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JPS5549372A - Production of macrocyclic lactone - Google Patents

Production of macrocyclic lactone

Info

Publication number
JPS5549372A
JPS5549372A JP12263878A JP12263878A JPS5549372A JP S5549372 A JPS5549372 A JP S5549372A JP 12263878 A JP12263878 A JP 12263878A JP 12263878 A JP12263878 A JP 12263878A JP S5549372 A JPS5549372 A JP S5549372A
Authority
JP
Japan
Prior art keywords
compound
reaction
chained
formula
long
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12263878A
Other languages
Japanese (ja)
Other versions
JPS6111231B2 (en
Inventor
Mitsuaki Mukoyama
Koichi Narasaka
Kazuo Maruyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
Shingijutsu Kaihatsu Jigyodan
Original Assignee
Research Development Corp of Japan
Shingijutsu Kaihatsu Jigyodan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Development Corp of Japan, Shingijutsu Kaihatsu Jigyodan filed Critical Research Development Corp of Japan
Priority to JP12263878A priority Critical patent/JPS5549372A/en
Publication of JPS5549372A publication Critical patent/JPS5549372A/en
Publication of JPS6111231B2 publication Critical patent/JPS6111231B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: The reaction of a long-chained hydroxycarboxylic acid with 2-chloro- 6-methyl-1, 3-diphenylpyridinium borofluoride gives title compound in one step and high yield with no use of harmful substance, said compound is useful as an intermediate of perfume and drug.
CONSTITUTION: The reaction between a long-chained hydroxycarboxylic acid of the formula: HO-X-COOH (X is a long-chained compound of 8 or more carbon atoms which may be substituted with alkyl, aralkyl or cyclic substituent and may contain unsaturated bond, carbonyl, halogen, etc.) and 2-chloro-6-methyl-1, 3- diphenylpyridinium borofluoride of formula I is conducted in an inert solvent to give title compound of formula II. The presence of a tertiary amine and tetraalkylammonium chloride acclerates the reaction and the reaction temperature is room one W80°C.
USE: Said compound has the base skelton of macrolides that is used as remedy for staphylomycosis and streptomycosis.
COPYRIGHT: (C)1980,JPO&Japio
JP12263878A 1978-10-06 1978-10-06 Production of macrocyclic lactone Granted JPS5549372A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12263878A JPS5549372A (en) 1978-10-06 1978-10-06 Production of macrocyclic lactone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12263878A JPS5549372A (en) 1978-10-06 1978-10-06 Production of macrocyclic lactone

Publications (2)

Publication Number Publication Date
JPS5549372A true JPS5549372A (en) 1980-04-09
JPS6111231B2 JPS6111231B2 (en) 1986-04-01

Family

ID=14840916

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12263878A Granted JPS5549372A (en) 1978-10-06 1978-10-06 Production of macrocyclic lactone

Country Status (1)

Country Link
JP (1) JPS5549372A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6488472B2 (en) 2013-09-30 2019-03-27 パテオン エーピーアイ サービシーズ インコーポレイテッドＰａｔｈｅｏｎ Ａｐｉ Ｓｅｒｖｉｃｅｓ Ｉｎｃ． A new synthetic route to prostaglandins and prostaglandin intermediates using metathesis

Also Published As

Publication number Publication date
JPS6111231B2 (en) 1986-04-01

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