JPS55111465A - Prostaglandin i2 analog and its preparation - Google Patents

Prostaglandin i2 analog and its preparation

Info

Publication number: JPS55111465A
Authority: JP; Japan
Prior art keywords: compound; formula; group; alkyl group; substituted
Prior art date: 1979-02-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP1793579A

Other languages

English (en)

Other versions

JPS6228134B2 (ja

Inventor

Hirohisa Wakatsuka

Yoshitaka Konishi

Masaki Hayashi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ono Pharmaceutical Co Ltd

Original Assignee

Ono Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-02-20

Filing date

1979-02-20

Publication date

1980-08-28

1979-02-20 Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd

1979-02-20 Priority to JP1793579A priority Critical patent/JPS55111465A/ja

1980-02-18 Priority to AU55625/80A priority patent/AU540973B2/en

1980-02-18 Priority to ZA00800921A priority patent/ZA80921B/xx

1980-02-18 Priority to DE19803006032 priority patent/DE3006032A1/de

1980-02-18 Priority to NL8000987A priority patent/NL8000987A/nl

1980-02-18 Priority to HU80368A priority patent/HU184239B/hu

1980-02-18 Priority to IT19983/80A priority patent/IT1141221B/it

1980-02-18 Priority to GB8005439A priority patent/GB2044763B/en

1980-02-18 Priority to CA000345900A priority patent/CA1154442A/en

1980-02-18 Priority to IE297/80A priority patent/IE49512B1/en

1980-02-19 Priority to BE0/199455A priority patent/BE881799A/fr

1980-02-19 Priority to LU82182A priority patent/LU82182A1/fr

1980-02-19 Priority to CH133580A priority patent/CH646152A5/fr

1980-02-19 Priority to US06/122,704 priority patent/US4313954A/en

1980-02-19 Priority to FR8003580A priority patent/FR2449680A1/fr

1980-08-28 Publication of JPS55111465A publication Critical patent/JPS55111465A/ja

1987-06-18 Publication of JPS6228134B2 publication Critical patent/JPS6228134B2/ja

Status Granted legal-status Critical Current

Links

150000003174 prostaglandin I2 derivatives Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
239000002253 acid Substances 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
-1 (substituted) phenyl group Chemical group 0.000 abstract 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
239000005977 Ethylene Substances 0.000 abstract 1
208000008469 Peptic Ulcer Diseases 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
150000001540 azides Chemical class 0.000 abstract 1
229940124558 contraceptive agent Drugs 0.000 abstract 1
239000003433 contraceptive agent Substances 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
239000000411 inducer Substances 0.000 abstract 1
230000009027 insemination Effects 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
230000005906 menstruation Effects 0.000 abstract 1
150000004702 methyl esters Chemical class 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
208000011906 peptic ulcer disease Diseases 0.000 abstract 1
230000002093 peripheral effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

JP1793579A 1979-02-20 1979-02-20 Prostaglandin i2 analog and its preparation Granted JPS55111465A (en)

Priority Applications (15)

Application Number	Priority Date	Filing Date	Title
JP1793579A JPS55111465A (en)	1979-02-20	1979-02-20	Prostaglandin i2 analog and its preparation
AU55625/80A AU540973B2 (en)	1979-02-20	1980-02-18	6,9-nitrilo - prostaglandin analogues
ZA00800921A ZA80921B (en)	1979-02-20	1980-02-18	6,9-nitrilo-prostaglandin analogues
DE19803006032 DE3006032A1 (de)	1979-02-20	1980-02-18	6,9-nitrilo-prostaglandin-analoge
NL8000987A NL8000987A (nl)	1979-02-20	1980-02-18	6.9-nitrilo-prostaglandine analoge verbindingen.
HU80368A HU184239B (en)	1979-02-20	1980-02-18	Process for preparing 6,9-nitrilo-prostaglandin analogues
IT19983/80A IT1141221B (it)	1979-02-20	1980-02-18	Analoghi della 6.9-nitrilo-prostaglandina
GB8005439A GB2044763B (en)	1979-02-20	1980-02-18	6,9 - nitrilo - prostaglandin analogues
CA000345900A CA1154442A (en)	1979-02-20	1980-02-18	6,9-nitrilo-prostaglandin analogues
IE297/80A IE49512B1 (en)	1979-02-20	1980-02-18	6,9-nitrilo-prostaglandin analogues
BE0/199455A BE881799A (fr)	1979-02-20	1980-02-19	Analogues de la protaglandine i2 et compositions pharmaceutiques les contenant
LU82182A LU82182A1 (fr)	1979-02-20	1980-02-19	Analogues de la prostaglandine i2 et les compositions pharmaceutiques les contenant
CH133580A CH646152A5 (fr)	1979-02-20	1980-02-19	Analogues de la prostaglandine et compositions pharmaceutiques les contenant.
US06/122,704 US4313954A (en)	1979-02-20	1980-02-19	6,9-Nitrilo-prostaglandin analogues
FR8003580A FR2449680A1 (fr)	1979-02-20	1980-02-19	Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP1793579A JPS55111465A (en)	1979-02-20	1979-02-20	Prostaglandin i2 analog and its preparation

Publications (2)

Publication Number	Publication Date
JPS55111465A true JPS55111465A (en)	1980-08-28
JPS6228134B2 JPS6228134B2 (ja)	1987-06-18

Family

ID=11957625

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP1793579A Granted JPS55111465A (en)	1979-02-20	1979-02-20	Prostaglandin i2 analog and its preparation

Country Status (15)

Country	Link
US (1)	US4313954A (ja)
JP (1)	JPS55111465A (ja)
AU (1)	AU540973B2 (ja)
BE (1)	BE881799A (ja)
CA (1)	CA1154442A (ja)
CH (1)	CH646152A5 (ja)
DE (1)	DE3006032A1 (ja)
FR (1)	FR2449680A1 (ja)
GB (1)	GB2044763B (ja)
HU (1)	HU184239B (ja)
IE (1)	IE49512B1 (ja)
IT (1)	IT1141221B (ja)
LU (1)	LU82182A1 (ja)
NL (1)	NL8000987A (ja)
ZA (1)	ZA80921B (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58203911A (ja) *	1982-05-25	1983-11-28	Ono Pharmaceut Co Ltd	プロスタグランジン類似化合物を有効成分として含有する細肪障害治療剤
JPS6130519A (ja) *	1984-07-23	1986-02-12	Dainippon Pharmaceut Co Ltd	脳神経細胞の酸素欠乏性疾患治療剤
DE102014200866A1 (de) *	2014-01-17	2015-07-23	Iwa - F. Riehle Gmbh & Co Kg	Vorrichtung zur Ermittlung einer zu spritzenden Insulinmenge bei Diabetes-Patienten

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS549265A (en) *	1977-06-17	1979-01-24	Upjohn Co	Composition and method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS54125653A (en) *	1978-03-18	1979-09-29	Ono Pharmaceut Co Ltd	Prostaglandin i2 analog, its preparation, and drug composition comprising it as active constituent
US4211706A (en) *	1978-10-13	1980-07-08	The Upjohn Company	9-Deoxy-9α,6-nitrilo or 6,9α-imino-17,18-didehydro-PGF compounds

1979
- 1979-02-20 JP JP1793579A patent/JPS55111465A/ja active Granted
1980
- 1980-02-18 CA CA000345900A patent/CA1154442A/en not_active Expired
- 1980-02-18 IE IE297/80A patent/IE49512B1/en unknown
- 1980-02-18 GB GB8005439A patent/GB2044763B/en not_active Expired
- 1980-02-18 NL NL8000987A patent/NL8000987A/nl not_active Application Discontinuation
- 1980-02-18 HU HU80368A patent/HU184239B/hu not_active IP Right Cessation
- 1980-02-18 IT IT19983/80A patent/IT1141221B/it active
- 1980-02-18 ZA ZA00800921A patent/ZA80921B/xx unknown
- 1980-02-18 DE DE19803006032 patent/DE3006032A1/de active Granted
- 1980-02-18 AU AU55625/80A patent/AU540973B2/en not_active Ceased
- 1980-02-19 CH CH133580A patent/CH646152A5/fr not_active IP Right Cessation
- 1980-02-19 US US06/122,704 patent/US4313954A/en not_active Expired - Lifetime
- 1980-02-19 LU LU82182A patent/LU82182A1/fr unknown
- 1980-02-19 FR FR8003580A patent/FR2449680A1/fr active Granted
- 1980-02-19 BE BE0/199455A patent/BE881799A/fr not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS549265A (en) *	1977-06-17	1979-01-24	Upjohn Co	Composition and method

Also Published As

Publication number	Publication date
HU184239B (en)	1984-07-30
US4313954A (en)	1982-02-02
IT8019983A0 (it)	1980-02-18
IE800297L (en)	1980-08-20
DE3006032A1 (de)	1980-08-28
FR2449680A1 (fr)	1980-09-19
GB2044763B (en)	1983-02-23
DE3006032C2 (ja)	1988-03-17
LU82182A1 (fr)	1980-09-24
AU5562580A (en)	1980-08-28
AU540973B2 (en)	1984-12-13
NL8000987A (nl)	1980-08-22
ZA80921B (en)	1981-02-25
CA1154442A (en)	1983-09-27
GB2044763A (en)	1980-10-22
FR2449680B1 (ja)	1983-04-15
IE49512B1 (en)	1985-10-16
BE881799A (fr)	1980-08-19
CH646152A5 (fr)	1984-11-15
IT1141221B (it)	1986-10-01
JPS6228134B2 (ja)	1987-06-18

Publication	Publication Date	Title
US4158667A (en)	1979-06-19	6-Keto PGF analogs
ZA88317B (en)	1988-07-27	New 11-aryl steroid derivatives
JPS56158760A (en)	1981-12-07	Prostaglandin analog compound, its preparation and drug composition containing the same
US4013695A (en)	1977-03-22	4,4,5,5-Tetradehydro-PGE1 analogs
JPS51149247A (en)	1976-12-22	Prostaglandin analogues, process for their preparation and drug compos itions containing them as effective ingredients
JPS55111465A (en)	1980-08-28	Prostaglandin i2 analog and its preparation
JPS5395958A (en)	1978-08-22	Prostaglandin analogues and process for their preparation
US3904679A (en)	1975-09-09	15-Methyl and 15-ethyl prostaglandin F{HD 2{331 {0 {B analogs
IL59479A0 (en)	1980-05-30	New 7-alkylated steroid derivatives,process for preparing them, their use as a medicament and the pharmaceutical compositions containing them
US4292445A (en)	1981-09-29	Amide and sulfonamide derivatives of 2-decarboxy-2-aminomethyl-PG-type compounds
JPS5419946A (en)	1979-02-15	Prostaglandin analog compound and their preparation
GB1430995A (en)	1976-04-07	13-cis-prostaglandin derivatives and their preparation
GB1473670A (en)	1977-05-18	Process for the manufacture of prostaglandin-f2a and analogues thereof
JPS5414998A (en)	1979-02-03	Prostaglandin i2 analog and its preparation
JPS5589297A (en)	1980-07-05	Prostaglandin derivative, its preparation and its drug
JPS5236646A (en)	1977-03-22	Process for preparation of prostaglandin derivatives and pharmceutical composition containing the compounds as effectual components
US4235997A (en)	1980-11-25	6-Alkoxy-ω-aryl-PGI1 compounds
JPS5452069A (en)	1979-04-24	Prostaglandin i2 analog compound and its preparation
JPS5430147A (en)	1979-03-06	Prostaglandin i, analogues and their preparation
US4255355A (en)	1981-03-10	2-Decarboxy-2-aminomethyl-6-keto-PGE1 compounds
JPS5476554A (en)	1979-06-19	Intermediate of prostaglandin analog and its production
IE812843L (en)	1982-06-05	Estra-4,9-dienes
JPS53127441A (en)	1978-11-07	Prostaglandin-like compounds and their preparation
JPS51122040A (en)	1976-10-25	A process for preparing prostaglandin analogues
US4289877A (en)	1981-09-15	2-Decarboxy-2-tetrazolyl-9-deoxy-5,9α-epoxy-4,5-cis-17,18-tetradehydro-PGF1 compounds