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JPS5535018A - Alkaneamide derivative - Google Patents

Alkaneamide derivative

Info

Publication number
JPS5535018A
JPS5535018A JP10786878A JP10786878A JPS5535018A JP S5535018 A JPS5535018 A JP S5535018A JP 10786878 A JP10786878 A JP 10786878A JP 10786878 A JP10786878 A JP 10786878A JP S5535018 A JPS5535018 A JP S5535018A
Authority
JP
Japan
Prior art keywords
derivative
agent
antiphlogistic
reacted
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10786878A
Other languages
Japanese (ja)
Other versions
JPS6136515B2 (en
Inventor
Minoru Uchida
Takao Nishi
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP10786878A priority Critical patent/JPS5535018A/en
Publication of JPS5535018A publication Critical patent/JPS5535018A/en
Publication of JPS6136515B2 publication Critical patent/JPS6136515B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

NEW MATERIAL:An alkaneamide derivative I (R1 is lower alkyl; R2 is cycloalkyl; A is methylene or carbonyl; n is integer of 1-3).
EXAMPLE: N-methyl-N-cyclohexyl-5-[6-(3, 4-dihydrocarbostyryl)]-butyrylamide.
USE: Antithrombic agent, antiphlogistic, antiulceration agent and antiasthmatic agent. Blood platelet-coagulation suppressing, antiphlogistic and phosphodiesterase-hindering actions.
PROCESS: For example, a carboxylic acid derivative II is reacted with an amine derivative to give the desired compound I. The mixed acid anhydride mathod may be used for the reaction. That is, the mixed acid anhydride prepared by reacting a carboxylic acid II with an alkylhalocarboxylic acid, is reacted with an amine III.
COPYRIGHT: (C)1980,JPO&Japio
JP10786878A 1978-09-01 1978-09-01 Alkaneamide derivative Granted JPS5535018A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10786878A JPS5535018A (en) 1978-09-01 1978-09-01 Alkaneamide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10786878A JPS5535018A (en) 1978-09-01 1978-09-01 Alkaneamide derivative

Publications (2)

Publication Number Publication Date
JPS5535018A true JPS5535018A (en) 1980-03-11
JPS6136515B2 JPS6136515B2 (en) 1986-08-19

Family

ID=14470108

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10786878A Granted JPS5535018A (en) 1978-09-01 1978-09-01 Alkaneamide derivative

Country Status (1)

Country Link
JP (1) JPS5535018A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3324034A1 (en) * 1982-07-05 1984-01-05 Otsuka Pharmaceutical Co. Ltd., Tokyo CARBOSTYRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THEM
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS511481A (en) * 1974-06-24 1976-01-08 Otsuka Pharma Co Ltd KARUBOKISHIARUKOKISHI 3 * 44 JIHIDOROKARUBOSUCHIRIRUJUDOTAINO SEIZOHO
JPS5123271A (en) * 1974-08-16 1976-02-24 Otsuka Pharma Co Ltd KARUBAMOIRUARUKOKISHI 3 * 44 JIHIDOROKARUBOSUCHIRU JUDOTAISEIZOHO
JPS5273875A (en) * 1975-12-16 1977-06-21 Otsuka Pharmaceut Co Ltd Synthesis of carbostyril-carboxylic acid derivatives
JPS5273878A (en) * 1975-12-18 1977-06-21 Otsuka Pharmaceut Co Ltd Synthesis of 6-carboxyacetyl-3,4-dihydrocarbostyril
JPS5273879A (en) * 1975-12-18 1977-06-21 Otsuka Pharmaceut Co Ltd Synthesis of ester derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS511481A (en) * 1974-06-24 1976-01-08 Otsuka Pharma Co Ltd KARUBOKISHIARUKOKISHI 3 * 44 JIHIDOROKARUBOSUCHIRIRUJUDOTAINO SEIZOHO
JPS5123271A (en) * 1974-08-16 1976-02-24 Otsuka Pharma Co Ltd KARUBAMOIRUARUKOKISHI 3 * 44 JIHIDOROKARUBOSUCHIRU JUDOTAISEIZOHO
JPS5273875A (en) * 1975-12-16 1977-06-21 Otsuka Pharmaceut Co Ltd Synthesis of carbostyril-carboxylic acid derivatives
JPS5273878A (en) * 1975-12-18 1977-06-21 Otsuka Pharmaceut Co Ltd Synthesis of 6-carboxyacetyl-3,4-dihydrocarbostyril
JPS5273879A (en) * 1975-12-18 1977-06-21 Otsuka Pharmaceut Co Ltd Synthesis of ester derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3324034A1 (en) * 1982-07-05 1984-01-05 Otsuka Pharmaceutical Co. Ltd., Tokyo CARBOSTYRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THEM
DE3324034C2 (en) * 1982-07-05 1993-07-01 Otsuka Pharmaceutical Co., Ltd., Tokio/Tokyo, Jp
USRE34722E (en) * 1982-07-05 1994-09-06 Otsuka Pharmaceutical Co., Ltd. Quinoline amino acid derivatives of carbostyril compounds
WO1989010919A1 (en) 1988-05-02 1989-11-16 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Also Published As

Publication number Publication date
JPS6136515B2 (en) 1986-08-19

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