JPS55164664A - Preparation of beta-chlorolactonitrile - Google Patents
Preparation of beta-chlorolactonitrileInfo
- Publication number
- JPS55164664A JPS55164664A JP7116779A JP7116779A JPS55164664A JP S55164664 A JPS55164664 A JP S55164664A JP 7116779 A JP7116779 A JP 7116779A JP 7116779 A JP7116779 A JP 7116779A JP S55164664 A JPS55164664 A JP S55164664A
- Authority
- JP
- Japan
- Prior art keywords
- chloroacetaldehyde
- water
- ammonium salt
- salt
- chlorolactonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RDXMEUDCEWSFDP-UHFFFAOYSA-N 3-chloro-2-hydroxypropanenitrile Chemical compound ClCC(O)C#N RDXMEUDCEWSFDP-UHFFFAOYSA-N 0.000 title abstract 2
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 abstract 4
- 150000003863 ammonium salts Chemical class 0.000 abstract 3
- FOSJCKHMFVJVKH-UHFFFAOYSA-N 2-chloroacetaldehyde;sulfurous acid Chemical compound OS(O)=O.ClCC=O FOSJCKHMFVJVKH-UHFFFAOYSA-N 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 239000000047 product Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- QSKPIOLLBIHNAC-UHFFFAOYSA-N 2-chloro-acetaldehyde Chemical compound ClCC=O QSKPIOLLBIHNAC-UHFFFAOYSA-N 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003905 agrochemical Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- -1 lithium or sodium Chemical class 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound useful as an active constituent of a medicine and an agricultural chemical industrially advantageously, by reacting an aqueous solution of chloroacetaldehyde bisulfite addition product with hydrocyanic acid or a cyanide in the presence of an ammonium salt.
CONSTITUTION: Chloroacetaldehyde (C) is reacted with a bisulfite, e.g. a water- soluble salt such as lithium or sodium, in water to give a chloroacetaldehyde bisulfite addition product, which is dissolved in water to form an aqueous solution. An ammonium salt, preferably a salt of a mineral acid such as hydrochloric, sulfuric or nitric acid, in a molar amount of 1W2 times that of (C), is added to the solution, and hydrocyanic acid or a cyanide is reacted with (C) at a low temperature of about -10W10°C under cooling to give β-chlorolactonitrile.
EFFECT: The use of the ammonium salt is indispensable to the inhibition of by- product formation and prevention of polymerization.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7116779A JPS55164664A (en) | 1979-06-08 | 1979-06-08 | Preparation of beta-chlorolactonitrile |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7116779A JPS55164664A (en) | 1979-06-08 | 1979-06-08 | Preparation of beta-chlorolactonitrile |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55164664A true JPS55164664A (en) | 1980-12-22 |
| JPS5761353B2 JPS5761353B2 (en) | 1982-12-23 |
Family
ID=13452813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7116779A Granted JPS55164664A (en) | 1979-06-08 | 1979-06-08 | Preparation of beta-chlorolactonitrile |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55164664A (en) |
-
1979
- 1979-06-08 JP JP7116779A patent/JPS55164664A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5761353B2 (en) | 1982-12-23 |
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