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JPS54148773A - Preparation of phthalide - Google Patents

Preparation of phthalide

Info

Publication number
JPS54148773A
JPS54148773A JP5686578A JP5686578A JPS54148773A JP S54148773 A JPS54148773 A JP S54148773A JP 5686578 A JP5686578 A JP 5686578A JP 5686578 A JP5686578 A JP 5686578A JP S54148773 A JPS54148773 A JP S54148773A
Authority
JP
Japan
Prior art keywords
alcohol
alkali
dihalomethyl
moles
benzene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5686578A
Other languages
Japanese (ja)
Other versions
JPS6139946B2 (en
Inventor
Kazuhisa Nakajima
Kazumasa Hirata
Akira Yamashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Nippon Synthetic Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Synthetic Chemical Industry Co Ltd filed Critical Nippon Synthetic Chemical Industry Co Ltd
Priority to JP5686578A priority Critical patent/JPS54148773A/en
Publication of JPS54148773A publication Critical patent/JPS54148773A/en
Publication of JPS6139946B2 publication Critical patent/JPS6139946B2/ja
Granted legal-status Critical Current

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Abstract

PURPOSE: To obtain the title compound usable for antidepressives and intermediates for medicines in high yield and purity, by reacting an inexpensive available 1,2- bis-(dihalomethyl)benzene with an alkali in a specific mixed solvent under relatively mild conditions.
CONSTITUTION: One mole of a 1,2-bis(dihalomethyl)benzene is reacted with 7W15 moles, preferably 8W10 moles, of an alkali, e.g. NaOH or KOH, in a mixed solvent of water and an alcohol at 50°CW the reflux temperature to give an alkali metal salt of 2-hydroxymethylbenzoic acid, which is treated with an acid to give the title compound. The mixing volume ratio of the water to alcohol is 1:0.5W2, preferably 1:0.6W1. Ethyl alcohol is preferably used as the alcohol.
COPYRIGHT: (C)1979,JPO&Japio
JP5686578A 1978-05-12 1978-05-12 Preparation of phthalide Granted JPS54148773A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5686578A JPS54148773A (en) 1978-05-12 1978-05-12 Preparation of phthalide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5686578A JPS54148773A (en) 1978-05-12 1978-05-12 Preparation of phthalide

Publications (2)

Publication Number Publication Date
JPS54148773A true JPS54148773A (en) 1979-11-21
JPS6139946B2 JPS6139946B2 (en) 1986-09-06

Family

ID=13039307

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5686578A Granted JPS54148773A (en) 1978-05-12 1978-05-12 Preparation of phthalide

Country Status (1)

Country Link
JP (1) JPS54148773A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105418577A (en) * 2015-11-26 2016-03-23 苏州黄河制药有限公司 Method for synthesizing doxepin hydrochloride from o-phthalaldehyde

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105418577A (en) * 2015-11-26 2016-03-23 苏州黄河制药有限公司 Method for synthesizing doxepin hydrochloride from o-phthalaldehyde

Also Published As

Publication number Publication date
JPS6139946B2 (en) 1986-09-06

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