JPS55129220A - Composition for solid preparation containing hardly soluble medicinal component having rapid action and high bioavailability - Google Patents
Composition for solid preparation containing hardly soluble medicinal component having rapid action and high bioavailabilityInfo
- Publication number
- JPS55129220A JPS55129220A JP1441280A JP1441280A JPS55129220A JP S55129220 A JPS55129220 A JP S55129220A JP 1441280 A JP1441280 A JP 1441280A JP 1441280 A JP1441280 A JP 1441280A JP S55129220 A JPS55129220 A JP S55129220A
- Authority
- JP
- Japan
- Prior art keywords
- hardly soluble
- composition
- medicinal component
- polyvinyl pyrrolidone
- preparation containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 abstract 1
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 abstract 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 235000013877 carbamide Nutrition 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 abstract 1
- 229960002867 griseofulvin Drugs 0.000 abstract 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 229960000905 indomethacin Drugs 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 abstract 1
- 229960003464 mefenamic acid Drugs 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- 235000010981 methylcellulose Nutrition 0.000 abstract 1
- -1 rifampicillin Chemical compound 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To prepare the title composition by compounding a hardly soluble medicinal component with a specific base component such as polyvinyl pyrrolidone and polyethylene glycol.
CONSTITUTION: A hardly soluble medicine, e.g. γ-oryzanol, indomethacin, rifampicillin, griseofulvin, and mefenamic acid, is compounded with either (A) a composition containing polyvinyl pyrrolidone, methyl cellulose, hydroxypropyl cellulose, and/or hydroxypropyl methyl cellulose (the 1-a component) or (B) a mixture of (a) a composition containing one or more compounds selected from polyvinyl pyrrolidone, urea, citric acid, mannitol, etc. and (b) one or more compounds selected from a surface active agent, polyethylene glycol, propylene glycol, glycerine, etc., and the mixture is granulated sith a fluid bed granulator.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1441280A JPS55129220A (en) | 1980-02-08 | 1980-02-08 | Composition for solid preparation containing hardly soluble medicinal component having rapid action and high bioavailability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1441280A JPS55129220A (en) | 1980-02-08 | 1980-02-08 | Composition for solid preparation containing hardly soluble medicinal component having rapid action and high bioavailability |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53152313 Division |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS55129220A true JPS55129220A (en) | 1980-10-06 |
Family
ID=11860318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1441280A Pending JPS55129220A (en) | 1980-02-08 | 1980-02-08 | Composition for solid preparation containing hardly soluble medicinal component having rapid action and high bioavailability |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55129220A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008709A1 (en) * | 1992-10-09 | 1994-04-28 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Production method for fine granulate |
| WO2006085089A1 (en) * | 2005-02-10 | 2006-08-17 | Pharmaterials Limited | Solid dispersion of hydrophobic bioactive |
| JP2006335767A (en) * | 1999-09-17 | 2006-12-14 | Novartis Ag | Methods for treating metabolic disorders, especially diabetes, or diabetes-related diseases or conditions |
| US8074577B2 (en) | 2006-11-10 | 2011-12-13 | Mitsubishi Heavy Industries, Ltd. | Structure of bifurvation and crossover site of guideway in guided vehicle transportation system |
-
1980
- 1980-02-08 JP JP1441280A patent/JPS55129220A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008709A1 (en) * | 1992-10-09 | 1994-04-28 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Production method for fine granulate |
| US5547683A (en) * | 1992-10-09 | 1996-08-20 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Method for producing microgranulated particle |
| JP2006335767A (en) * | 1999-09-17 | 2006-12-14 | Novartis Ag | Methods for treating metabolic disorders, especially diabetes, or diabetes-related diseases or conditions |
| WO2006085089A1 (en) * | 2005-02-10 | 2006-08-17 | Pharmaterials Limited | Solid dispersion of hydrophobic bioactive |
| US8074577B2 (en) | 2006-11-10 | 2011-12-13 | Mitsubishi Heavy Industries, Ltd. | Structure of bifurvation and crossover site of guideway in guided vehicle transportation system |
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