JPS5492986A - Cephalosporin derivative - Google Patents
Cephalosporin derivativeInfo
- Publication number
- JPS5492986A JPS5492986A JP16090477A JP16090477A JPS5492986A JP S5492986 A JPS5492986 A JP S5492986A JP 16090477 A JP16090477 A JP 16090477A JP 16090477 A JP16090477 A JP 16090477A JP S5492986 A JPS5492986 A JP S5492986A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- group
- gram
- cephalosporin derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Natural products P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000005604 azodicarboxylate group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000007942 carboxylates Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- -1 phosphine compound Chemical class 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A cephalosporin derivative of formula I: [R1 is amino group which may be acylated; R2 is carboxyl group which may be esterified; Y is group- CH(R3)-S-(R3 is H or alkyl group), formula II (R4 is H or OH),-C(R5)=CH-NH- (R5 is H or halogen), etc.] and its salt.
EXAMPLE: A compound of formula III.
USE: Diseases of man and animals, particularly preventives, remedies of infectious diseases by Gram-positive and Gram-negative bacteria.
PROCESS: A compound of formula IV: (R6' is acyl group; R2' is carboxylate) is reacted with a compound of formula V: (Y' is the same as Y) in the presence of a phosphine compound and an azodicarboxylate in an inert solvent, e.g. THF, at room temperature to give a compound of formula VI, which is one of the objective compound.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16090477A JPS5492986A (en) | 1977-12-28 | 1977-12-28 | Cephalosporin derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16090477A JPS5492986A (en) | 1977-12-28 | 1977-12-28 | Cephalosporin derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5492986A true JPS5492986A (en) | 1979-07-23 |
Family
ID=15724847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16090477A Pending JPS5492986A (en) | 1977-12-28 | 1977-12-28 | Cephalosporin derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5492986A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2536074A1 (en) * | 1982-11-17 | 1984-05-18 | Toyama Chemical Co Ltd | NEW CEPHALOSPORINS, PROCESSES FOR PREPARING THEM, ANTIBACTERIAL AGENTS CONTAINING SAME, INTERMEDIATES FOR THEIR PREPARATION, AND PROCESS FOR THE PREPARATION OF INTERMEDIATES |
| WO1986005184A1 (en) * | 1985-03-01 | 1986-09-12 | Takeda Chemical Industries, Ltd. | Antibacterial compound |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53119885A (en) * | 1977-03-29 | 1978-10-19 | Takeda Chem Ind Ltd | Cephalosporin derivatives |
-
1977
- 1977-12-28 JP JP16090477A patent/JPS5492986A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53119885A (en) * | 1977-03-29 | 1978-10-19 | Takeda Chem Ind Ltd | Cephalosporin derivatives |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2536074A1 (en) * | 1982-11-17 | 1984-05-18 | Toyama Chemical Co Ltd | NEW CEPHALOSPORINS, PROCESSES FOR PREPARING THEM, ANTIBACTERIAL AGENTS CONTAINING SAME, INTERMEDIATES FOR THEIR PREPARATION, AND PROCESS FOR THE PREPARATION OF INTERMEDIATES |
| WO1986005184A1 (en) * | 1985-03-01 | 1986-09-12 | Takeda Chemical Industries, Ltd. | Antibacterial compound |
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