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JPS5466651A - Preparation of o-(2,6-dichloroanilino)phenylacetic acid - Google Patents

Preparation of o-(2,6-dichloroanilino)phenylacetic acid

Info

Publication number
JPS5466651A
JPS5466651A JP13086377A JP13086377A JPS5466651A JP S5466651 A JPS5466651 A JP S5466651A JP 13086377 A JP13086377 A JP 13086377A JP 13086377 A JP13086377 A JP 13086377A JP S5466651 A JPS5466651 A JP S5466651A
Authority
JP
Japan
Prior art keywords
pref
moles
compound
base
dichloroanilino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13086377A
Other languages
Japanese (ja)
Inventor
Yasuyuki Ono
Fumio Nishimura
Kentaro Tamaoki
Kyoichi Fujii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP13086377A priority Critical patent/JPS5466651A/en
Publication of JPS5466651A publication Critical patent/JPS5466651A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound which is a non-steroid-type antiphlogistic analogesic agent, easily, by reducing O-(2,6-dichloroanilino)-α-hydroxyphenyl-acetic acid with iodine and phosphorus pref. in the presence of a base.
CONSTITUTION: The objective compound II is prepared by reducing 1 mole of a compound I (novel compound) with 1-10 moles (pref. 3-5 moles) of iodine and 1-5 moles (pref. 1-3 moles) of phosphorus in an inert solvent (carbon disulfide, benzene, etc.) pref. in the presence of a base such as pyridine, picoline, dimethylaniline, etc., at room terperature for 5 min. to 48 hours.
EFFECT: The reaction proceeds at a low temperature, and reaction yield is high. The presence of base suppresses the side reactions, and gives the objective compound in high purity.
COPYRIGHT: (C)1979,JPO&Japio
JP13086377A 1977-11-02 1977-11-02 Preparation of o-(2,6-dichloroanilino)phenylacetic acid Pending JPS5466651A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13086377A JPS5466651A (en) 1977-11-02 1977-11-02 Preparation of o-(2,6-dichloroanilino)phenylacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13086377A JPS5466651A (en) 1977-11-02 1977-11-02 Preparation of o-(2,6-dichloroanilino)phenylacetic acid

Publications (1)

Publication Number Publication Date
JPS5466651A true JPS5466651A (en) 1979-05-29

Family

ID=15044453

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13086377A Pending JPS5466651A (en) 1977-11-02 1977-11-02 Preparation of o-(2,6-dichloroanilino)phenylacetic acid

Country Status (1)

Country Link
JP (1) JPS5466651A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57144239A (en) * 1981-02-24 1982-09-06 Ciba Geigy Ag External pharmaceutical composition containing alkane carboxylate, novel carboxylate and manufacture

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57144239A (en) * 1981-02-24 1982-09-06 Ciba Geigy Ag External pharmaceutical composition containing alkane carboxylate, novel carboxylate and manufacture
JPH0521907B2 (en) * 1981-02-24 1993-03-25 Ciba Geigy

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