, PROCESS FOR THEIR PREPARATION AND ARTERIOSCLEROSIS TREATMENT AGENTS CONTAINING SUCH POLYMERS
GB7939305A GB2036048B (en) 1978-11-14 1979-11-13 Polymer compounds process for their preparation and arterio-sclerosis treating agents containing them
DE19792946026 DE2946026A1 (en) 1978-11-14 1979-11-14 POLYMER COMPOUND, METHOD FOR THE PRODUCTION THEREOF AND CONTAINING MEANS FOR THE FIGHT AGAINST ATERIOSCLEROSIS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13934678A JPS5566513A (en) 1978-11-14 1978-11-14 Drug for arteriosclerosis comprising high polymer compound as active constituent

Publications (1)

Publication Number Publication Date
JPS5566513A true JPS5566513A (en) 1980-05-20

Family

ID=15243181

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13934678A Pending JPS5566513A (en) 1978-11-14 1978-11-14 Drug for arteriosclerosis comprising high polymer compound as active constituent

Country Status (5)

Country Link
JP (1) JPS5566513A (en)
DE (1) DE2946026A1 (en)
FR (1) FR2441639A1 (en)
GB (1) GB2036048B (en)
IT (1) IT7950802A0 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5879022A (en) * 1981-11-04 1983-05-12 Bitamin Kenkyusho:Kk Novel metal-crosslinked polymer compound containing quaternary nitrogen atom, its preparation, and remedy for hyperlipemia containing said polymer compound as active component

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3901527A1 (en) * 1989-01-20 1990-07-26 Hoechst Ag ALKYLATED POLYETHYLENE IMIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL PREPARATIONS
US5556619A (en) * 1992-08-20 1996-09-17 The Du Pont Merck Pharmaceutical Company Crosslinked polymeric ammonium salts
HUT72658A (en) * 1992-08-20 1996-05-28 Du Pont Crosslinked polymeric ammonium salts and pharmaceutical compositions containing them
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
MX9602812A (en) * 1994-01-18 1997-06-28 Du Pont Crosslinked polymeric ammonium salts.
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US6190649B1 (en) 1999-04-23 2001-02-20 Geltex Pharmaceuticals, Inc. Polyether-based bile acid sequestrants
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
AT409629B (en) * 2000-09-14 2002-09-25 Dsm Fine Chem Austria Gmbh WASHING METHOD FOR CLEANING N-BZW. POLYMERS CONTAINING AMINO OR AMMONIUM GROUPS
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
EP1951266A2 (en) 2005-09-02 2008-08-06 Genzyme Corporation Method for removing phosphate and polymer used therefore
EP1924246B1 (en) 2005-09-15 2015-10-21 Genzyme Corporation Sachet formulation for amine polymers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5879022A (en) * 1981-11-04 1983-05-12 Bitamin Kenkyusho:Kk Novel metal-crosslinked polymer compound containing quaternary nitrogen atom, its preparation, and remedy for hyperlipemia containing said polymer compound as active component

Also Published As

Publication number Publication date
DE2946026A1 (en) 1980-07-10
GB2036048B (en) 1983-05-05
IT7950802A0 (en) 1979-11-12
GB2036048A (en) 1980-06-25
FR2441639A1 (en) 1980-06-13

Similar Documents

Publication Publication Date Title
JPS5566513A (en) Drug for arteriosclerosis comprising high polymer compound as active constituent
EP0226441A3 (en) Preparation of pharmaceutical compositions for the treatment of hypoxia
EP0411150A4 (en) Indole derivatives, preparation thereof, and drug for preventing and treating nephritis containing same
MY130555A (en) Super absorbent polymer composition
IE810221L (en) Aromatic aminoethanol compounds, adrenergic blocking agents
EP0340754A3 (en) Monopersulfates of amino-(poly) percarboxylic acids
ATE175115T1 (en) ANTIVIRAL COMPOSITIONS AND METHODS OF USE THEREOF
EP0047491A3 (en) New cephem compounds and processes for preparation thereof
EP0128007A3 (en) Phenyl tetrahydronaphthylcarboxylate derivatives
IE870440L (en) Fungicidal compositions
CA2038025A1 (en) Optically active alkylenedioxybenzene derivatives and their use in therapy
HU903092D0 (en) Process for the preparation of buten-carboxylic acid derivatives and pharmaceutical compositions containing such compounds
WO1990012577A3 (en) Topical anti-angiogenic as hair growth inhibitors
KR850005228A (en) Aminoalkanosephosphonic acid and its derivatives as fungicides
HUT42426A (en) Process for preparing /4.2.0/bicyclooctane derivatives and pharmaceutical compositions containing such active substances
FI80878B (en) FOERFARANDE FOER FRAMSTAELLNING AV FARMAKOLOGISKT ANVAENDBARA -ARYL- -PYRIDYLALKANSYRADERIVAT.
IE801789L (en) Nitrosourea derivatives.
AU582206B2 (en) Imidazole derivatives,their preparation and therapeutic use
IE782005L (en) Pharmaceutical compositions
JPS56145300A (en) N2-pyridyl-2,6-diaminonebularine
DE3175939D1 (en) Use of gamma-piperidino-butyrophenones for the preparation of medicaments for treating diarrhoea
JPS5746915A (en) Antiallergic agent
EP0370712A3 (en) Ethylamine derivatives and hypotensives containing the same
CA2132017A1 (en) Imidazolin Derivatives and a Method for Producing the Same and a Therapeutic Agent for Maintaining Blood Pressure
JPS5677219A (en) Novel hair rinse composition