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JPS55133394A - Novel aminosaccharide antibiotic g-367-1 and its preparation - Google Patents

Novel aminosaccharide antibiotic g-367-1 and its preparation

Info

Publication number
JPS55133394A
JPS55133394A JP4127479A JP4127479A JPS55133394A JP S55133394 A JPS55133394 A JP S55133394A JP 4127479 A JP4127479 A JP 4127479A JP 4127479 A JP4127479 A JP 4127479A JP S55133394 A JPS55133394 A JP S55133394A
Authority
JP
Japan
Prior art keywords
aminosaccharide
antibiotic
novel
preparation
negative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4127479A
Other languages
Japanese (ja)
Other versions
JPS6126914B2 (en
Inventor
Tadayo Fujii
Shuzo Satoi
Naoki Muto
Mitsuo Hayashi
Akira Kodama
Masaru Kotani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP4127479A priority Critical patent/JPS55133394A/en
Priority to US06/137,292 priority patent/US4297486A/en
Priority to DE19803013210 priority patent/DE3013210A1/en
Priority to FR8007574A priority patent/FR2452932A1/en
Priority to GB8011265A priority patent/GB2053895B/en
Priority to CA000349243A priority patent/CA1140877A/en
Priority to CH5618/80A priority patent/CH648855A5/en
Priority to BE0/201867A priority patent/BE884925A/en
Publication of JPS55133394A publication Critical patent/JPS55133394A/en
Publication of JPS6126914B2 publication Critical patent/JPS6126914B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C12P19/485—Having two saccharide radicals bound through only oxygen to non-adjacent ring carbons of the cyclohexyl radical, e.g. gentamycin, kanamycin, sisomycin, verdamycin, mutamycin, tobramycin, nebramycin, antibiotics 66-40B, 66-40D, XK-62-2, 66-40, G-418, G-52
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

NEW MATERIAL:Aminosaccharide antibiotic G-367-1 (nontoxic acid addition salt) having the following physico-chemical properties: Melting point 130W133°C. [α]D24+188.9° (C=1.0, H2O). C, 50.14%; H, 7.60%; N, 14.42%. Molecular weight 475(mass spectrometry). Molecular formula C20H37N5O8. Soluble in water and methanol; insoluble in acetone, benzene, chloroform, etc. Positive to ninhydrin and KMnO4 decoloration reactions; negative to the biuret reaction. Basic.
USE: Antibacterials having a great activity particularly against Gram-negative bacteria.
PROCESS: G-367-1 producing actinomycetes, (FERM-P No. 4840), which belong to the genus Dactylosporangium, are incubated in a medium aerobically at 25W35°C for 100W200hr.
COPYRIGHT: (C)1980,JPO&Japio
JP4127479A 1979-04-04 1979-04-04 Novel aminosaccharide antibiotic g-367-1 and its preparation Granted JPS55133394A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP4127479A JPS55133394A (en) 1979-04-04 1979-04-04 Novel aminosaccharide antibiotic g-367-1 and its preparation
US06/137,292 US4297486A (en) 1979-04-04 1980-04-03 Aminoglycoside antibiotic G-367-1 and method for the production thereof
DE19803013210 DE3013210A1 (en) 1979-04-04 1980-04-03 NEW AMINOGLYCOSIDE ANTIBIOTICS AND METHOD FOR THEIR PRODUCTION
FR8007574A FR2452932A1 (en) 1979-04-04 1980-04-03 NOVEL AMINOGLYCOSIDE ANTIBIOTICS AND THEIR PRODUCTION
GB8011265A GB2053895B (en) 1979-04-04 1980-04-03 Aminoglycoside antibiotics and their production
CA000349243A CA1140877A (en) 1979-04-04 1980-04-03 Aminoglycoside antibiotics and production thereof
CH5618/80A CH648855A5 (en) 1979-04-04 1980-07-23 Aminoglycoside antibiotics and process for their preparation
BE0/201867A BE884925A (en) 1979-04-04 1980-08-26 NOVEL AMINOGLYCOSIDE ANTIBIOTIC AND METHOD FOR THE PRODUCTION THEREOF.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4127479A JPS55133394A (en) 1979-04-04 1979-04-04 Novel aminosaccharide antibiotic g-367-1 and its preparation

Publications (2)

Publication Number Publication Date
JPS55133394A true JPS55133394A (en) 1980-10-17
JPS6126914B2 JPS6126914B2 (en) 1986-06-23

Family

ID=12603856

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4127479A Granted JPS55133394A (en) 1979-04-04 1979-04-04 Novel aminosaccharide antibiotic g-367-1 and its preparation

Country Status (4)

Country Link
JP (1) JPS55133394A (en)
BE (1) BE884925A (en)
CH (1) CH648855A5 (en)
DE (1) DE3013210A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907771A (en) * 1971-02-03 1975-09-23 Schering Corp Antibiotic 66-40
US3920628A (en) * 1972-10-24 1975-11-18 Schering Corp 2{41 -Deoxyaminoglycosides and 2{41 -epi-amino-3{41 -desamino derivatives thereof, methods for their manufacture and novel intermediates useful therein
EP0000473B1 (en) * 1977-06-24 1981-03-11 Scherico Ltd. Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives

Also Published As

Publication number Publication date
JPS6126914B2 (en) 1986-06-23
DE3013210A1 (en) 1980-11-20
CH648855A5 (en) 1985-04-15
BE884925A (en) 1980-12-16

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