JPS5535066A - Novel pyrazole derivative - Google Patents
Novel pyrazole derivativeInfo
- Publication number
- JPS5535066A JPS5535066A JP10926978A JP10926978A JPS5535066A JP S5535066 A JPS5535066 A JP S5535066A JP 10926978 A JP10926978 A JP 10926978A JP 10926978 A JP10926978 A JP 10926978A JP S5535066 A JPS5535066 A JP S5535066A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- lower alkyl
- compound
- alkyl group
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A pyrazole derivative of formula I: (R1 and R2 are H, lower alkyl, or aryl groups; R3 is H or lower alkyl group).
EXAMPLE: Ethyl 4-(5-hydroxy-1-phenyl pyrazol-4-yl)-2,4-dioxobutyrate.
USE: Medicines, e.g. antirheumatics, antiallergic agents, and anti-cancer drugs, having immuno adjusting actions.
PROCESS: An acetyl derivative of formula II is reacted with a compound of formula III in a solvent, e.g. benzene, in the presence of a basic catalyst at 30W100°C for 30minW6hr to give the title compound of formula I wherein R3 is a lower alkyl group. Potassium carbonate or hydroxide may be cited as the catalyst. The compound of formula I is present in the form of several kato-enol tautomers. The carboxylic acid derivertive of the compound of formula I wherein R3 is H is obtained by hydrolyzing the ester derivative of formula I wherein R3 is a lower alkyl group with an acid or alkali.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10926978A JPS5535066A (en) | 1978-09-05 | 1978-09-05 | Novel pyrazole derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10926978A JPS5535066A (en) | 1978-09-05 | 1978-09-05 | Novel pyrazole derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5535066A true JPS5535066A (en) | 1980-03-11 |
Family
ID=14505880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10926978A Pending JPS5535066A (en) | 1978-09-05 | 1978-09-05 | Novel pyrazole derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5535066A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5785357A (en) * | 1980-09-11 | 1982-05-28 | Zoecon Corp | Manufacture of oxyiminonitrile |
| EP1083897A4 (en) * | 1998-06-03 | 2003-01-02 | Merck & Co Inc | Hiv integrase inhibitors |
-
1978
- 1978-09-05 JP JP10926978A patent/JPS5535066A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5785357A (en) * | 1980-09-11 | 1982-05-28 | Zoecon Corp | Manufacture of oxyiminonitrile |
| EP1083897A4 (en) * | 1998-06-03 | 2003-01-02 | Merck & Co Inc | Hiv integrase inhibitors |
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