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JPS55151561A - Isonicotinic acid hydrazide derivatives and their preparation - Google Patents

Isonicotinic acid hydrazide derivatives and their preparation

Info

Publication number
JPS55151561A
JPS55151561A JP6088579A JP6088579A JPS55151561A JP S55151561 A JPS55151561 A JP S55151561A JP 6088579 A JP6088579 A JP 6088579A JP 6088579 A JP6088579 A JP 6088579A JP S55151561 A JPS55151561 A JP S55151561A
Authority
JP
Japan
Prior art keywords
acid hydrazide
isonicotinic acid
substituted
preparation
hydrazide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6088579A
Other languages
Japanese (ja)
Other versions
JPS6058911B2 (en
Inventor
Shigeru Yamabe
Junichi Yamashita
Sadao Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP6088579A priority Critical patent/JPS6058911B2/en
Publication of JPS55151561A publication Critical patent/JPS55151561A/en
Publication of JPS6058911B2 publication Critical patent/JPS6058911B2/en
Expired legal-status Critical Current

Links

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  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Isonicotinic acid hydrazide derivatives of the formula (R is lower dialkylamino, cyclic amino which may be substituted with hydroxyl or piperazino which may be substituted with lower alkyl).
EXAMPLE: 2-(4-Methyl-1-piperazinylsulfonyl)benzalisonicotinylhydrazone.
USE: They show high antibacterial activity against pathogenic bacteria, especially TB, thus being used as remedy for tuberculosis with low toxicity.
PREPARATION: o-Formylbenzenesulfonyl halide is made to react with a secondary amine selected from hydroxyl-substituted or unsubstituted lower dialkylamines or cyclic amines in a solvent such as chloroform at 10W30°C. Then, the product is made to react with isonicotinic acid hydrazide to give the compound of the formula.
COPYRIGHT: (C)1980,JPO&Japio
JP6088579A 1979-05-16 1979-05-16 Isonicotinic acid hydrazide derivative and method for producing the same Expired JPS6058911B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6088579A JPS6058911B2 (en) 1979-05-16 1979-05-16 Isonicotinic acid hydrazide derivative and method for producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6088579A JPS6058911B2 (en) 1979-05-16 1979-05-16 Isonicotinic acid hydrazide derivative and method for producing the same

Publications (2)

Publication Number Publication Date
JPS55151561A true JPS55151561A (en) 1980-11-26
JPS6058911B2 JPS6058911B2 (en) 1985-12-23

Family

ID=13155264

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6088579A Expired JPS6058911B2 (en) 1979-05-16 1979-05-16 Isonicotinic acid hydrazide derivative and method for producing the same

Country Status (1)

Country Link
JP (1) JPS6058911B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764290A1 (en) * 1997-06-04 1998-12-11 Nihon Bayer Agrochem Kk HYDRAZIDE DERIVATIVES OF ISONICOTINIC ACID

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764290A1 (en) * 1997-06-04 1998-12-11 Nihon Bayer Agrochem Kk HYDRAZIDE DERIVATIVES OF ISONICOTINIC ACID

Also Published As

Publication number Publication date
JPS6058911B2 (en) 1985-12-23

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